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European Archives of Oto-Rhino-Laryngology

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01-03-2013 | Miscellaneous

Functional variants of MIF, INFG and TFNA genes are not associated with disease susceptibility or hearing loss progression in patients with Ménière’s disease

Authors: Irene Gázquez, Antonia Moreno, Teresa Requena, Jeff Ohmen, Sofia Santos-Perez, Ismael Aran, Andres Soto-Varela, Herminio Pérez-Garrigues, Alicia López-Nevot, Angel Batuecas, Rick A. Friedman, Miguel A. López-Nevot, Jose A. López-Escamez

Published in: European Archives of Oto-Rhino-Laryngology | Issue 4/2013

Abstract

Variability in acute immune response genes could determine susceptibility or prognosis for Ménière′s disease (MD). The cytokines tumor necrosis factor α (TNFα), macrophage migration inhibitory factor (MIF) and interferon γ (INFγ) are proinflammatory cytokines of the innate immune response. These cytokines mediate inflammation and have been previously associated with the inflammatory process in several autoimmune diseases. We investigated the association between functional allelic variants of MIF (rs35688089), IFNG (rs2234688) and TNFA (rs1800629) in patients with MD. In addition to testing these variants for an association with disease, we also tested for an association with clinical aspects of disease progression, such as persistence of vertigo and the sensorineural hearing loss. A total of 580 patients with diagnosis of definite MD, according to the diagnostic scale of the American Academy of Otolaryngology-Head and Neck Surgery, and 552 healthy controls were included. DNA samples from a set of 291 American patients were used to confirm the results obtained in the MIF gene in our Spanish cohort. Although we found a significant association with the allele containing five repeats of CATT within the MIF gene in patients with MD in the Spanish cohort [corrected p = 0.008, OR = 0.69 (95 % CI, 0.54–0.88)], this finding could not be replicated in the American set. Moreover, no genetic associations for variants in either the TNFA or IFNG genes and MD were found. These results support the conclusion that functional variants of MIF, INFG, and TFNA genes are not associated with disease susceptibility or hearing loss progression in patients with MD.

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Title: Functional variants of MIF, INFG and TFNA genes are not associated with disease susceptibility or hearing loss progression in patients with Ménière’s disease
Authors: Irene Gázquez
Antonia Moreno
Teresa Requena
Jeff Ohmen
Sofia Santos-Perez
Ismael Aran
Andres Soto-Varela
Herminio Pérez-Garrigues
Alicia López-Nevot
Angel Batuecas
Rick A. Friedman
Miguel A. López-Nevot
Jose A. López-Escamez
Publication date: 01-03-2013
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 4/2013
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-012-2268-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Functional variants of MIF, INFG and TFNA genes are not associated with disease susceptibility or hearing loss progression in patients with Ménière’s disease

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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