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30-06-2022 | Gallbladder Cancer | Review Article

Hepatopancreatoduodenectomy for Locally Advanced Gallbladder Cancer: Is It Worthwhile?

Authors: Yanming Zhou, Dianqi Li, Jun You, Siyuan Zeng, Wenlin Yu

Published in: Indian Journal of Surgery | Special Issue 2/2022

Abstract

The benefit of hepatopancreatoduodenectomy for locally advanced gallbladder cancer was unclear. An electronic search was conducted in PubMed, Ovid, and the Cochrane Library for the relevant publications reported in the literature between January 1990 and November 2021. Twenty-two studies involving 126 patients met the inclusion criteria. Major and minor hepatectomies were performed in 45.6% and 54.4% patients respectively. R0 (microscopically negative margin) resection was achieved in 74.6% patients. The morbidity and 90-day mortality rates were 60.1% and 8.7% respectively. The median overall survival after surgery was 18 months. Multivariate analysis showed that R0 resection was the only independent prognostic factor for survival (hazard ratio 0.115, 95% confidence intervals 0.030–0.445; P = 0.002). Hepatopancreatoduodenectomy was suggested in patients with locally advanced gallbladder cancer provided that R0 resection can be achieved.

Lim CS, Jang JY, Lee SE, Kang MJ, Kim SW (2012) Reappraisal of hepatopancreatoduodenectomy as a treatment modality for bile duct and gallbladder cancer. J Gastrointest Surg 16:1012–1018CrossRef

Aoki T, Sakamoto Y, Kohno Y, Akamatsu N et al (2018) Hepatopancreaticoduodenectomy for biliary cancer: strategies for near-zero operative mortality and acceptable long-term outcome. Ann Surg 267:332–337CrossRef

Toyoda Y, Ebata T, Mizuno T et al (2019) Cholangiographic tumor classification for simple patient selection prior to hepatopancreatoduodenectomy for cholangiocarcinoma. Ann Surg Oncol 26:2971–2979CrossRef

Miwa S, Kobayashi A, Akahane Y et al (2007) Is major hepatectomy with pancreatoduodenectomy justified for advanced biliary malignancy? J Hepatobiliary Pancreat Surg 14:136–141CrossRef

Sakamoto Y, Nara S, Kishi Y et al (2013) Is extended hemihepatectomy plus pancreaticoduodenectomy justified for advanced bile duct cancer and gallbladder cancer? Surg 153:794–800CrossRef

Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:e1000097CrossRef

Strasberg SM (2005) Nomenclature of hepatic anatomy and resections: a review of the Brisbane 2000 system. J Hepatobiliary Pancreat Surg 12:351–355CrossRef

Nimura Y, Hayakawa N, Kamiya J et al (1991) Hepatopancreatoduodenectomy for advanced carcinoma of the biliary tract. Hepatogastroenterology 38:170–175PubMed

Nakamura S, Nishiyama R, Yokoi Y et al (1994) Hepatopancreatoduodenectomy for advanced gallbladder carcinoma. Arch Surg 129:625–629CrossRef

10.

Miyazaki K, Tsutsumi N, Kitahara K et al (1995) Hepatopancreatoduodenectomy for squamous and adenosquamous carcinoma of the gallbladder. Hepatogastroenterology 42:47–50PubMed

11.

Miyagawa S, Makuuchi M, Kawasaki S et al (1996) Outcome of major hepatectomy with pancreatoduodenectomy for advanced biliary malignancies. World J Surg 20:77–80CrossRef

12.

Shirai Y, Ohtani T, Tsukada K, Hatakeyama K (1997) Combined pancreaticoduodenectomy and hepatectomy for patients with locally advanced gallbladder carcinoma: long term results. Cancer 80:1904–1909CrossRef

13.

Tomono H, Fujioka S, Kato K, Aikawa K, Nimura Y (2000) Hepatopancreatoduodenectomy for squamous cell carcinoma of the gallbladder. Hepatogastroenterology 47:945–947PubMed

14.

Iwahashi N, Hayakawa N, Yamamoto H et al (2001) Advanced gallbladder carcinoma with biliobiliary fistula, resected by hepatopancreatoduodenectomy, in an aged patient. J Hepatobiliary Pancreat Surg 8:287–290CrossRef

15.

Sasaki R, Takahashi M, Funato O et al (2002) Hepatopancreatoduodenectomy with wide lymph node dissection for locally advanced carcinoma of the gallbladder–long-term results. Hepatogastroenterology 49:912–915PubMed

16.

Tanaka A, Kataoka M, Yamamoto H, Takeda R, Mukaihara S, Yamaoka Y (2001) Extreme discrepancy between macroscopic diagnosis and pathological findings of gallbladder cancer treated by hepatopancreatoduodenectomy. J Hepatobiliary Pancreat Surg 8:101–106CrossRef

17.

Doty JR, Cameron JL, Yeo CJ, Campbell K, Coleman J, Hruban RH (2002) Cholecystectomy, liver resection, and pylorus-preserving pancreaticoduodenectomy for gallbladder cancer: report of five cases. J Gastrointest Surg 6:776–780CrossRef

18.

Oohashi Y, Shirai Y, Wakai T, Nagakura S, Watanabe H, Hatakeyama K (2002) Adenosquamous carcinoma of the gallbladder warrants resection only if curative resection is feasible. Cancer 94:3000–30005CrossRef

19.

D’Angelica M, Martin RC 2nd, Jarnagin WR, Fong Y, DeMatteo RP, Blumgart LH (2004) Major hepatectomy with simultaneous pancreatectomy for advanced hepatobiliary cancer. J Am Coll Surg 198:570–576CrossRef

20.

Hirono S, Tani M, Kawai M, Ina S, Uchiyama K, Yamaue H (2006) Indication of hepatopancreatoduodenectomy for biliary tract cancer. World J Surg 30:567–573CrossRef

21.

Principe A, Del Gaudio M, Ercolani G, Golfieri R, Cucchetti A, Pinna AD (2006) Radical surgery for gallbladder carcinoma: possibilities of survival. Hepatogastroenterology 53:660–664PubMed

22.

Kaneoka Y, Yamaguchi A, Isogai M (2007) Hepatopancreatoduodenectomy: its suitability for bile duct cancer versus gallbladder cancer. J Hepatobiliary Pancreat Surg 14:142–148CrossRef

23.

Nanashima A, Nagasaki T, Sumida Y et al (2008) An experience of hepatopancreatoduodenectomy in patients with hepatobiliary malignancies. Hepatogastroenterology 55:1691–1694PubMed

24.

Wakai T, Shirai Y, Tsuchiya Y, Nomura T, Akazawa K, Hatakeyama K (2008) Combined major hepatectomy and pancreaticoduodenectomy for locally advanced biliary carcinoma: long-term results. World J Surg 32:1067–1074CrossRef

25.

Utsumi M, Sadamori H, Shinoura S et al (2014) Risk factors of morbidity and predictors of long-term survival after hepatopancreatoduodenectomy for biliary cancer. Hepatogastroenterology 61:2167–2172PubMed

26.

Dai WC, Chok KS, Cheung TT et al (2017) Hepatopancreatoduodenectomy for advanced hepatobiliary malignancies: a single-center experience. Hepatobiliary Pancreat Dis Int 16:382–386CrossRef

27.

Kamada Y, Hori T, Yamamoto H et al (2020) Surgical treatment of gallbladder cancer: An eight-year experience in a single center. World J Hepatol 12:641–660CrossRef

28.

James M, Kalayarasan R, Gnanasekaran S, Pottakkat B (2021) Laparoscopic hepatopancreatoduodenectomy for locally advanced gall bladder cancer. J Minim Access Surg 17:369–372CrossRef

29.

Kuipers H, de Savornin Lohman EAJ, van Dooren M et al (2021) Extended Resections for Advanced Gallbladder Cancer: Results from a Nationwide Cohort Study. Ann Surg Oncol 28:835–843CrossRef

30.

Creasy JM, Goldman DA, Dudeja V et al (2017) Systemic chemotherapy combined with resection for locally advanced gallbladder carcinoma: surgical and survival outcomes. J Am Coll Surg 224:906–916CrossRef

31.

Kim J, Ryu JK, Kim C, Paeng JC, Kim YT (2014) Is there any role of positron emission tomography computed tomography for predicting resectability of gallbladder cancer? J Korean Med Sci 29:680–684CrossRef

32.

Weber SM, DeMatteo RP, Fong Y, Blumgart LH, Jarnagin WR (2002) Staging laparoscopy in patients with extrahepatic biliary carcinoma. Analysis of 100 patients. Ann Surg 235:392–399CrossRef

33.

Fleming FJ, Påhlman L, Monson JR (2011) Neoadjuvant therapy in rectal cancer. Dis Colon Rectum 54:901–912CrossRef

34.

Schorn S, Demir IE, Reyes CM et al (2017) The impact of neoadjuvant therapy on the histopathological features of pancreatic ductal adenocarcinoma - A systematic review and meta-analysis. Cancer Treat Rev 55:96–106CrossRef

35.

Sirohi B, Mitra A, Jagannath P et al (2015) Neoadjuvant chemotherapy in patients with locally advanced gallbladder cancer. Future Oncol 11:1501–1509CrossRef

36.

Engineer R, Goel M, Chopra S et al (2016) Neoadjuvant chemoradiation followed by surgery for locally advanced gallbladder cancers: a new paradigm. Ann Surg Oncol 23:3009–3015CrossRef

37.

Kim SH, Chong JU, Lim JH et al (2016) Optimal assessment of lymph node status in gallbladder cancer. Eur J Surg Oncol 42:205–210CrossRef

38.

Tsukada K, Hatakeyama K, Kurosaki I et al (1996) Outcome of radical surgery for carcinoma of the gallbladder according to the TNM stage. Surgery 120:816–821CrossRef

39.

D’Angelica M, Dalal KM, DeMatteo RP, Fong Y, Blumgart LH, Jarnagin WR (2009) Analysis of the extent of resection for adenocarcinoma of the gallbladder. Ann Surg Oncol 16:806–816CrossRef

Title: Hepatopancreatoduodenectomy for Locally Advanced Gallbladder Cancer: Is It Worthwhile?
Authors: Yanming Zhou
Dianqi Li
Jun You
Siyuan Zeng
Wenlin Yu
Publication date: 30-06-2022
Publisher: Springer India
Keywords: Gallbladder Cancer
Pancreatoduodenostomy
Pancreatoduodenostomy
Gallbladder Cancer
Published in: Indian Journal of Surgery / Issue Special Issue 2/2022
Print ISSN: 0972-2068
Electronic ISSN: 0973-9793
DOI: https://doi.org/10.1007/s12262-022-03471-8

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Hepatopancreatoduodenectomy for Locally Advanced Gallbladder Cancer: Is It Worthwhile?

Abstract

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Abstract

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