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Open Access 01-12-2017 | Vascular-Interventional

Gadobutrol versus gadofosveset-trisodium in MR venography of the lower extremities

Authors: Carsten W. K. P. Arnoldussen, Yeelai Lam, Nobutake Ito, Bjorn Winkens, M. Eline Kooi, Cees H. A. Wittens, Joachim E. Wildberger

Published in: European Radiology | Issue 12/2017

Abstract

Objectives

MR venography (MRV) protocols have used bloodpool contrast agents and long scan sequences to identify patients suitable for treatment and preoperatively. However, variable availability of bloodpool contrast agents, high costs and a need to shorten acquisition times for routine MR protocols hamper everyday practice.

Materials

20 patients (11 men; mean age 54 ± 11.8 years; body mass index 23.6 ± 2.5) were enrolled in this prospective study. An intra-individual comparison of image quality, interpretation and findings for two different contrast agents (regular gadolinium contrast agent gadobutrol vs. bloodpool contrast agent gadofosveset-trisodium) and two different scan protocols (long acquisition time protocol using a high-resolution fast field echo (FFE) sequence vs. short acquisition time protocol using an ultra-fast gradient echo (GE) sequence) were performed.

Results

Image quality (average of 4.94 vs. 4.92 on a five-point scale), interpretation and contrast-to-noise ratio (44 vs. 45) were equal for both contrast agents. Image findings showed no statistical significant differences between the MR protocols or contrast agents (overall p = 0.328).

Conclusions

For high-resolution MRV, it is possible to replace gadofosveset-trisodium with gadobutrol. Furthermore, an ultra-fast GE sequence for MRV might considerably shorten acquisition time, without loss of image quality or diagnostic yield.

Key Points

• High-quality MRV can be performed with a regular gadolinium-based contrast agent.

• Ultra-fast GRE vs. HR-FFE MRV: equally suitable for evaluation of venous obstruction.

• Regular gadolinium-based contrast agent can supersede a bloodpool contrast agent for MRV.

• Equal confidence for gadobutrol vs gadofosveset-trisodium in MRV.

• MRV accessible for routine daily practice.

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Title: Gadobutrol versus gadofosveset-trisodium in MR venography of the lower extremities
Authors: Carsten W. K. P. Arnoldussen
Yeelai Lam
Nobutake Ito
Bjorn Winkens
M. Eline Kooi
Cees H. A. Wittens
Joachim E. Wildberger
Publication date: 01-12-2017
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 12/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-4902-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Gadobutrol versus gadofosveset-trisodium in MR venography of the lower extremities

Abstract

Objectives

Materials

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials

Results

Conclusions

Key Points

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