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01-07-2003 | Commentary

Genes and pathways driving glioblastomas in humans and murine disease models

Author: Karl Frei

Published in: Neurosurgical Review | Issue 3/2003

Excerpt

This scholarly review describes characteristic genetic alterations that underlie the initiation and progression of glioblastomas in humans and rodent models. These alterations include the inactivation of tumor suppressor genes such as TP53, CDKN2A/p16, RB, and PTEN and activation of oncogenes including the epidermal growth factor receptor (EGFR), CDK4, CDK6, Ras, and Akt. …

Title: Genes and pathways driving glioblastomas in humans and murine disease models
Author: Karl Frei
Publication date: 01-07-2003
Publisher: Springer Berlin Heidelberg
Published in: Neurosurgical Review / Issue 3/2003
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI: https://doi.org/10.1007/s10143-003-0269-6

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Genes and pathways driving glioblastomas in humans and murine disease models

Excerpt

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