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Journal of Assisted Reproduction and Genetics

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01-05-2015 | Genetics

Genetic association between FXIII and β-fibrinogen genes and women with recurrent spontaneous abortion: a meta- analysis

Authors: Jie Li, Hongbo Wu, Yang Chen, Huimei Wu, Hong Xu, Liuming Li

Published in: Journal of Assisted Reproduction and Genetics | Issue 5/2015

Abstract

Background

FXIII Val34Leu (rs5985) and β-fibrinogen -455G/A (rs1800790) genotypes have been reported to be associated with recurrent spontaneous abortion (RSA). However, this topic is controversial. This study aimed to explore whether FXIII Val34Leu or β-fibrinogen -455G/A gene polymorphisms are related to RSA.

Methods

In this analysis, PubMed, HuGENet and Chinese National Knowledge Infrastructure (CNKI) databases were reviewed. Four models including the dominant model (Val/Val+Val/Leu vs. Leu/Leu), recessive model (Val/Val vs Val/Leu+Leu/Leu), co-dominant model (Val/Val vs. Val/Leu, Val/Val vs. Leu/Leu) and per-allele analysis (Val vs. Leu) were applied. The odds ratio (OR) with 95 % confidence interval (CI) was used to assess the association between RSA and FXIII Val34Leu and β-fibrinogen -455G/A polymorphisms.

Results

Nine studies with 10 sets of data were included according to the inclusion criterion. A positive association was detected in the pooled results for the dominant model (Val/Val+Val/Leu vs. Leu/Leu; OR = 0.417, 95 % CI: 0.180–0.965, I ² = 45.60 %) and co-dominant model (Val/Val vs. Val/Leu; OR = 0.638, 95 % CI: 0.452–0.899, I ² = 36.40 %) for FXIII Val34Leu polymorphisms. However, no statistically significant association between β-fibrinogen -455G/A polymorphisms and RSA was detected in the four different models, including the Asian and Caucasian subgroup analyses.

Conclusions

Our meta-analysis demonstrates that the FXIII Val34Leu polymorphism has a close association with RSA and women who carry the Val allele for the FXIII Val34Leu polymorphism could have a protective effect against RSA. However, no association is detected between β-fibrinogen -455G/A polymorphisms and the risk of RSA. Future well-designed studies are needed to confirm these results.

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Title: Genetic association between FXIII and β-fibrinogen genes and women with recurrent spontaneous abortion: a meta- analysis
Authors: Jie Li
Hongbo Wu
Yang Chen
Huimei Wu
Hong Xu
Liuming Li
Publication date: 01-05-2015
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 5/2015
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-015-0471-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Genetic association between FXIII and β-fibrinogen genes and women with recurrent spontaneous abortion: a meta- analysis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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