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BMC Pediatrics
Published in: BMC Pediatrics 1/2023

Open Access 01-12-2023 | Gastritis | Case report

Helicobacter bizzozeronii infection in a girl with severe gastric disorders in México: case report

Authors: Ericka Montijo-Barrios, Omaha Y. Celestino-Pérez, Luis Morelia-Mandujano, Cesar Mauricio Rojas-Maruri, Annemieke Smet, Freddy Haesebrouck, Chloë De Witte, Carolina Romo-González

Published in: BMC Pediatrics | Issue 1/2023

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Abstract

Background

Gastric non-Helicobacter pylori helicobacters (NHPH) naturally colonize the stomach of animals. In humans, infection with these bacteria is associated with chronic active gastritis, peptic ulceration and MALT-lymphoma. H. bizzozeronii belongs to these NHPH and its prevalence in children is unknown.

Case presentation

This case report describes for the first time a NHPH infection in a 20-month-old girl with severe gastric disorders in Mexico. The patient suffered from melena, epigastric pain, and bloating. Gastroscopy showed presence of a Hiatus Hill grade I, a hemorrhagic gastropathy in the fundus and gastric body, and a Forrest class III ulcer in the fundus. Histopathologic examination revealed a chronic active gastritis with presence of long, spiral-shaped bacilli in the glandular lumen. Biopsies from antrum, body and incisure were negative for presence of H. pylori by culture and PCR, while all biopsies were positive for presence of H. bizzozeronii by PCR. Most likely, infection occurred through intense contact with the family dog. The patient received a triple therapy consisting of a proton pump inhibitor, clarithromycin, and amoxicillin for 14 days, completed with sucralfate for 6 weeks, resulting in the disappearance of her complaints.

Conclusion

The eradication could not be confirmed, although it was suggested by clear improvement of symptoms. This case report further emphasizes the zoonotic importance of NHPH. It can be advised to routinely check for presence of both H. pylori and NHPH in human patients with gastric complains.
Literature
1.
2.
Øverby A, Murayama SY, Michimae H, Suzuki H, Suzuki M, Serizawa H, Tamura R, Nakamura S, Takahashi S, Nakamura M. Prevalence of gastric non-Helicobacter pylori-Helicobacters in Japanese patients with gastric disease. Digestion. 2017;95:61–6.CrossRefPubMed
3.
Haesebrouck F, Pasmans F, Flahou B, Chiers K, Baele M, Meyns T, Decostere A, Ducatelle R. Gastric helicobacters in domestic animals and nonhuman primates and their significance for human health. Clin Microbiol Rev. 2009;22:202–23.CrossRefPubMedPubMedCentral
4.
Haesebrouck F, Pasmans F, Flahou B, Smet A, Vandamme P, Ducatelle R. Non-Helicobacter pylori Helicobacter species in the human gastric mucosa: a proposal to introduce the terms H. heilmannii sensu lato and sensu stricto. Helicobacter. 2011;16:339–40.CrossRefPubMed
5.
De Groote D, Van Doorn LJ, Van den Bulck K, Vandamme P, Vieth M, Stolte M, Debongnie JC, Burette A, Haesebrouck F, Ducatelle R. Detection of non-pylori Helicobacter species in “Helicobacter heilmannii”-infected humans. Helicobacter. 2005;10:398–406.CrossRefPubMed
6.
Yakoob J, Abbas Z, Khan R, Naz S, Ahmad Z, Islam M, Awan S, Jafri F, Jafri W. Prevalence of non Helicobacter pylori species in patients presenting with dyspepsia. BMC Gastroenterol. 2012;12: 3.CrossRefPubMedPubMedCentral
7.
Liu J, He L, Haesebrouck F, Gong Y, Flahou B, Cao Q, Zhang J. Prevalence of coinfection with gastric non-Helicobacter pylori Helicobacter (NHPH) species in Helicobacter pylori-infected patients suffering from gastric disease in Beijing, China. Helicobacter. 2015;20:284–90.CrossRefPubMed
8.
Sykora J, Hejda V, Varvarovska J, Stozicky F, Gottrand F, Siala K. Helicobacter heilmannii” related gastric ulcer in childhood. J Pediatr Gastroenterol Nutr. 2003;36:410–3.CrossRefPubMed
9.
Boyanova L, Lazarova E, Jelev C, Gergova G, Mitov I. Helicobacter pylori and Helicobacter heilmannii in untreated bulgarian children over a period of 10 years. J Med Microbiol. 2007;56:1081–5.CrossRefPubMed
10.
Iwanczak B, Biernat M, Iwanczak F, Grabinska J, Matusiewicz K, Gosciniak G. The clinical aspects of Helicobacter heilmannii infection in children with dyspeptic symptoms. J Physiol Pharmacol. 2012;63:133–6.PubMed
11.
Matsumoto T, Kawakubo M, Akamatsu T, Koide N, Ogiwara N, Kubota S, Sugano M, Kawakami Y, Katsuyama T, Ota H. Helicobacter heilmannii sensu stricto-related gastric ulcers: a case report. World J Gastroenterol. 2014;20:3376–82.CrossRefPubMedPubMedCentral
12.
13.
Ghysen K, Smet A, Denorme P, Vanneste G, Haesebrouck F, Van Moerkercke W. An atypical presentation of an acute gastric Helicobacter felis infection. Acta Gastroenterol Belg. 2018;81:436–8.PubMed
14.
Nakagawa S, Shimoyama T, Nakamura M, Chiba D, Kikuchi H, Sawaya M, Chinda D, Mikami T, Fukuda S. The resolution of Helicobacter suis-associated gastric lesions after eradication therapy. Intern Med. 2018;57:203–7.CrossRefPubMed
15.
Bahadori A, De Witte C, Agin M, De Bruyckere S, Smet A, Tümgör G, Güven GT, Haesebrouck F, Köksal F. Presence of gastric Helicobacter species in children suffering from gastric disorders in Southern Turkey. Helicobacter. 2018;23:e12511.CrossRef
16.
Chen IC, Hung MS, Chiu TF, Chen JC, Hsiao CT. Risk scoring systems to predict need for clinical intervention for patients with nonvariceal upper gastrointestinal tract bleeding. Am J Emerg Med. 2007;25:774–9.CrossRefPubMed
17.
Sharaf RN, Shergill AK, Odze RD, Krinsky ML, Fukami N, Jain R, Appalaneni V, Anderson MA, BenMenachem T, Chandrasekhara V, Chathadi K, Decker GA, Early D, Evans JA, Fanelli RD, Fisher DA, Fisher LR, Foley KQ, Hwang JH, Jue TL, Ikenberry SO, Khan KM, Lightdale J, Malpas PM, Maple JT, Pasha SF, Saltzman J, Dominitz JA, Cash BD. Endoscopic mucosal tissue sampling’. Gastrointest Endosc. 2013;8:216–24.CrossRef
18.
Romo-González C, Consuelo-Sánchez A, Camorlinga-Ponce M, Velázquez-Guadarrama N, García-Zúñiga M, Burgueño-Ferreira J, Coria-Jiménez R. Plasticity region genes jhp0940, jhp0945, jhp0947, and jhp0949 of Helicobacter pylori in isolates from mexican children. Helicobacter. 2015;20:231–7.CrossRefPubMed
19.
Lu JJ, Perng CL, Shyu RY, Chen CH, Lou Q, Chong SK, Lee CH. Comparison of five PCR methods for detection of Helicobacter pylori DNA in gastric tissues. J Clin Microbiol. 1999;37:772–4.CrossRefPubMedPubMedCentral
20.
Peek RM Jr, Miller GG, Tham KT, Perez-Perez GI, Cover TL, Atherton JC, Dunn GD, Blaser MJ. Detection of Helicobacter pylori gene expression in human gastric mucosa. J Clin Microbiol. 1995;33:28–32.CrossRefPubMedPubMedCentral
21.
Amorim I, Smet A, Alves O, Teixeira S, Saraiva AL, Taulescu M, Gärtner F. Presence and significance of Helicobacter spp. In the gastric mucosa of portuguese dogs. Gut pathogens. 2015;7:12.CrossRefPubMedPubMedCentral
22.
Duquenoy A, Le Luyer B. Gastritis caused by Helicobacter heilmannii probably transmitted from dog to child. Arch Pediatr. 2009;16:426–9.CrossRefPubMed
23.
De Bock M, Van Den Bulck K, Hellemans A, Daminet S, Coche JC, Debongnie JC, Decostere A, Haesebrouck F, Ducatelle R. Peptic ulcer disease associated with Helicobacter felis in a dog owner. Eur J Gastroen Hepat. 2007;19:79–82.CrossRef
24.
Kato S, Ozawa K, Sekine H, Ohyauchi M, Shimosegawa T, Minoura T, Iinuma K. Helicobacter heilmannii infection in a child after successful eradication of Helicobacter pylori: case report and review of literature. J Gastroenterol. 2005;40:94–7.CrossRefPubMed
25.
Yoshimura M, Isomoto H, Shikuwa S, Osabe M, Matsunaga K, Omagari K, Mizuta Y, Murase K, Murata I, Kohno S. A case of acute gastric mucosal lesions associated with “Helicobacter heilmannii” infection. Helicobacter. 2002;7:322–6.CrossRefPubMed
26.
Jalava K, On SL, Harrington CS, Andersen LP, Hanninen ML, Vandamme P. A cultured strain of “Helicobacter heilmannii”, a human gastric pathogen, identified as H. bizzozeronii: evidence for zoonotic potential of Helicobacter. Emerg Infect Dis. 2001;2001(7):1036–8.CrossRef
27.
Kivisto R, Linros J, Rossi M, Rautelin H, Hanninen ML. Characterization of multiple Helicobacter bizzozeronii isolates from a finnish patient with severe dyspeptic symptoms and chronic active gastritis. Helicobacter. 2010;15:58–66.CrossRefPubMed
28.
Dieterich C, Wiesel P, Neiger R, Blum A, Corthesy-Theulaz I. Presence of multiple “Helicobacter heilmannii” strains in an individual suf- fering from ulcers and in his two cats. J Clin Microbiol. 1998;36:1366–70.CrossRefPubMedPubMedCentral
29.
Van den Bulck K, Decostere A, Gruntar I, Baele M, Krt B, Ducatelle R, Haesebrouck F. In vitro antimicrobial susceptibility testing of Helicobacter felis, H. bizzozeronii, and H. salomonis. Antimicrob Agents Chemother. 2005;49:2997–3000.CrossRefPubMedPubMedCentral
30.
Kubota-Aizawa S, Ohno K, Fukushima K, Kanemoto H, Nakashima K, Uchida K, Chambers JK, Goto-Koshino Y, Watanabe T, Sekizaki T, Mimuro H, Tsujimoto H. Epidemiological study of gastric Helicobacter spp. in dogs with gastrointestinal disease in Japan and diversity of Helicobacter heilmannii sensu stricto. Vet J. 2017;225:56–62.CrossRefPubMed
31.
Chung TH, Kim HD, Lee YS, Hwang CY. Determination of the prevalence of Helicobacter heilmannii-like organisms type 2 (HHLO‐2) infection in humans and dogs using non‐invasive genus/species‐specific PCR in Korea. J Vet Med Sci. 2014;76:73–9.CrossRefPubMed
32.
33.
Svec A, Kordas P, Pavlis Z, Novotny J. High prevalence of Helicobacter heilmannii-associated gastritis in a small, predominantly rural area: further evidence in support of a zoonosis? Scand J Gastroenterol. 2000;35:925–8.CrossRefPubMed
34.
Stolte M, Wellens E, Bethke B, Ritter M, Eidt H. Helicobacter heilmannii (formerly gastrospirillum hominis) gastritis: an infection transmitted by animals? Scand J Gastroenterol. 1994;29:1061–4.CrossRefPubMed
35.
Berlamont H, Joosten M, Ducatelle R, Haesebrouck F, Smet A. Presence of gastric Helicobacter spp. in feces and saliva from dogs and cats. Vlaams Diergeneeskundig Tijdschrif. 2017;86:73–8.CrossRef
36.
Azevedo NF, Almeida C, Fernandes I, Cerqueira L, Dias S, Keevil CW, Vieira MJ. Survival of gastric and enterohepatic Helicobacter spp. in water: implications for transmission. Appl Environ Microbiol. 2008;74:1805–11.CrossRefPubMedPubMedCentral
37.
Qualia CM, Katzman PJ, Brown MR, Kooros K. A report of two children with Helicobacter heilmannii gastritis and review of the literature. Pediatr Dev Pathol. 2007;10:391–4.CrossRefPubMed
38.
García Varona A, Pisabarros Blanco C. Gastritis por Helicobacter heilmannii sensu lato: descripción de un caso y revisión de la literatura. Revista Española de Patología. 2016;49:37–40 ISSN 1699–8855.CrossRef
39.
Joosten M, Blaecher C, Flahou B, Ducatelle R, Haesebrouck F, Smet A. Diversity in bacterium-host interactions within the species Helicobacter heilmannii sensu stricto. Vet Res. 2013;44: 65.CrossRefPubMedPubMedCentral
40.
41.
Morgner A, Lehn N, Andersen LP, Thiede C, Bennedsen M, Trebesius K, Neubauer B, Neubauer A, Stolte M, Bayerdorffer E. Helicobacter heilmannii-associated primary gastric low-grade MALT lym- phoma: complete remission after curing the infection. Gastroenterology. 2000;118:821–8.CrossRefPubMed
42.
Kaklikkaya N, Ozgur O, Aydin F, Cobanoglu U. Helicobacter heilmannii as causative agent of chronic active gastritis. Scand J Infect Dis. 2002;34:768–70.CrossRefPubMed
Metadata
Title
Helicobacter bizzozeronii infection in a girl with severe gastric disorders in México: case report
Authors
Ericka Montijo-Barrios
Omaha Y. Celestino-Pérez
Luis Morelia-Mandujano
Cesar Mauricio Rojas-Maruri
Annemieke Smet
Freddy Haesebrouck
Chloë De Witte
Carolina Romo-González
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2023
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-023-04142-7

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