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01-10-2019 | Original Article

Gated SPECT myocardial perfusion imaging with cadmium-zinc-telluride detectors allows real-time assessment of dobutamine-stress-induced wall motion abnormalities

Authors: Rene Nkoulou, MD, Mathias Wolfrum, MD, Aju P. Pazhenkottil, MD, Michael Fiechter, MD, Ronny R. Buechel, MD, Oliver Gaemperli, MD, Philipp A. Kaufmann, MD

Published in: Journal of Nuclear Cardiology | Issue 5/2019

Abstract

Background

Left ventricular (LV) ejection fraction (EF) during high dobutamine stress (HD) by real-time gated-SPECT myocardial perfusion imaging (MPI) on a cadmium-zinc-telluride (CZT) gamma camera was validated versus cardiac magnetic resonance imaging (CMR).

Methods and results

After injecting 99mTc-tetrofosmin (320 MBq) in 50 patients (mean age 64 +/− 11 years), EF at rest and post-stress as well as relevant changes in EF at HD (ΔEF ≥ 5%) were assessed. CZT and CMR rest EF values yielded an excellent correlation and agreement (r = 0.96; P < 0.001; Bland–Altman limits of agreement (BA): + 0 to 14.8%). HD EF acquisition was feasible using CZT and correlated better to HD CMR EF than did post-stress CZT EF (r = 0.85 vs 0.76, respectively, all P < 0.001). Agreement in ΔEF detection between HD CMR and immediate post-stress CZT (reflecting standard acquisition using conventional SPECT camera unable to scan during stress) was 45%, while this increased to 85% with real-time HD CZT scan.

Conclusion

Real-time ultrafast dobutamine gated-SPECT MPI with a CZT device is feasible and provides accurate measurements of HD LV performance.

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Title: Gated SPECT myocardial perfusion imaging with cadmium-zinc-telluride detectors allows real-time assessment of dobutamine-stress-induced wall motion abnormalities
Authors: Rene Nkoulou, MD
Mathias Wolfrum, MD
Aju P. Pazhenkottil, MD
Michael Fiechter, MD
Ronny R. Buechel, MD
Oliver Gaemperli, MD
Philipp A. Kaufmann, MD
Publication date: 01-10-2019
Publisher: Springer International Publishing
Published in: Journal of Nuclear Cardiology / Issue 5/2019
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-018-1187-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Gated SPECT myocardial perfusion imaging with cadmium-zinc-telluride detectors allows real-time assessment of dobutamine-stress-induced wall motion abnormalities

Abstract

Background

Methods and results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods and results

Conclusion

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