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01-09-2011 | Rapid Short Communication

Gene expression profiling of mouse growth plate cartilage by laser microdissection and microarray analysis

Authors: Honoka Isshiki, Kazuki Sato, Keisuke Horiuchi, Shuichi Tsutsumi, Makoto Kano, Hiroyasu Ikegami, Hitoshi Abe, Akihiro Umezawa, Hiroyuki Aburatani, Yoshiaki Toyama

Published in: Journal of Orthopaedic Science | Issue 5/2011

Excerpt

Longitudinal bone growth results from a complex sequence of events involving differentiation of resting chondroblasts into proliferative, pre-hypertrophic, and hypertrophic chondrocytes. The growth plate (epiphyseal plate), which is primarily responsible for longitudinal growth, can be divided into four distinct zones: the resting zone (RZ), proliferating zone (PZ), maturing zone (MZ), and hypertrophic zone (HZ), on the basis of the morphology of the developing chondroblasts and the structure of the cartilage matrix. In the past two decades substantial progress has been made in understanding the mechanisms underlying chondroblast differentiation and skeletal development [1‐3]. However, comprehensive analysis of gene expression patterns in the growth plate has been technically challenging. …

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Title: Gene expression profiling of mouse growth plate cartilage by laser microdissection and microarray analysis
Authors: Honoka Isshiki
Kazuki Sato
Keisuke Horiuchi
Shuichi Tsutsumi
Makoto Kano
Hiroyasu Ikegami
Hitoshi Abe
Akihiro Umezawa
Hiroyuki Aburatani
Yoshiaki Toyama
Publication date: 01-09-2011
Publisher: Springer Japan
Published in: Journal of Orthopaedic Science / Issue 5/2011
Print ISSN: 0949-2658
Electronic ISSN: 1436-2023
DOI: https://doi.org/10.1007/s00776-011-0119-2

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Gene expression profiling of mouse growth plate cartilage by laser microdissection and microarray analysis

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