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Open Access 01-12-2019 | Research

Gender and survival of critically ill patients: results from the FROG-ICU study

Authors: Alexa Hollinger, Etienne Gayat, Elodie Féliot, Catherine Paugam-Burtz, Marie-Céline Fournier, Jacques Duranteau, Jean-Yves Lefrant, Marc Leone, Samir Jaber, Alexandre Mebazaa, Mattia Arrigo, On behalf of the FROG ICU study investigators

Published in: Annals of Intensive Care | Issue 1/2019

Abstract

Purpose

Few studies analyzed gender-related outcome differences of critically ill patients and found inconsistent results. This study aimed to test the independent association of gender and long-term survival of ICU patients.

Materials and methods

FROG-ICU was a prospective, observational, multi-center cohort designed to investigate the long-term mortality of critically ill adult patients. The primary endpoint of this study was 1-year mortality after ICU admission of women compared to men.

Results

The study included 2087 patients, 726 women and 1361 men. Women and men had similar baseline characteristics, clinical presentation, and disease severity. No significant difference in 1-year mortality was found between women and men (34.9% vs. 37.9%, P = 0.18). After multivariable adjustment, no difference in the hazard of death was observed [HR 0.99 (95% CI 0.77–1.28)]. Similar 1-year survival between women and men was found in a propensity score-matched patient cohort of 506 patients [HR 0.79 (95% CI 0.54–1.14)].

Conclusion

Women constituted one-third of the population of critically ill patients and were unexpectedly similar to men regarding demographic characteristics, clinical presentation, and disease severity and had similar risk of death at 1 year after ICU admission.

Trial registration ClinicalTrials.gov NCT01367093; registered on June 6, 2011.

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Title: Gender and survival of critically ill patients: results from the FROG-ICU study
Authors: Alexa Hollinger
Etienne Gayat
Elodie Féliot
Catherine Paugam-Burtz
Marie-Céline Fournier
Jacques Duranteau
Jean-Yves Lefrant
Marc Leone
Samir Jaber
Alexandre Mebazaa
Mattia Arrigo
On behalf of the FROG ICU study investigators
Publication date: 01-12-2019
Publisher: Springer International Publishing
Published in: Annals of Intensive Care / Issue 1/2019
Electronic ISSN: 2110-5820
DOI: https://doi.org/10.1186/s13613-019-0514-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Gender and survival of critically ill patients: results from the FROG-ICU study

Abstract

Purpose

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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