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Langenbeck's Archives of Surgery

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01-10-2015 | Original Article

Gender-specific differences in therapy and laboratory parameters and validation of mortality predictors in severely injured patients—results of a German level 1 trauma center

Authors: Carsten Schoeneberg, Daniel Schmitz, Sandra Schoeneberg, Björn Hussmann, Sven Lendemans

Published in: Langenbeck's Archives of Surgery | Issue 7/2015

Abstract

Purpose

Gender-specific differences in trauma patients have been reported in several studies. There is a lack of knowledge about differences in therapy and laboratory parameters. The objective of this study is to analyze differences between genders, confirming the therapy and laboratory parameters. Additionally, predictors for mortality were validated.

Methods

Patients on primary admission to the hospital between 2002 and 2012 with an Injury Severity Score (ISS) ≥ 16 were included. 1073 patients met the inclusion criteria. Comparisons and matched-pair analyses between deceased and survived females, males, and between deceased females and males were conducted.

Results

The analyzed laboratory parameters differed between genders, especially the base excess, lactate, and coagulation parameters. In particular, females presented values that were normal or only slightly pathological. The prothrombin ratio was 75.3 % in female and 63.2 % in male (p = 0.027) and lactate 2.5 mmol/l in female and 3.8 mmol/l in male (p = 0.049). No differences between genders could be found in the initial treatment of severely injured patients. Only the infused volume differed between genders with 1178.2 ml in male and 793.6 ml in female (p = 0.02). The known predictors for mortality, lactate, and prothrombin ratio could not be validated in female trauma patients.

Conclusions

No gender differences, except the infused volume, in the treatment of severely injured patients could be found. Differences in laboratory tests, especially base excess, lactate, and coagulation parameters were found. As these parameters are also used as predictors of mortality in trauma patients, gender-specific cut-offs of these laboratory tests might be necessary to avoid underestimating injured women.

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Title: Gender-specific differences in therapy and laboratory parameters and validation of mortality predictors in severely injured patients—results of a German level 1 trauma center
Authors: Carsten Schoeneberg
Daniel Schmitz
Sandra Schoeneberg
Björn Hussmann
Sven Lendemans
Publication date: 01-10-2015
Publisher: Springer Berlin Heidelberg
Published in: Langenbeck's Archives of Surgery / Issue 7/2015
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-015-1327-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Gender-specific differences in therapy and laboratory parameters and validation of mortality predictors in severely injured patients—results of a German level 1 trauma center

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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