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01-04-2017 | Original Article

Functional and neurochemical interactions within the amygdala–medial prefrontal cortex circuit and their relevance to emotional processing

Authors: Stefano Delli Pizzi, Piero Chiacchiaretta, Dante Mantini, Giovanna Bubbico, Antonio Ferretti, Richard A. Edden, Camillo Di Giulio, Marco Onofrj, Laura Bonanni

Published in: Brain Structure and Function | Issue 3/2017

Abstract

The amygdala–medial prefrontal cortex (mPFC) circuit plays a key role in emotional processing. GABA-ergic inhibition within the mPFC has been suggested to play a role in the shaping of amygdala activity. However, the functional and neurochemical interactions within the amygdala–mPFC circuits and their relevance to emotional processing remain unclear. To investigate this circuit, we obtained resting-state functional magnetic resonance imaging (rs-fMRI) and proton MR spectroscopy in 21 healthy subjects to assess the potential relationship between GABA levels within mPFC and the amygdala–mPFC functional connectivity. Trait anxiety was assessed using the State-Trait Anxiety Inventory (STAI-Y2). Partial correlations were used to measure the relationships among the functional connectivity outcomes, mPFC GABA levels and STAI-Y2 scores. Age, educational level and amount of the gray and white matters within ¹H-MRS volume of interest were included as nuisance variables. The rs-fMRI signals of the amygdala and the vmPFC were significantly anti-correlated. This negative functional coupling between the two regions was inversely correlated with the GABA+/tCr level within the mPFC and the STAI-Y2 scores. We suggest a close relationship between mPFC GABA levels and functional interactions within the amygdala–vmPFC circuit, providing new insights in the physiology of emotion.

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Title: Functional and neurochemical interactions within the amygdala–medial prefrontal cortex circuit and their relevance to emotional processing
Authors: Stefano Delli Pizzi
Piero Chiacchiaretta
Dante Mantini
Giovanna Bubbico
Antonio Ferretti
Richard A. Edden
Camillo Di Giulio
Marco Onofrj
Laura Bonanni
Publication date: 01-04-2017
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 3/2017
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-016-1276-z

At a glance: The STEP trials

Springer Medicine

Functional and neurochemical interactions within the amygdala–medial prefrontal cortex circuit and their relevance to emotional processing

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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