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Open Access 01-06-2014 | Oral presentation

Genetic and phenotypic determinants of flavonoid absorption and metabolism: the COB study

Authors: Sumanto Haldar, Noemí T Hernandez, Luisa Ostertag, Peter Curtis, Aedín Cassidy, Anne Marie Minihane

Published in: Archives of Public Health | Special Issue 1/2014

Excerpt

Flavonoids are present in numerous plant foods, including fruits, vegetables, teas, red wine, cocoa, herbs, and spices. Epidemiological data, along with evidence from cell, animal, and limited human intervention trial studies suggest that flavonoids can improve cardiovascular health and reduce the risk of other ageing-related diseases [1‐6]. However, the absorption and metabolism of flavonoids, their metabolite profile, and their associated health benefits are highly heterogeneous [7], with the aetiological basis of this variability currently unknown. Our recent stable isotope study, which fed an oral bolus dose of 500 mg ¹³C-labeled cyanidin-3-glucoside to healthy men showed a wide inter-individual variability in anthocyanin metabolism [7]. …

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Jennings A, Welch AA, Fairweather-Tait SJ, Kay C, Minihane AM, Chowienczyk P, Jiang B, Cecelja M, Spector T, Macgregor A, et al: Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women. Am J Clin Nutr. 2012, 96: 781-788.CrossRefPubMed

Peterson JJ, Dwyer JT, Jacques PF, McCullough ML: Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations. Nutr Rev. 2012, 70: 491-508.PubMedCentralCrossRefPubMed

Hooper L, Kroon PA, Rimm EB, Cohn JS, Harvey I, Le Cornu KA, Ryder JJ, Hall WL, Cassidy A: Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2008, 88: 38-50.PubMed

Czank C, Cassidy A, Zhang Q, Morrison DJ, Preston T, Kroon PA, Botting NP, Kay CD: Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13)C-tracer study. Am J Clin Nutr. 2013, 97: 995-1003.CrossRefPubMed

Title: Genetic and phenotypic determinants of flavonoid absorption and metabolism: the COB study
Authors: Sumanto Haldar
Noemí T Hernandez
Luisa Ostertag
Peter Curtis
Aedín Cassidy
Anne Marie Minihane
Publication date: 01-06-2014
Publisher: BioMed Central
Published in: Archives of Public Health / Issue Special Issue 1/2014
Electronic ISSN: 2049-3258
DOI: https://doi.org/10.1186/2049-3258-72-S1-O3

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