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Published in: Dysphagia 6/2014

01-12-2014 | Original Article

Functional Swallowing Outcomes in Nasopharyngeal Cancer Treated with IMRT at 6 to 42 months Post-Radiotherapy

Authors: Margaret Patterson, Rowena Brain, Ronald Chin, David Veivers, Michael Back, Andrew Wignall, Thomas Eade

Published in: Dysphagia | Issue 6/2014

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Abstract

We sought to evaluate the swallowing function of 18 patients surviving nasopharyngeal cancer, who had been treated using an intensity-modulated radiotherapy (IMRT) protocol designed to minimise functional impairment. We compared the outcomes of a patient-reported oral function score with fiberoptic endoscopic examination of swallow (FEES), Australian Therapy Outcome Measures (AusTOMs) and a measure of trismus. While all patients returned to a fully oral diet, there was ongoing swallow dysfunction characterised by bolus residue and delay, but no aspiration. Dysphagia was of mild or moderate severity on all measures, generally because of the need for texture modification, impaired bolus transit or dysgeusia. There was xerostomia on self-reported measurement combined with reports of behaviours adaptive to xerostomia on AusTOMs; however, salivary functioning was less impaired on FEES. There was no trismus in this cohort. Our cohort lacked the morbidity experienced by cohorts reported in earlier studies, potentially due to the use of IMRT.
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Literature
1.
go back to reference Chen QY, Wen YF, Guo L, Liu H, Huang PY, Mo HY, Li NW, Xiang YQ, Luo DH, Qiu F, Sun R, Deng MQ, Chen MY, Hua YJ, Guo X, Cao KJ, Hong MH, Qian CN, Mai HQ. Concurrent chemoradiotherapy vs radiotherapy alone in stage II nasopharyngeal carcinoma: phase III randomized trial. J Natl Cancer Inst. 2011;103(23):1761–70. doi:10.1093/jnci/djr432.PubMedCrossRef Chen QY, Wen YF, Guo L, Liu H, Huang PY, Mo HY, Li NW, Xiang YQ, Luo DH, Qiu F, Sun R, Deng MQ, Chen MY, Hua YJ, Guo X, Cao KJ, Hong MH, Qian CN, Mai HQ. Concurrent chemoradiotherapy vs radiotherapy alone in stage II nasopharyngeal carcinoma: phase III randomized trial. J Natl Cancer Inst. 2011;103(23):1761–70. doi:10.​1093/​jnci/​djr432.PubMedCrossRef
4.
go back to reference Lazarus CL, Logemann JA, Pauloski BR, Colangelo LA, Kahrilas PJ, Mittal BB, Pierce M. Swallowing disorders in head and neck cancer patients treated with radiotherapy and adjuvant chemotherapy. Laryngoscope. 1996;106(9 Pt 1):1157–66.PubMedCrossRef Lazarus CL, Logemann JA, Pauloski BR, Colangelo LA, Kahrilas PJ, Mittal BB, Pierce M. Swallowing disorders in head and neck cancer patients treated with radiotherapy and adjuvant chemotherapy. Laryngoscope. 1996;106(9 Pt 1):1157–66.PubMedCrossRef
5.
go back to reference Cooper JS, Fu K, Marks J, Silverman S. Late effects of radiation therapy in the head and neck region. Int J Radiat Oncol Biol Phys. 1995;31(5):1141–64.PubMedCrossRef Cooper JS, Fu K, Marks J, Silverman S. Late effects of radiation therapy in the head and neck region. Int J Radiat Oncol Biol Phys. 1995;31(5):1141–64.PubMedCrossRef
6.
go back to reference Nageris B, Lavelle W, Elidan J. Multiple late complications of irradiation treatment of nasopharyngeal carcinoma. Ear Nose Throat J. 1995;74(4):286–8.PubMed Nageris B, Lavelle W, Elidan J. Multiple late complications of irradiation treatment of nasopharyngeal carcinoma. Ear Nose Throat J. 1995;74(4):286–8.PubMed
7.
go back to reference Mahdavi R, Faramarzi E, Mohammad-Zadeh M, Ghaeammaghami J, Jabbari MV. Consequences of radiotherapy on nutritional status, dietary intake, serum zinc and copper levels in patients with gastrointestinal tract and head and neck cancer. Saudi Med J. 2007;28(3):435–40.PubMed Mahdavi R, Faramarzi E, Mohammad-Zadeh M, Ghaeammaghami J, Jabbari MV. Consequences of radiotherapy on nutritional status, dietary intake, serum zinc and copper levels in patients with gastrointestinal tract and head and neck cancer. Saudi Med J. 2007;28(3):435–40.PubMed
8.
go back to reference Hughes PJ, Scott PM, Kew J, Cheung DM, Leung SF, Ahuja AT, van Hasselt CA. Dysphagia in treated nasopharyngeal cancer. Head Neck. 2000;22(4):393–7.PubMedCrossRef Hughes PJ, Scott PM, Kew J, Cheung DM, Leung SF, Ahuja AT, van Hasselt CA. Dysphagia in treated nasopharyngeal cancer. Head Neck. 2000;22(4):393–7.PubMedCrossRef
9.
go back to reference Chang YC, Chen SY, Lui LT, Wang TG, Wang TC, Hsiao TY, Li YW, Lien IN. Dysphagia in patients with nasopharyngeal cancer after radiation therapy: a videofluoroscopic swallowing study. Dysphagia. 2003;18(2):135–43.PubMedCrossRef Chang YC, Chen SY, Lui LT, Wang TG, Wang TC, Hsiao TY, Li YW, Lien IN. Dysphagia in patients with nasopharyngeal cancer after radiation therapy: a videofluoroscopic swallowing study. Dysphagia. 2003;18(2):135–43.PubMedCrossRef
11.
go back to reference Nutting CM, Morden JP, Harrington KJ, Urbano TG, Bhide SA, Clark C, Miles EA, Miah AB, Newbold K, Tanay M, Adab F, Jefferies SJ, Scrase C, Yap BK, A’Hern RP, Sydenham MA, Emson M, Hall E. Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol. 2011;12(2):127–36. doi:10.1016/S1470-2045(10)70290-4.PubMedCentralPubMedCrossRef Nutting CM, Morden JP, Harrington KJ, Urbano TG, Bhide SA, Clark C, Miles EA, Miah AB, Newbold K, Tanay M, Adab F, Jefferies SJ, Scrase C, Yap BK, A’Hern RP, Sydenham MA, Emson M, Hall E. Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol. 2011;12(2):127–36. doi:10.​1016/​S1470-2045(10)70290-4.PubMedCentralPubMedCrossRef
12.
go back to reference Parliament MB, Scrimger RA, Anderson SG, Kurien EC, Thompson HK, Field GC, Hanson J. Preservation of oral health-related quality of life and salivary flow rates after inverse-planned intensity-modulated radiotherapy (IMRT) for head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2004;58(3):663–73. doi:10.1016/S0360-3016(03)01571-2.PubMedCrossRef Parliament MB, Scrimger RA, Anderson SG, Kurien EC, Thompson HK, Field GC, Hanson J. Preservation of oral health-related quality of life and salivary flow rates after inverse-planned intensity-modulated radiotherapy (IMRT) for head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2004;58(3):663–73. doi:10.​1016/​S0360-3016(03)01571-2.PubMedCrossRef
13.
18.
go back to reference Tong MC, Lo PS, Wong KH, Yeung RM, van Hasselt CA, Eremenco S, Cella D. Development and validation of the functional assessment of cancer therapy nasopharyngeal cancer subscale. Head Neck. 2009;31(6):738–47. doi:10.1002/hed.21023.PubMedCrossRef Tong MC, Lo PS, Wong KH, Yeung RM, van Hasselt CA, Eremenco S, Cella D. Development and validation of the functional assessment of cancer therapy nasopharyngeal cancer subscale. Head Neck. 2009;31(6):738–47. doi:10.​1002/​hed.​21023.PubMedCrossRef
20.
go back to reference Epstein JB, Emerton S, Kolbinson DA, Le ND, Phillips N, Stevenson-Moore P, Osoba D. Quality of life and oral function following radiotherapy for head and neck cancer. Head Neck. 1999;21(1):1–11.PubMedCrossRef Epstein JB, Emerton S, Kolbinson DA, Le ND, Phillips N, Stevenson-Moore P, Osoba D. Quality of life and oral function following radiotherapy for head and neck cancer. Head Neck. 1999;21(1):1–11.PubMedCrossRef
21.
go back to reference Epstein JB, Robertson M, Emerton S, Phillips N, Stevenson-Moore P. Quality of life and oral function in patients treated with radiation therapy for head and neck cancer. Head Neck. 2001;23(5):389–98.PubMedCrossRef Epstein JB, Robertson M, Emerton S, Phillips N, Stevenson-Moore P. Quality of life and oral function in patients treated with radiation therapy for head and neck cancer. Head Neck. 2001;23(5):389–98.PubMedCrossRef
22.
go back to reference Perry A, Morris M, Unsworth C, Duckett S, Skeat J, Dodd K, Taylor N, Reilly K. Therapy outcome measures for allied health practitioners in Australia: the AusTOMs. Int J Qual Health Care. 2004;16(4):285–91. doi:10.1093/intqhc/mzh059.PubMedCrossRef Perry A, Morris M, Unsworth C, Duckett S, Skeat J, Dodd K, Taylor N, Reilly K. Therapy outcome measures for allied health practitioners in Australia: the AusTOMs. Int J Qual Health Care. 2004;16(4):285–91. doi:10.​1093/​intqhc/​mzh059.PubMedCrossRef
23.
go back to reference Langmore SE, Schatz K, Olson N. Endoscopic and videofluoroscopic evaluations of swallowing and aspiration. Ann Otol Rhinol Laryngol. 1991;100(8):678–81.PubMedCrossRef Langmore SE, Schatz K, Olson N. Endoscopic and videofluoroscopic evaluations of swallowing and aspiration. Ann Otol Rhinol Laryngol. 1991;100(8):678–81.PubMedCrossRef
24.
go back to reference Wu CH, Hsiao TY, Ko JY, Hsu MM. Dysphagia after radiotherapy: endoscopic examination of swallowing in patients with nasopharyngeal carcinoma. Ann Otol Rhinol Laryngol. 2000;109(3):320–5.PubMedCrossRef Wu CH, Hsiao TY, Ko JY, Hsu MM. Dysphagia after radiotherapy: endoscopic examination of swallowing in patients with nasopharyngeal carcinoma. Ann Otol Rhinol Laryngol. 2000;109(3):320–5.PubMedCrossRef
25.
go back to reference Pauloski BR, Rademaker AW, Logemann JA, Newman L, MacCracken E, Gaziano J, Stachowiak L. Relationship between swallow motility disorders on videofluorography and oral intake in patients treated for head and neck cancer with radiotherapy with or without chemotherapy. Head Neck. 2006;28(12):1069–76. doi:10.1002/hed.20459.PubMedCrossRef Pauloski BR, Rademaker AW, Logemann JA, Newman L, MacCracken E, Gaziano J, Stachowiak L. Relationship between swallow motility disorders on videofluorography and oral intake in patients treated for head and neck cancer with radiotherapy with or without chemotherapy. Head Neck. 2006;28(12):1069–76. doi:10.​1002/​hed.​20459.PubMedCrossRef
26.
go back to reference Pauloski BR, Rademaker AW, Lazarus C, Boeckxstaens G, Kahrilas PJ, Logemann JA. Relationship between manometric and videofluoroscopic measures of swallow function in healthy adults and patients treated for head and neck cancer with various modalities. Dysphagia. 2009;24(2):196–203. doi:10.1007/s00455-008-9192-x.PubMedCentralPubMedCrossRef Pauloski BR, Rademaker AW, Lazarus C, Boeckxstaens G, Kahrilas PJ, Logemann JA. Relationship between manometric and videofluoroscopic measures of swallow function in healthy adults and patients treated for head and neck cancer with various modalities. Dysphagia. 2009;24(2):196–203. doi:10.​1007/​s00455-008-9192-x.PubMedCentralPubMedCrossRef
27.
go back to reference Eisbruch A, Levendag PC, Feng FY, Teguh D, Lyden T, Schmitz PI, Haxer M, Noever I, Chepeha DB, Heijmen BJ. Can IMRT or brachytherapy reduce dysphagia associated with chemoradiotherapy of head and neck cancer? The Michigan and Rotterdam experiences. Int J Radiat Oncol Biol Phys. 2007;69(2 Suppl):S40–2. doi:10.1016/j.ijrobp.2007.04.083.PubMedCentralPubMedCrossRef Eisbruch A, Levendag PC, Feng FY, Teguh D, Lyden T, Schmitz PI, Haxer M, Noever I, Chepeha DB, Heijmen BJ. Can IMRT or brachytherapy reduce dysphagia associated with chemoradiotherapy of head and neck cancer? The Michigan and Rotterdam experiences. Int J Radiat Oncol Biol Phys. 2007;69(2 Suppl):S40–2. doi:10.​1016/​j.​ijrobp.​2007.​04.​083.PubMedCentralPubMedCrossRef
28.
go back to reference Dirix P, Nuyts S, Vander Poorten V, Delaere P, Van den Bogaert W. The influence of xerostomia after radiotherapy on quality of life: results of a questionnaire in head and neck cancer. Support Care Cancer. 2008;16(2):171–9. doi:10.1007/s00520-007-0300-5.PubMedCrossRef Dirix P, Nuyts S, Vander Poorten V, Delaere P, Van den Bogaert W. The influence of xerostomia after radiotherapy on quality of life: results of a questionnaire in head and neck cancer. Support Care Cancer. 2008;16(2):171–9. doi:10.​1007/​s00520-007-0300-5.PubMedCrossRef
30.
go back to reference Jensen SB, Pedersen AM, Vissink A, Andersen E, Brown CG, Davies AN, Dutilh J, Fulton JS, Jankovic L, Lopes NN, Mello AL, Muniz LV, Murdoch-Kinch CA, Nair RG, Napenas JJ, Nogueira-Rodrigues A, Saunders D, Stirling B, von Bultzingslowen I, Weikel DS, Elting LS, Spijkervet FK, Brennan MT. A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact. Support Care Cancer. 2010;18(8):1061–79. doi:10.1007/s00520-010-0837-6.PubMedCrossRef Jensen SB, Pedersen AM, Vissink A, Andersen E, Brown CG, Davies AN, Dutilh J, Fulton JS, Jankovic L, Lopes NN, Mello AL, Muniz LV, Murdoch-Kinch CA, Nair RG, Napenas JJ, Nogueira-Rodrigues A, Saunders D, Stirling B, von Bultzingslowen I, Weikel DS, Elting LS, Spijkervet FK, Brennan MT. A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact. Support Care Cancer. 2010;18(8):1061–79. doi:10.​1007/​s00520-010-0837-6.PubMedCrossRef
31.
go back to reference Marucci L, Marzi S, Sperduti I, Giovinazzo G, Pinnaro P, Benassi M, Strigari L. Influence of intensity-modulated radiation therapy technique on xerostomia and related quality of life in patients treated with intensity-modulated radiation therapy for nasopharyngeal cancer. Head Neck. 2012;34(3):328–35. doi:10.1002/hed.21736.PubMedCrossRef Marucci L, Marzi S, Sperduti I, Giovinazzo G, Pinnaro P, Benassi M, Strigari L. Influence of intensity-modulated radiation therapy technique on xerostomia and related quality of life in patients treated with intensity-modulated radiation therapy for nasopharyngeal cancer. Head Neck. 2012;34(3):328–35. doi:10.​1002/​hed.​21736.PubMedCrossRef
32.
go back to reference Jensen SB, Pedersen AM, Vissink A, Andersen E, Brown CG, Davies AN, Dutilh J, Fulton JS, Jankovic L, Lopes NN, Mello AL, Muniz LV, Murdoch-Kinch CA, Nair RG, Napenas JJ, Nogueira-Rodrigues A, Saunders D, Stirling B, von Bultzingslowen I, Weikel DS, Elting LS, Spijkervet FK, Brennan MT. A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life. Support Care Cancer. 2010;18(8):1039–60. doi:10.1007/s00520-010-0827-8.PubMedCrossRef Jensen SB, Pedersen AM, Vissink A, Andersen E, Brown CG, Davies AN, Dutilh J, Fulton JS, Jankovic L, Lopes NN, Mello AL, Muniz LV, Murdoch-Kinch CA, Nair RG, Napenas JJ, Nogueira-Rodrigues A, Saunders D, Stirling B, von Bultzingslowen I, Weikel DS, Elting LS, Spijkervet FK, Brennan MT. A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life. Support Care Cancer. 2010;18(8):1039–60. doi:10.​1007/​s00520-010-0827-8.PubMedCrossRef
34.
go back to reference Eisbruch A. Reducing xerostomia by IMRT: what may, and may not be achieved. J Clin Oncol. 2007;25(31):2.CrossRef Eisbruch A. Reducing xerostomia by IMRT: what may, and may not be achieved. J Clin Oncol. 2007;25(31):2.CrossRef
35.
go back to reference Sandow PL, Hejrat-Yazdi M, Heft MW. Taste loss and recovery following radiation therapy. J Dent Res. 2006;85(7):608–11.PubMedCrossRef Sandow PL, Hejrat-Yazdi M, Heft MW. Taste loss and recovery following radiation therapy. J Dent Res. 2006;85(7):608–11.PubMedCrossRef
36.
go back to reference Maes A, Huygh I, Weltens C, Vandevelde G, Delaere P, Evers G, Van den Bogaert W. De Gustibus: time scale of loss and recovery of tastes caused by radiotherapy. Radiother Oncol. 2002;63(2):195–201.PubMedCrossRef Maes A, Huygh I, Weltens C, Vandevelde G, Delaere P, Evers G, Van den Bogaert W. De Gustibus: time scale of loss and recovery of tastes caused by radiotherapy. Radiother Oncol. 2002;63(2):195–201.PubMedCrossRef
37.
go back to reference Bensadoun RJ, Riesenbeck D, Lockhart PB, Elting LS, Spijkervet FK, Brennan MT. A systematic review of trismus induced by cancer therapies in head and neck cancer patients. Support Care Cancer. 2010;18(8):1033–8. doi:10.1007/s00520-010-0847-4.PubMedCrossRef Bensadoun RJ, Riesenbeck D, Lockhart PB, Elting LS, Spijkervet FK, Brennan MT. A systematic review of trismus induced by cancer therapies in head and neck cancer patients. Support Care Cancer. 2010;18(8):1033–8. doi:10.​1007/​s00520-010-0847-4.PubMedCrossRef
38.
go back to reference Cartmill B, Cornwell P, Ward E, Davidson W, Porceddu S. A prospective investigation of swallowing, nutrition, and patient-rated functional impact following altered fractionation radiotherapy with concomitant boost for oropharyngeal cancer. Dysphagia. 2011;. doi:10.1007/s00455-011-9333-5.PubMed Cartmill B, Cornwell P, Ward E, Davidson W, Porceddu S. A prospective investigation of swallowing, nutrition, and patient-rated functional impact following altered fractionation radiotherapy with concomitant boost for oropharyngeal cancer. Dysphagia. 2011;. doi:10.​1007/​s00455-011-9333-5.PubMed
40.
go back to reference Perry A, Skeat J. AusTOMs for speech pathology. Melbourne: La Trobe University; 2004. Perry A, Skeat J. AusTOMs for speech pathology. Melbourne: La Trobe University; 2004.
Metadata
Title
Functional Swallowing Outcomes in Nasopharyngeal Cancer Treated with IMRT at 6 to 42 months Post-Radiotherapy
Authors
Margaret Patterson
Rowena Brain
Ronald Chin
David Veivers
Michael Back
Andrew Wignall
Thomas Eade
Publication date
01-12-2014
Publisher
Springer US
Published in
Dysphagia / Issue 6/2014
Print ISSN: 0179-051X
Electronic ISSN: 1432-0460
DOI
https://doi.org/10.1007/s00455-014-9559-0

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