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Open Access 01-12-2005 | Research

Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV

Authors: Fanny WF Shum, Shanelle W Ko, Yong-Seok Lee, Bong-Kiun Kaang, Min Zhuo

Published in: Molecular Pain | Issue 1/2005

Abstract

Calcium-calmodulin-dependent protein kinase IV (CaMKIV) phosphorylates the major transcription factor cyclic AMP-response element binding protein (CREB), which plays a role in emotional behavior. Here, CaMKIV knockout mice (CaMKIV^-/-) were tested in a battery of stress and anxiety-related behavioral tests, to determine if CaMKIV plays a role in emotional behavior. CaMKIV^-/-exhibited a decrease in anxiety-like behavior in both the elevated plus maze and dark-light emergence tests when compared to wild-type mice. Both the acoustic startle response and prepulse inhibition of startle were decreased with the deletion of CaMKIV. In addition, CaMKIV^-/- mice displayed a lack of stress-induced analgesia following restraint or cold swim stress. Our results demonstrate a key role for CaMKIV in anxiety and stress-related behavior.

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Title: Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV
Authors: Fanny WF Shum
Shanelle W Ko
Yong-Seok Lee
Bong-Kiun Kaang
Min Zhuo
Publication date: 01-12-2005
Publisher: BioMed Central
Published in: Molecular Pain / Issue 1/2005
Electronic ISSN: 1744-8069
DOI: https://doi.org/10.1186/1744-8069-1-22

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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