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01-09-2014 | Brief Report

Genetic characterization of emerging coxsackievirus A12 associated with hand, foot and mouth disease in Qingdao, China

Authors: Xiaolin Liu, Naiying Mao, Weisen Yu, Qing Chai, Hui Wang, Weidong Wang, Lijuan Wang, Zhaoguo Wang, Wenbo Xu

Published in: Archives of Virology | Issue 9/2014

Abstract

To characterize the genetic properties of coxsackievirus A12 (CVA12) strains isolated from hand, foot and mouth disease (HFMD) patients in Qingdao during 2008-2011, the complete genome and VP1 coding region were sequenced and analyzed. Phylogenetic analysis showed that all strains from China clustered into three different branches, suggesting multiple lineages of CVA12 co-circulating in Asia. Sequence analysis indicated a monophyletic group only when the P1 region was examined, indicating possible recombination between CVA12 and other HEV-A serotypes. The emergence of CVA12 involved in an HFMD outbreak in China is a public-health issue.

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Title: Genetic characterization of emerging coxsackievirus A12 associated with hand, foot and mouth disease in Qingdao, China
Authors: Xiaolin Liu
Naiying Mao
Weisen Yu
Qing Chai
Hui Wang
Weidong Wang
Lijuan Wang
Zhaoguo Wang
Wenbo Xu
Publication date: 01-09-2014
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 9/2014
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-014-2067-6

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