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Familial Cancer
Published in: Familial Cancer 3/2017

01-07-2017 | Short Communication

Gastric cancer in FAP: a concerning rise in incidence

Authors: Gautam Mankaney, Pamela Leone, Michael Cruise, Lisa LaGuardia, Margaret O’Malley, Amit Bhatt, James Church, Carol A. Burke

Published in: Familial Cancer | Issue 3/2017

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Abstract

The highest cancer risks in familial adenomatous polyposis (FAP) include colorectal, duodenal, and thyroid for which surveillance is recommended. Nearly all patients with FAP have gastric fundic gland polyposis (FGP), but gastric cancers are rarely reported with a similar incidence as the general population. We describe a recent, sudden increase in the incidence of gastric cancer in FAP. Seven of the ten cases were diagnosed in the last 20 months. Comparing our population to the SEER database for gastric cancer, the standardized incidence ratio is 140. All cases arose in patients with a carpeting of FGP and associated with large mounds of proximal gastric polyps. Nearly all patients were under upper endoscopic surveillance. This is a concerning observation and reflects a change in the phenotypic presentation of FAP in Western patients.
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Metadata
Title
Gastric cancer in FAP: a concerning rise in incidence
Authors
Gautam Mankaney
Pamela Leone
Michael Cruise
Lisa LaGuardia
Margaret O’Malley
Amit Bhatt
James Church
Carol A. Burke
Publication date
01-07-2017
Publisher
Springer Netherlands
Published in
Familial Cancer / Issue 3/2017
Print ISSN: 1389-9600
Electronic ISSN: 1573-7292
DOI
https://doi.org/10.1007/s10689-017-9971-3

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