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Experimental & Translational Stroke Medicine

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Open Access 01-12-2010 | Review

Functional assessments in the rodent stroke model

Authors: Krystal L Schaar, Miranda M Brenneman, Sean I Savitz

Published in: Experimental & Translational Stroke Medicine | Issue 1/2010

Abstract

Stroke is a common cause of permanent disability accompanied by devastating impairments for which there is a pressing need for effective treatment. Motor, sensory and cognitive deficits are common following stroke, yet treatment is limited. Along with histological measures, functional outcome in animal models has provided valuable insight to the biological basis and potential rehabilitation efforts of experimental stroke. Developing and using tests that have the ability to identify behavioral deficits is essential to expanding the development of translational therapies. The present aim of this paper is to review many of the current behavioral tests that assess functional outcome after stoke in rodent models. While there is no perfect test, there are many assessments that are sensitive to detecting the array of impairments, from global to modality specific, after stroke.

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Title: Functional assessments in the rodent stroke model
Authors: Krystal L Schaar
Miranda M Brenneman
Sean I Savitz
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Experimental & Translational Stroke Medicine / Issue 1/2010
Electronic ISSN: 2040-7378
DOI: https://doi.org/10.1186/2040-7378-2-13

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Functional assessments in the rodent stroke model

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