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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2020

01-12-2020 | Gastrectomy | ASO Author Reflections

ASO Author Reflections: Future Prospects of Neoadjuvant Chemotherapy for Gastric Cancer

Authors: Masayuki Kano, MD, PhD, Hisahiro Matsubara, MD, PhD

Published in: Annals of Surgical Oncology | Special Issue 3/2020

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Excerpt

Gastrectomy with D2 lymphadenectomy with or without adjuvant chemotherapy for locally advanced gastric cancer is a standard treatment strategy in eastern Asia. However, patients’ prognosis of novel therapeutic strategy for locally advanced gastric cancer have been shown to have further reformability than standard D2 gastrectomy and adjuvant chemotherapy. In Japan, postoperative S-1 monotherapy for 1 year or capecitabine plus oxaliplatin for 6 months have been recognized for national insurance as standard therapy, and the selection of these two regimens for postoperative therapy is entrusted for the physicians. It has been widely considered that neoadjuvant chemotherapy (NAC) has several advantages over adjuvant settings in Japan. However, NAC has very limited evidence in Japan.1 …
Literature
1.
Tsuburaya A, Mizusawa J, Tanaka Y, et al. Neoadjuvant chemotherapy with S-1 and cisplatin followed by D2 gastrectomy with para-aortic lymph node dissection for gastric cancer with extensive lymph node metastasis. Br J Surg. 2014;101(6):653–60.CrossRef
2.
Iwasaki Y, Terashima M, Mizusawa J, et al. Randomized phase III trial of gastrectomy with or without neoadjuvant S-1 plus cisplatin for type 4 or large type 3 gastric cancer: Japan Clinical Oncology Group study (JCOG0501). J Clin Oncol. 2018;36(15 suppl):4046CrossRef
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Kodera Y, Yoshida K, Kochi M, et al. A randomized phase III study comparing S-1 plus docetaxel with S-1 alone as a postoperative adjuvant chemotherapy for curatively resected stage III gastric cancer (JACCRO GC-07 trial). J Clin Oncol. 2018;36(15 suppl):4007CrossRef
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Kano M, Hayano K, Hayashi H, et al. Survival benefit of neoadjuvant chemotherapy with S-1 plus docetaxel for locally advanced gastric cancer: a propensity score-matched analysis. Ann Surg Oncol. 2019;26:1805–13.CrossRef
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Yamada Y, Boku N, Mizusawa J, et al. Phase III study comparing triplet chemotherapy with S-1 and cisplatin plus docetaxel versus doublet chemotherapy with S-1 and cisplatin for advanced gastric cancer (JCOG1013). J Clin Oncol. 2018;36(15 suppl):4009CrossRef
Metadata
Title
ASO Author Reflections: Future Prospects of Neoadjuvant Chemotherapy for Gastric Cancer
Authors
Masayuki Kano, MD, PhD
Hisahiro Matsubara, MD, PhD
Publication date
01-12-2020
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2020
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-019-07862-2

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