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01-12-2020 | Gastric Cancer | Review Article

The role of bursectomy in the surgical management of gastric cancer: a meta-analysis and systematic review

Authors: Konstantinos Perivoliotis, Ioannis Baloyiannis, Dimitrios Symeonidis, Konstantinos Tepetes

Published in: Updates in Surgery | Issue 4/2020

Abstract

In order to delineate the exact role of bursectomy (BS) in gastric cancer surgery, we designed and conducted the present meta-analysis. This meta-analysis adhered to the PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. A systematic literature review of the electronic databases (Medline, Scopus, Web of Science) was performed. Trial sequential analysis (TSA) was introduced for the validation of the pooled analyses. The level of evidence was attributed based on the GRADE approach. Overall, nine studies and 3599 patients were included in our meta-analysis. BS did not lead to an increase in the overall morbidity rate (OR 1.17, 95% CI 0.97–1.42, p = 0.09). Equivalence was, also, identified in all specific postoperative complications. Similarly, mortality rates were comparable (p = 0.69). Moreover, BS was related to a significantly higher operative time (p < 0.001) and perioperative blood loss (p = 0.002). Finally, resection of the omental bursa was not associated with improved R0 excision rates (p = 0.92), lymph node harvest (p = 0.1) or survival outcomes (OS p = 0.15 and DFS p = 0.97). BS displayed a suboptimal perioperative performance without any significant oncological efficacy. Due to certain limitations and the low level of evidence, further high-quality RCTs are required.

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Title: The role of bursectomy in the surgical management of gastric cancer: a meta-analysis and systematic review
Authors: Konstantinos Perivoliotis
Ioannis Baloyiannis
Dimitrios Symeonidis
Konstantinos Tepetes
Publication date: 01-12-2020
Publisher: Springer International Publishing
Keywords: Gastric Cancer
Gastric Cancer
Published in: Updates in Surgery / Issue 4/2020
Print ISSN: 2038-131X
Electronic ISSN: 2038-3312
DOI: https://doi.org/10.1007/s13304-020-00801-x

At a glance: The STEP trials

Springer Medicine

The role of bursectomy in the surgical management of gastric cancer: a meta-analysis and systematic review

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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