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19-04-2024 | Generalised Anxiety Disorder | Original Paper

Healthcare Utilization and Its Correlates in Comorbid Type 2 Diabetes Mellitus and Generalized Anxiety Disorder

Authors: Chun-Jen Huang, Ching-Hua Lin, Tai-Ling Liu, Pai-Cheng Lin, Chin-Chen Chu, Jhi‑Joung Wang, Chun-Wang Wei, Shih-Feng Weng

Published in: Psychiatric Quarterly

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Abstract

This study investigated the healthcare utilization and medical expenditure of type 2 diabetes mellitus (T2DM) patients with generalized anxiety disorder (GAD) and identified the associated factors. The healthcare utilization and expenditure of T2DM patients with (case group) and without (control group) GAD between 2002 and 2013 were examined using the population-based Taiwan National Health Insurance Research Database. Healthcare utilization included outpatient visits and hospitalization; health expenditure included outpatient, inpatient, and total medical expenditure. Moreover, nonpsychiatric healthcare utilization and medical expenditure were distinguished from total healthcare utilization and medical expenditure. The average healthcare utilization, including outpatient visits and hospitalization, was significantly higher for the case group than for the control group (total and nonpsychiatric). The results regarding differences in average outpatient expenditure (total and nonpsychiatric), inpatient expenditure (total and nonpsychiatric), and total expenditure (total and nonpsychiatric) between the case and control groups are inconsistent. Sex, age, income, comorbidities/complications, and the diabetes mellitus complication severity index were significantly associated with outpatient visits, medical expenditure, and hospitalization in the case group (total and nonpsychiatric). Greater knowledge of factors affecting healthcare utilization and expenditure in comorbid individuals may help healthcare providers intervene to improve patient management and possibly reduce the healthcare burden in the future.
Literature
1.
go back to reference Lin WH, Hsu CH, Chen HF, Liu CC, Li CY. Mortality of patients with type 2 diabetes in Taiwan: a 10-year nationwide follow-up study. Diabetes Res Clin Pract. 2015;107:178–86.PubMedCrossRef Lin WH, Hsu CH, Chen HF, Liu CC, Li CY. Mortality of patients with type 2 diabetes in Taiwan: a 10-year nationwide follow-up study. Diabetes Res Clin Pract. 2015;107:178–86.PubMedCrossRef
2.
go back to reference Holman N, Forouhi N, Goyder E, Wild S. The Association of Public Health Observatories (APHO) diabetes prevalence model: estimates of total diabetes prevalence for England, 2010–2030. Diabet Med. 2011;28:575–82.PubMedCrossRef Holman N, Forouhi N, Goyder E, Wild S. The Association of Public Health Observatories (APHO) diabetes prevalence model: estimates of total diabetes prevalence for England, 2010–2030. Diabet Med. 2011;28:575–82.PubMedCrossRef
3.
go back to reference Akena D, Kadama P, Ashaba S, Akello C, Kwesiga B, Rejani L, et al. The association between depression, quality of life, and the health care expenditure of patients with diabetes mellitus in Uganda. J Affect Disord. 2015;174:7–12.PubMedCrossRef Akena D, Kadama P, Ashaba S, Akello C, Kwesiga B, Rejani L, et al. The association between depression, quality of life, and the health care expenditure of patients with diabetes mellitus in Uganda. J Affect Disord. 2015;174:7–12.PubMedCrossRef
4.
go back to reference Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2197–223.PubMedCrossRef Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2197–223.PubMedCrossRef
5.
go back to reference Molosankwe I, Patel A, Gagliardino JJ, Knapp M, McDaid D. Economic aspects of the association between diabetes and depression: a systematic review. J Affect Disord. 2012;142:S42–55.PubMedCrossRef Molosankwe I, Patel A, Gagliardino JJ, Knapp M, McDaid D. Economic aspects of the association between diabetes and depression: a systematic review. J Affect Disord. 2012;142:S42–55.PubMedCrossRef
6.
go back to reference Harris MI. Diabetes in America: epidemiology and scope of the problem. Diabetes Care. 1998;21(Suppl 3):C11–4.PubMedCrossRef Harris MI. Diabetes in America: epidemiology and scope of the problem. Diabetes Care. 1998;21(Suppl 3):C11–4.PubMedCrossRef
7.
go back to reference Association AD. Economic consequences of diabetes mellitus in the U.S. in 1997. Diabetes Care. 1998;21:296–309.CrossRef Association AD. Economic consequences of diabetes mellitus in the U.S. in 1997. Diabetes Care. 1998;21:296–309.CrossRef
8.
go back to reference Barrera TL, Mott JM, Hundt NE, Mignogna J, Yu HJ, Stanley MA, et al. Diagnostic specificity and mental health service utilization among veterans with newly diagnosed anxiety disorders. Gen Hosp Psychiatry. 2014;36:192–8.PubMedCrossRef Barrera TL, Mott JM, Hundt NE, Mignogna J, Yu HJ, Stanley MA, et al. Diagnostic specificity and mental health service utilization among veterans with newly diagnosed anxiety disorders. Gen Hosp Psychiatry. 2014;36:192–8.PubMedCrossRef
9.
go back to reference Maier W, Gänsicke M, Freyberger H, Linz M, Heun R, Lecrubier Y. Generalized anxiety disorder (ICD-10) in primary care from a cross-cultural perspective: a valid diagnostic entity? Acta Psychiatr Scand. 2000;101:29–36.PubMedCrossRef Maier W, Gänsicke M, Freyberger H, Linz M, Heun R, Lecrubier Y. Generalized anxiety disorder (ICD-10) in primary care from a cross-cultural perspective: a valid diagnostic entity? Acta Psychiatr Scand. 2000;101:29–36.PubMedCrossRef
10.
go back to reference Kujanpaa T, Ylisaukko-Oja T, Jokelainen J, Linna M, Timonen M. Comparative cost analysis of generalized anxiety disorder and major depressive disorder patients in secondary care from a national hospital registry in Finland. Nord J Psychiatry. 2014;68:306–10.PubMedCrossRef Kujanpaa T, Ylisaukko-Oja T, Jokelainen J, Linna M, Timonen M. Comparative cost analysis of generalized anxiety disorder and major depressive disorder patients in secondary care from a national hospital registry in Finland. Nord J Psychiatry. 2014;68:306–10.PubMedCrossRef
11.
go back to reference Hoffman DL, Dukes EM, Wittchen HU. Human and economic burden of generalized anxiety disorder. Depress Anxiety. 2008;25:72–90.PubMedCrossRef Hoffman DL, Dukes EM, Wittchen HU. Human and economic burden of generalized anxiety disorder. Depress Anxiety. 2008;25:72–90.PubMedCrossRef
12.
go back to reference Chien IC, Wu EL, Lin CH, Chou YJ, Chou P. Prevalence of diabetes in patients with major depressive disorder: a population-based study. Compr Psychiatry. 2012;53:569–75.PubMedCrossRef Chien IC, Wu EL, Lin CH, Chou YJ, Chou P. Prevalence of diabetes in patients with major depressive disorder: a population-based study. Compr Psychiatry. 2012;53:569–75.PubMedCrossRef
13.
go back to reference Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990–2020: global burden of disease study. Lancet. 1997;349:1498–504.PubMedCrossRef Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990–2020: global burden of disease study. Lancet. 1997;349:1498–504.PubMedCrossRef
14.
go back to reference Clarke PM, Glasziou P, Patel A, Chalmers J, Woodward M, Harrap SB, et al. Event rates, hospital utilization, and costs associated with major complications of diabetes: a multicountry comparative analysis. PLoS Med. 2010;7:1000236.PubMedPubMedCentralCrossRef Clarke PM, Glasziou P, Patel A, Chalmers J, Woodward M, Harrap SB, et al. Event rates, hospital utilization, and costs associated with major complications of diabetes: a multicountry comparative analysis. PLoS Med. 2010;7:1000236.PubMedPubMedCentralCrossRef
15.
go back to reference Gulliford MC, Latinovic R, Charlton J. Diabetes diagnosis, resource utilization, and health outcomes. Am J Manag Care. 2008;14:32–8.PubMed Gulliford MC, Latinovic R, Charlton J. Diabetes diagnosis, resource utilization, and health outcomes. Am J Manag Care. 2008;14:32–8.PubMed
16.
go back to reference Nichols GA, Brown JB. The impact of cardiovascular disease on medical care costs in subjects with and without type 2 diabetes. Diabetes Care. 2002;25:482–6.PubMedCrossRef Nichols GA, Brown JB. The impact of cardiovascular disease on medical care costs in subjects with and without type 2 diabetes. Diabetes Care. 2002;25:482–6.PubMedCrossRef
17.
go back to reference Williams R, Van Gaal L, Lucioni C. Assessing the impact of complications on the costs of Type II diabetes. Diabetologia. 2002;45:S13–7.PubMedCrossRef Williams R, Van Gaal L, Lucioni C. Assessing the impact of complications on the costs of Type II diabetes. Diabetologia. 2002;45:S13–7.PubMedCrossRef
18.
go back to reference Huang CJ, Lin CH, Lee MH, Chang KP, Chiu HC. Prevalence and incidence of diagnosed depression disorders in patients with diabetes: a national population-based cohort study. Gen Hosp Psychiatry. 2012;34:242–8.PubMedCrossRef Huang CJ, Lin CH, Lee MH, Chang KP, Chiu HC. Prevalence and incidence of diagnosed depression disorders in patients with diabetes: a national population-based cohort study. Gen Hosp Psychiatry. 2012;34:242–8.PubMedCrossRef
19.
go back to reference Huang CJ, Chiu HC, Lee MH, Wang SY. Prevalence and incidence of anxiety disorders in diabetic patients: a national population-based cohort study. Gen Hosp Psychiatry. 2011;33:8–15.PubMedCrossRef Huang CJ, Chiu HC, Lee MH, Wang SY. Prevalence and incidence of anxiety disorders in diabetic patients: a national population-based cohort study. Gen Hosp Psychiatry. 2011;33:8–15.PubMedCrossRef
20.
go back to reference Hsu JH, Chien IC, Lin CH, Chou YJ, Chou P. Incidence of Diabetes in Patients With Schizophrenia: a Population-based Study. Can J Psychiatry. 2011;56:19–26.PubMedCrossRef Hsu JH, Chien IC, Lin CH, Chou YJ, Chou P. Incidence of Diabetes in Patients With Schizophrenia: a Population-based Study. Can J Psychiatry. 2011;56:19–26.PubMedCrossRef
21.
go back to reference Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care. 2001;24:1069–78.PubMedCrossRef Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care. 2001;24:1069–78.PubMedCrossRef
22.
go back to reference Vamos EP, Mucsi I, Keszei A, Kopp MS, Novak M. Comorbid depression is associated with increased healthcare utilization and lost productivity in persons with diabetes: a large nationally representative Hungarian population survey. Psychosom Med. 2009;71:501–7.PubMedCrossRef Vamos EP, Mucsi I, Keszei A, Kopp MS, Novak M. Comorbid depression is associated with increased healthcare utilization and lost productivity in persons with diabetes: a large nationally representative Hungarian population survey. Psychosom Med. 2009;71:501–7.PubMedCrossRef
23.
go back to reference Nichols L, Barton PL, Glazner J, McCollum M. Diabetes, minor depression and health care utilization and expenditures: a retrospective database study. Cost Eff Resour Alloc. 2007;5:4.PubMedPubMedCentralCrossRef Nichols L, Barton PL, Glazner J, McCollum M. Diabetes, minor depression and health care utilization and expenditures: a retrospective database study. Cost Eff Resour Alloc. 2007;5:4.PubMedPubMedCentralCrossRef
24.
go back to reference Simon GE, Katon WJ, Lin EH, Ludman E, VonKorff M, Ciechanowski P, et al. Diabetes complications and depression as predictors of health service costs. Gen Hosp Psychiatry. 2005;27:344–51.PubMedCrossRef Simon GE, Katon WJ, Lin EH, Ludman E, VonKorff M, Ciechanowski P, et al. Diabetes complications and depression as predictors of health service costs. Gen Hosp Psychiatry. 2005;27:344–51.PubMedCrossRef
25.
go back to reference Finkelstein EA, Bray JW, Chen H, Larson MJ, Miller K, Tompkins C, et al. Prevalence and costs of major depression among elderly claimants with diabetes. Diabetes Care. 2003;26:415–20.PubMedCrossRef Finkelstein EA, Bray JW, Chen H, Larson MJ, Miller K, Tompkins C, et al. Prevalence and costs of major depression among elderly claimants with diabetes. Diabetes Care. 2003;26:415–20.PubMedCrossRef
26.
go back to reference Egede LE, Zheng D, Simpson K. Comorbid depression is associated with increased health care use and expenditures in individuals with diabetes. Diabetes Care. 2002;25:464–70.PubMedCrossRef Egede LE, Zheng D, Simpson K. Comorbid depression is associated with increased health care use and expenditures in individuals with diabetes. Diabetes Care. 2002;25:464–70.PubMedCrossRef
27.
go back to reference Ciechanowski PS, Katon WJ, Russo JE. Depression and diabetes: impact of depressive symptoms on adherence, function, and costs. Arch Intern Med. 2000;160:3278–85.PubMedCrossRef Ciechanowski PS, Katon WJ, Russo JE. Depression and diabetes: impact of depressive symptoms on adherence, function, and costs. Arch Intern Med. 2000;160:3278–85.PubMedCrossRef
28.
go back to reference Huang CJ, Chiu HC, Hsieh HM, Yen JY, Lee MH, Chang KP, et al. Health care utilization and expenditures of persons with diabetes comorbid with anxiety disorder: a national population-based cohort study. Gen Hosp Psychiatry. 2015;37:299–304.PubMedCrossRef Huang CJ, Chiu HC, Hsieh HM, Yen JY, Lee MH, Chang KP, et al. Health care utilization and expenditures of persons with diabetes comorbid with anxiety disorder: a national population-based cohort study. Gen Hosp Psychiatry. 2015;37:299–304.PubMedCrossRef
29.
go back to reference Huang C-J, Wang S-Y, Lee M-H, Chiu H-C. Prevalence and incidence of mental illness in diabetes: a national population-based cohort study. Diabetes Res Clin Pract. 2011;93:106–14.PubMedCrossRef Huang C-J, Wang S-Y, Lee M-H, Chiu H-C. Prevalence and incidence of mental illness in diabetes: a national population-based cohort study. Diabetes Res Clin Pract. 2011;93:106–14.PubMedCrossRef
30.
go back to reference Young BA, Lin E, Von Korff M, Simon G, Ciechanowski P, Ludman EJ, et al. Diabetes complications severity index and risk of mortality, hospitalization, and healthcare utilization. Am J Manag Care. 2008;14:15–23.PubMedPubMedCentral Young BA, Lin E, Von Korff M, Simon G, Ciechanowski P, Ludman EJ, et al. Diabetes complications severity index and risk of mortality, hospitalization, and healthcare utilization. Am J Manag Care. 2008;14:15–23.PubMedPubMedCentral
31.
go back to reference Chiu HC, Shi HY, Mau LW, Wang GJ. The effects of a prospective case payment system on hospital charges for total hip arthroplasty in Taiwan. J Arthroplasty. 2007;22:65–71.PubMedCrossRef Chiu HC, Shi HY, Mau LW, Wang GJ. The effects of a prospective case payment system on hospital charges for total hip arthroplasty in Taiwan. J Arthroplasty. 2007;22:65–71.PubMedCrossRef
32.
go back to reference Sullivan G, Han X, Moore S, Kotrla K. Disparities in hospitalization for diabetes among persons with and without co-occurring mental disorders. Psychiatr Serv. 2006;57:1126–31.PubMedCrossRef Sullivan G, Han X, Moore S, Kotrla K. Disparities in hospitalization for diabetes among persons with and without co-occurring mental disorders. Psychiatr Serv. 2006;57:1126–31.PubMedCrossRef
33.
go back to reference Garrison MM, Katon WJ, Richardson LP. The impact of psychiatric comorbidities on readmissions for diabetes in youth. Diabetes Care. 2005;28:2150–4.PubMedCrossRef Garrison MM, Katon WJ, Richardson LP. The impact of psychiatric comorbidities on readmissions for diabetes in youth. Diabetes Care. 2005;28:2150–4.PubMedCrossRef
34.
go back to reference Hutter N, Schnurr A, Baumeister H. Healthcare costs in patients with diabetes mellitus and comorbid mental disorders—a systematic review. Diabetologia. 2010;53:2470–9.PubMedCrossRef Hutter N, Schnurr A, Baumeister H. Healthcare costs in patients with diabetes mellitus and comorbid mental disorders—a systematic review. Diabetologia. 2010;53:2470–9.PubMedCrossRef
35.
go back to reference Black G, Roberts RM, Li-Leng T. Depression in rural adolescents: relationships with gender and availability of mental health services. Rural Remote Health. 2012;12:2092.PubMed Black G, Roberts RM, Li-Leng T. Depression in rural adolescents: relationships with gender and availability of mental health services. Rural Remote Health. 2012;12:2092.PubMed
36.
go back to reference Wang W, Fu C, Zhuo H, Luo J, Xu B. Factors affecting costs and utilization of type 2 diabetes healthcare: a cross-sectional survey among 15 hospitals in urban China. BMC Health Serv Res. 2010;10:244.PubMedPubMedCentralCrossRef Wang W, Fu C, Zhuo H, Luo J, Xu B. Factors affecting costs and utilization of type 2 diabetes healthcare: a cross-sectional survey among 15 hospitals in urban China. BMC Health Serv Res. 2010;10:244.PubMedPubMedCentralCrossRef
37.
go back to reference Chaikledkaew U, Pongchareonsuk P, Chaiyakunapruk N, Ongphiphadhanakul B. Factors affecting health-care costs and hospitalizations among diabetic patients in Thai public hospitals. Value Health. 2008;11:S69–74.PubMedCrossRef Chaikledkaew U, Pongchareonsuk P, Chaiyakunapruk N, Ongphiphadhanakul B. Factors affecting health-care costs and hospitalizations among diabetic patients in Thai public hospitals. Value Health. 2008;11:S69–74.PubMedCrossRef
38.
go back to reference Rost K, Zhang M, Fortney J, Smith J, Smith GR Jr. Rural-urban differences in depression treatment and suicidality. Med Care. 1998;36:1098–107.PubMedCrossRef Rost K, Zhang M, Fortney J, Smith J, Smith GR Jr. Rural-urban differences in depression treatment and suicidality. Med Care. 1998;36:1098–107.PubMedCrossRef
39.
go back to reference Su C-H, Chiu H-C, Hsieh H-M, Yen J-Y, Lee M-H, Li C-Y, et al. Healthcare Utilization and Expenditures for Persons with Diabetes Comorbid with Mental Illnesses. Psychiatr Q. 2016;87:545–57.PubMedCrossRef Su C-H, Chiu H-C, Hsieh H-M, Yen J-Y, Lee M-H, Li C-Y, et al. Healthcare Utilization and Expenditures for Persons with Diabetes Comorbid with Mental Illnesses. Psychiatr Q. 2016;87:545–57.PubMedCrossRef
40.
go back to reference Blazer DG, Kessler RC, McGonagle KA, Swartz MS. The prevalence and distribution of major depression in a national community sample: the National Comorbidity Survey. Am J Psychiatry. 1994;151(7):979–86. Blazer DG, Kessler RC, McGonagle KA, Swartz MS. The prevalence and distribution of major depression in a national community sample: the National Comorbidity Survey. Am J Psychiatry. 1994;151(7):979–86.
41.
go back to reference Jackson-Triche ME, Sullivan JG, Wells KB, Rogers W, Camp P, Mazel R. Depression and health-related quality of life in ethnic minorities seeking care in general medical settings. J Affect Disord. 2000;58:89–97.PubMedCrossRef Jackson-Triche ME, Sullivan JG, Wells KB, Rogers W, Camp P, Mazel R. Depression and health-related quality of life in ethnic minorities seeking care in general medical settings. J Affect Disord. 2000;58:89–97.PubMedCrossRef
42.
go back to reference Amos AF, McCarty DJ, Zimmet P. The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabet Med. 1997;14(Suppl 5):S1-85.PubMed Amos AF, McCarty DJ, Zimmet P. The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabet Med. 1997;14(Suppl 5):S1-85.PubMed
43.
go back to reference Gu D, Reynolds K, Duan X, Xin X, Chen J, Wu X, et al. Prevalence of diabetes and impaired fasting glucose in the Chinese adult population: International Collaborative Study of Cardiovascular Disease in Asia (InterASIA). Diabetologia. 2003;46:1190–8.PubMedCrossRef Gu D, Reynolds K, Duan X, Xin X, Chen J, Wu X, et al. Prevalence of diabetes and impaired fasting glucose in the Chinese adult population: International Collaborative Study of Cardiovascular Disease in Asia (InterASIA). Diabetologia. 2003;46:1190–8.PubMedCrossRef
44.
go back to reference Lin CC, Lai MS, Syu CY, Chang SC, Tseng FY. Accuracy of diabetes diagnosis in health insurance claims data in Taiwan. J Formos Med Assoc. 2005;104:157–63.PubMed Lin CC, Lai MS, Syu CY, Chang SC, Tseng FY. Accuracy of diabetes diagnosis in health insurance claims data in Taiwan. J Formos Med Assoc. 2005;104:157–63.PubMed
45.
go back to reference Liptzin B, Regier DA, Goldberg ID. Utilization of health and mental health services in a large insured population. Am J Psychiatry. 1980;137:553–8.PubMedCrossRef Liptzin B, Regier DA, Goldberg ID. Utilization of health and mental health services in a large insured population. Am J Psychiatry. 1980;137:553–8.PubMedCrossRef
Metadata
Title
Healthcare Utilization and Its Correlates in Comorbid Type 2 Diabetes Mellitus and Generalized Anxiety Disorder
Authors
Chun-Jen Huang
Ching-Hua Lin
Tai-Ling Liu
Pai-Cheng Lin
Chin-Chen Chu
Jhi‑Joung Wang
Chun-Wang Wei
Shih-Feng Weng
Publication date
19-04-2024
Publisher
Springer US
Published in
Psychiatric Quarterly
Print ISSN: 0033-2720
Electronic ISSN: 1573-6709
DOI
https://doi.org/10.1007/s11126-024-10072-z