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European Journal of Pediatrics
Published in: European Journal of Pediatrics 10/2012

01-10-2012 | Short Communication

Gender-specific reference intervals for cord blood leptin in Crete, Greece

Authors: Polyxeni Karakosta, Vaggelis Georgiou, Eleni Fthenou, Andrew Margioris, Elias Castanas, Manolis Kogevinas, Marilena Kampa, Leda Chatzi

Published in: European Journal of Pediatrics | Issue 10/2012

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Abstract

Cord leptin is a biomarker of fetal growth and adiposity with a role in predicting weight gain during the first months of life and childhood obesity. Our objective was to calculate gender-specific reference intervals for cord blood leptin in healthy neonates in Crete, Greece. We used data from the prospective mother–child cohort (“Rhea” study) in Crete, Greece. The analysis included 398 neonates chosen with strict inclusion criteria based on maternal and fetal characteristics. Cord leptin reference intervals for male neonates were 1.4–18.2 ng/mL and for females 2.0–25.8 ng/mL. Females had higher leptin levels (median 7.4; IQR 4.7–10.9) compared to males (median 4.9; IQR 3.2–7.6) (p < 0.001). Conclusion Gender-specific reference ranges are essential in clinical practice for correct interpretation of leptin values in cord blood and early detection of childhood obesity.
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Metadata
Title
Gender-specific reference intervals for cord blood leptin in Crete, Greece
Authors
Polyxeni Karakosta
Vaggelis Georgiou
Eleni Fthenou
Andrew Margioris
Elias Castanas
Manolis Kogevinas
Marilena Kampa
Leda Chatzi
Publication date
01-10-2012
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 10/2012
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-012-1804-7

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