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01-02-2019 | Original Article

Gallic acid activates hippocampal BDNF-Akt-mTOR signaling in chronic mild stress

Authors: Ji-Xiao Zhu, Jia-Ling Shan, Wei-Qiong Hu, Jin-Xiang Zeng, Ji-Cheng Shu

Published in: Metabolic Brain Disease | Issue 1/2019

Abstract

Gallic acid (3,4,5-trihydroxybenzoic acid) is a naturally occurring polyphenolic compound. Previous study has shown that gallic acid possessed significant antidepressant-like activity in mice, which was partly mediated by increasing serotonin and catecholamine levels. The main aim of the present study is to investigate the possible effects of gallic acid on brain-derived neurotrophic factor (BDNF) signaling activation. Mice were exposed to chronic mild stress (CMS) and orally administrated with gallic acid for four weeks. The behavioral results showed that gallic acid not only reversed the decreased sucrose preference, but also attenuated the increased immobility time. In addition, gallic acid promoted both the BDNF and p-TrkB levels in the hippocampus induced by CMS. Moreover, the results also demonstrated that the inactivated Akt-mTOR signaling pathway, as well as its downstream effectors induced by CMS was activated again by gallic acid. Last, immunofluorescence detection indicated that gallic acid reversed the newborn neurons inhibition in the dentate gyrus by CMS. In conclusion, these results show that the activation of the hippocampal BDNF-Akt-mTOR signaling is involved in the antidepressant-like effects of gallic acid.

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Title: Gallic acid activates hippocampal BDNF-Akt-mTOR signaling in chronic mild stress
Authors: Ji-Xiao Zhu
Jia-Ling Shan
Wei-Qiong Hu
Jin-Xiang Zeng
Ji-Cheng Shu
Publication date: 01-02-2019
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 1/2019
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-018-0328-x

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Springer Medicine

Gallic acid activates hippocampal BDNF-Akt-mTOR signaling in chronic mild stress

Abstract

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Springer Medicine

Abstract

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