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Obesity Surgery
Published in: Obesity Surgery 12/2015

01-12-2015 | Original Contributions

Gastric Band Surgery Leads to Improved Insulin Secretion in Overweight People with Type 2 Diabetes

Authors: John M. Wentworth, Julie Playfair, Cheryl Laurie, Wendy A. Brown, Paul Burton, Jonathan E. Shaw, Paul E. O’Brien

Published in: Obesity Surgery | Issue 12/2015

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Abstract

Background

We aimed to determine the effects of laparoscopic adjustable gastric band (LAGB) on beta-cell function in overweight people with type 2 diabetes and to assess the relationship between baseline beta-cell function and glycemic outcomes.

Methods

We studied 44 overweight but not obese people with type 2 diabetes who participated in a randomized trial whose primary outcome was the rate of diabetes remission after 2 years of multidisciplinary diabetes care (MDC group) or multidisciplinary care combined with LAGB. Dynamic beta-cell function was assessed by intravenous glucose challenge, and basal beta-cell function (HOMA-B) and insulin sensitivity (HOMA-S) were determined using the homeostatic model.

Results

Twelve LAGB participants and two MDC participants were in diabetes remission at 2 years. HOMA-S and the C-peptide response to intravenous glucose increased significantly in LAGB but not in MDC participants. The insulin response to glucose did not change in LAGB participants, whereas their fasting C-peptide/insulin ratio increased. Baseline measures of beta-cell function correlated with diabetes remission but not with reduction in HbA1c following LAGB.

Conclusions

In overweight people with diabetes, LAGB improves endogenous beta-cell function after 2 years. Baseline beta-cell function correlated with diabetes remission, but not with HbA1c change following LAGB.
Appendix
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Metadata
Title
Gastric Band Surgery Leads to Improved Insulin Secretion in Overweight People with Type 2 Diabetes
Authors
John M. Wentworth
Julie Playfair
Cheryl Laurie
Wendy A. Brown
Paul Burton
Jonathan E. Shaw
Paul E. O’Brien
Publication date
01-12-2015
Publisher
Springer US
Published in
Obesity Surgery / Issue 12/2015
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-015-1716-5

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