Published in:
01-09-2004 | Oral presentation
Galectin-3 in osteoarthritis: from a protective to a destructive role
Authors:
C Boileau, J Martel-Pelletier, M Guévremont, J-P Pelletier, F Poirier, P Reboul
Published in:
Arthritis Research & Therapy
|
Special Issue 3/2004
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Excerpt
Osteoarthritic (OA) chondrocytes are able to re-express numerous genes normally activated in the growth plate, and more particularly in the hypertrophic zone. Among several genes, we are interested in studying galectin-3 (gal-3) since we have recently demonstrated that its expression was increased in OA cartilage [
1]. gal-3 is a mammalian lectin, which interacts with β-galactoside residues and is involved in numerous functions such as adhesion, splicing activity, cell cycle regulation, as well as a receptor for advanced glycation end products (AGE receptor). These functions are related to the gal-3 cellular localization. Indeed, this protein may be found in the plasma membrane, in cytoplasm and in the nucleus. …
