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Surgical Endoscopy

Published in:

01-07-2017

Functional outcomes after TEM in patients with complete clinical response after neoadjuvant chemoradiotherapy

Authors: Roberto Ghiselli, Monica Ortenzi, Luca Cardinali, Edlira Skrami, Rosaria Gesuita, Mario Guerrieri

Published in: Surgical Endoscopy | Issue 7/2017

Abstract

Background

In patients who exhibit a complete clinical response after radio-chemotherapy for rectal cancer, the standard surgical approach might constitute overtreatment. The aim of this study is to analyse the outcomes of anorectal function and quality of life after transanal endoscopic microsurgery (TEM) in irradiated patients with complete clinical response.

Patients and methods

Between 2007 and 2014, 84 patients who were diagnosed with stage T2–T3–T4 N0 rectal cancer before chemoradiotherapy showed a complete clinical response to neoadjuvant therapy and underwent TEM. All patients were evaluated before and 1 year after TEM using the Cleveland Clinic Florida Fecal Incontinence Score (CCF-FIS) questionnaire to determine the impact of this surgical technique on the degree of faecal continence. To assess the quality of life of patients after surgery, we administered the Fecal Incontinence Quality of Life Scale.

Results

Twenty-three patients exhibited a worse incontinence status after surgical intervention (27.4; 95% CI 18.2–38.2). These patients experienced a median positive absolute variation in the CCF-FIS of four points (95% CI 3.5–4.5; p < 0.001). Female sex and age showed a significant correlation with the worsening of continence status. Scores on the Fecal Incontinence Quality of Life Index Scale did not show a significant difference before and after TEM.

Conclusions

TEM may be an alternative treatment for patients with rectal cancer who exhibit a complete clinical response to neoadjuvant chemoradiotherapy because it offers the possibility to achieve a full thickness excision of the rectal wall. TEM also allows the identification of any residual disease and provides optimal quality of life and functional results.

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Title: Functional outcomes after TEM in patients with complete clinical response after neoadjuvant chemoradiotherapy
Authors: Roberto Ghiselli
Monica Ortenzi
Luca Cardinali
Edlira Skrami
Rosaria Gesuita
Mario Guerrieri
Publication date: 01-07-2017
Publisher: Springer US
Published in: Surgical Endoscopy / Issue 7/2017
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-016-5321-z

At a glance: The STEP trials

Springer Medicine

Functional outcomes after TEM in patients with complete clinical response after neoadjuvant chemoradiotherapy

Abstract

Background

Patients and methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Patients and methods

Results

Conclusions

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