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Cancer Chemotherapy and Pharmacology
Published in: Cancer Chemotherapy and Pharmacology 5/2014

Open Access 01-11-2014 | Review Article

GEIS 2013 guidelines for gastrointestinal sarcomas (GIST)

Authors: Andrés Poveda, Xavier García del Muro, Jose Antonio López-Guerrero, Virginia Martínez, Ignacio Romero, Claudia Valverde, Ricardo Cubedo, Javier Martín-Broto

Published in: Cancer Chemotherapy and Pharmacology | Issue 5/2014

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Abstract

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal soft tissue sarcoma of the gastrointestinal tract. Correct diagnosis with thorough use of pathologic and molecular tools of GIST mutations has been of the foremost importance. GIST are usually (95 %) KIT positive and harbor frequent KIT or platelet-derived growth factor receptor α-activating mutations. This deep molecular understanding has allowed the correct classification into risk groups with implications regarding prognosis, essential use in the development of targeted therapies and even response prediction to this drugs. Treatment has been evolving and an update to include lessons learned from recent trials in advanced disease as well as controversies in the adjuvant setting that are changing daily practice, is reviewed here. An effort from the Spanish Group for Sarcoma Research with investigators from the group has been undertaken to launch this third version of the GIST guidelines and provide a practical means for the different disciplines that treat this complex disease.
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Metadata
Title
GEIS 2013 guidelines for gastrointestinal sarcomas (GIST)
Authors
Andrés Poveda
Xavier García del Muro
Jose Antonio López-Guerrero
Virginia Martínez
Ignacio Romero
Claudia Valverde
Ricardo Cubedo
Javier Martín-Broto
Publication date
01-11-2014
Publisher
Springer Berlin Heidelberg
Published in
Cancer Chemotherapy and Pharmacology / Issue 5/2014
Print ISSN: 0344-5704
Electronic ISSN: 1432-0843
DOI
https://doi.org/10.1007/s00280-014-2547-0

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