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Published in:

01-07-2005

Fusion Image of Positron Emission Tomography and Computed Tomography for the Diagnosis of Local Recurrence of Rectal Cancer

Authors: Hiroki Fukunaga, MD, Mitsugu Sekimoto, MD, PhD, Masataka Ikeda, MD, PhD, Ichiro Higuchi, MD, Masayoshi Yasui, MD, Iwao Seshimo, MD, Osamu Takayama, MD, Hirofumi Yamamoto, MD, PhD, Masayuki Ohue, MD, PhD, Mitsuaki Tatsumi, MD, PhD, Jun Hatazawa, MD, PhD, Masakazu Ikenaga, MD, PhD, Tsunehiko Nishimura, MD, PhD, Morito Monden, MD, PhD

Published in: Annals of Surgical Oncology | Issue 7/2005

Abstract

Background

The aim of this study was to evaluate the clinical and therapeutic value of digital fusion image (FI) of positron emission tomography (PET) using ¹⁸F-fluorodeoxy glucose and computed tomography (CT) in patients who were suspected of having a local recurrence of rectal cancer.

Methods

Forty-two patients (32 men and 10 women; mean age, 61.4 years, range, 40–79 years) with a suspicion of local recurrence after curative resection of rectal cancer were prospectively recruited and underwent ¹⁸F-fluorodeoxy glucose-PET and CT. The FI was reconstructed with a commercially available digital software program, T-B Fusion. Wilcoxon signed rank test was used to compare FI with CT alone or PET alone.

Results

FI yielded a correct diagnosis in 39 (93%) of 42 patients, whereas CT alone and PET alone did so in 33 (79%) and 37 (88%) patients, respectively. FI had better diagnostic accuracy than CT alone (P = .0138) and PET alone (P = .0156). Overall, FI altered patient management in 11 (26.2%) patients on the basis of additional information, including differentiation of the tumor from the postoperative scar in 6 patients, exact anatomical location in 3 patients, and both in 2 patients.

Conclusions

FI has a potential clinical value in the treatment of suspected local recurrence of rectal cancer.

Goldsmith, SJ, Kostakoglu, L 2002 Nuclear medicine in the diagnosis, management of colorectal cancerSaltz, LB eds. Colorectal Cancer: Multimodality ManagementHumana PressTotowa, NJ157177

Wanebo, HJ, Koness, RJ, Vezeridis, MP, Cohen, SI, Wrobleski, DE 1994Pelvic resection of recurrent rectal cancerAnn Surg22058695PubMed

Suzuki, K, Dozois, RR, Devine, RM, et al. 1996Curative reoperations for locally recurrent rectal cancerDis Colon Rectum397306PubMed

Freeny, PC, Marks, WM, Ryan, JA, Bolen, JW 1986Colorectal carcinoma evaluation with CT. preoperative staging and detection of postoperative recurrenceRadiology15834753PubMed

Chen, YM, Ott, DJ, Wolfman, NT, Gelfand, DW, Karsteadt, N, Bechtold, RE 1987Recurrent colorectal carcinoma: evaluation with barium enema examination and CTRadiology16330710PubMed

Moss, AA, Thoeni, RF, Schnyder, P, Margulis, AR 1981Value of computed tomography in the detection and staging of recurrent rectal carcinomasJ Comput Assist Tomogr58704PubMed

Krestin, GP, Steinbrich, W, Friedmann, G 1988Recurrent rectal cancer: diagnosis with MR imaging versus CTRadiology16830711PubMed

Lange, EE, Fechner, RE, Wanebo, HJ 1989Suspected recurrent rectosigmoid carcinoma after abdominoperineal resection: MR imaging and histopathologic findingsRadiology1703238PubMed

Ito, K, Kato, T, Tadokoro, M, et al. 1992Recurrent rectal cancer and scar: differentiation with PET and MR imagingRadiology18254952PubMed

10.

Schlag, P, Lehner, B, Strauss, LG, Georgi, P, Herfarth, C 1989Scar or recurrent rectal cancerPositron emission tomography is more helpful for diagnosis than immunoscintigraphy. Arch Surg 124197200

11.

Keogan, MT, Lowe, VJ, Baker, ME, McDermott, VG, Lyerly, HK, Coleman, RE 1997Local recurrence of rectal cancer: evaluation with F-18 fluorodeoxyglucose PET imagingAbdom Imaging223327CrossRefPubMed

12.

Fukunaga, H, Sekimoto, M, Tatsumi, M, et al. 2002Clinical relevance of fusion images using ¹⁸F-2-fluoro-2-deoxy-D-glucose positron emission tomography in local recurrence of rectal cancerInt J Oncol206915PubMed

13.

Lardinois, D, Weder, W, Hany, TF, et al. 2003Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomographyN Engl J Med34825007PubMed

14.

Hany, TF, Steinert, HC, Goerres, GW, Buck, A, von Schulthess , GK 2002PET diagnostic accuracy: improvement with in-line PET-CT system: initial resultsRadiology22557581PubMed

15.

Townsend, DW, Beyer, T 2002A combined PET/CT scanner: the path to true image fusionBr J Radiol75S2430PubMed

16.

Takeuchi, O, Saito, N, Koda, K, Sarashina, H, Nakajima, N 1999Clinical assessment of positron emission tomography for the diagnosis of local recurrence in colorectal cancerBr J Surg869327CrossRefPubMed

17.

Strauss, LG, Clorius, JH, Schlag, P, et al. 1989Recurrence of colorectal tumors: PET evaluationRadiology17032932PubMed

18.

Wolf, G, Nicoletti, R, Schultes, G, Schwarz, T, Schaffler, G, Aigner, RM 2003Preoperative image fusion of fluoro-2-deoxy-D-glucose-positron emission tomography and computed tomography data sets in oral maxillofacial carcinomaJ Comput Assist Tomogr2788995CrossRefPubMed

19.

D’Amico, TA, Wong, TZ, Harpole, DH, Brown, SD, Coleman, RE 2002Impact of computed tomography-positron emission tomography fusion in staging patients with thoracic malignanciesAnn Thorac Surg741603CrossRefPubMed

20.

Townsend, DW, Carney, JPJ, Yap, JT, Hall, NC 2004PET/CT today and tomorrowJ Nucl Med454S14SPubMed

21.

Cohade, C, Osman, M, Leal, J, Wahl, RL 2003Direct comparison of ¹⁸F-FDG PET and PET/CT in patients with colorectal carcinomaJ Nucl Med441797803PubMed

22.

Minsky BD. Management of locally unresectable rectal cancer. In: Saltz LB (ed). Colorectal Cancer: Multimodality Management Humana Press, Totowa NJ. 20931.

23.

Saito, N, Koda, K, Takiguchi, N, et al. 2003Curative surgery for local pelvic recurrence of rectal cancerDig Surg201929CrossRefPubMed

24.

Huguier, M, Houry, S, Barrier, A 2001Local recurrence of cancer of the rectumAm J Surg1824379CrossRefPubMed

25.

Farouk, R, Nelson, H, Radice, E, Mercill, S, Gunderson, L 1998Accuracy of computed tomography in determining resectability for locally advanced primary or recurrent colorectal cancersAm J Surg1752837CrossRefPubMed

26.

Valk, PE, Abella, CE, Haseman, MK, et al. 1999Whole-body PET imaging with [¹⁸F]fluorodeoxyglucose in management of recurrent colorectal cancerArch Surg13450311CrossRefPubMed

27.

Lonneux, M, Reffad, AM, Detry, R, Kartheuser, A, Gigot, JF, Pauwels, S 2002FDG-PET improves the staging and selection of patients with recurrent colorectal cancerEur J Nucl Med Mol Imaging2991521CrossRefPubMed

28.

Desai, DC, Zervos, EE, Arnold, MW, Burak, WJ, Mantil, J, Martin, EJ 2003Positron emission tomography affects surgical management in recurrent colorectal cancer patientsAnn Surg Oncol105964CrossRefPubMed

29.

Staib, L, Schirrmeister, H, Reske, SN, Beger, HG 2000Is ¹⁸F-fluorodeoxyglucose positron emission tomography in recurrent colorectal cancer a contribution to surgical decision making?Am J Surg18015CrossRefPubMed

30.

Arulampalam, T, Costa, D, Visvikis, D, Boulos, P, Taylor, I, Ell, P 2001The impact of FDG-PET on the management algorithm for recurrent colorectal cancerEur J Nucl Med28175865CrossRefPubMed

31.

Kalff, V, Hicks, RJ, Ware, RE, Hogg, A, Binns, D, McKenzie, AF 2002The clinical impact of ¹⁸F-FDG PET in patients with suspected or confirmed recurrence of colorectal cancer: a prospective studyJ Nucl Med434929PubMed

32.

Flamen, P Stroobants, S CE et al. 1999Additional value of whole-body positron emission tomography with fluorine-18-2-fluoro-2-deoxy-D-glucose in recurrent colorectal cancerJ Clin Oncol17894901PubMed

33.

Gordon, BA, Flanagan, FL, Dehdashati, F 1997Whole-body positron emission tomography: normal variations, pitfalls, and technical considerationAJR Am J Roentgenol169167580PubMed

Title: Fusion Image of Positron Emission Tomography and Computed Tomography for the Diagnosis of Local Recurrence of Rectal Cancer
Authors: Hiroki Fukunaga, MD
Mitsugu Sekimoto, MD, PhD
Masataka Ikeda, MD, PhD
Ichiro Higuchi, MD
Masayoshi Yasui, MD
Iwao Seshimo, MD
Osamu Takayama, MD
Hirofumi Yamamoto, MD, PhD
Masayuki Ohue, MD, PhD
Mitsuaki Tatsumi, MD, PhD
Jun Hatazawa, MD, PhD
Masakazu Ikenaga, MD, PhD
Tsunehiko Nishimura, MD, PhD
Morito Monden, MD, PhD
Publication date: 01-07-2005
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 7/2005
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/ASO.2005.08.001

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Fusion Image of Positron Emission Tomography and Computed Tomography for the Diagnosis of Local Recurrence of Rectal Cancer

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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