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Breast Cancer Research
Published in: Breast Cancer Research 2/2006

01-11-2006 | Poster Presentation

Functional analysis of normal and DCIS modified breast myoepithelial cells

Authors: M Allen, K Mulligan, S Clark, I Hart, JF Marshall, JL Jones

Published in: Breast Cancer Research | Special Issue 2/2006

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Excerpt

Normal breast myoepithelial cells have been shown to exhibit tumour-suppressor activity mediated, in part, by downregulation of MMP expression [1]. DCIS myoepithelial cells have an altered phenotype as demonstrated by a different gene expression profile [2]. We have identified upregulation of α(v)β6 integrin on myoepithelial cells in a subset of DCIS; however, the role of α(v)β6 in this context is not clear. α(v)β6 is not expressed by normal epithelial cells, but is expressed in some cancers where it promotes tumour cell invasion and enhances MMP expression. …
Literature
1.
Jones J, Shaw J, Pringle J, Wlaker R: Primary breast myoepithelial cells exert an invasion-suppressor effect on breast cancer cells via paracrine down-regulation of MMP expression in fibroblasts and tumour cells. J Pathol. 2003, 201: 562-572. 10.1002/path.1483.CrossRefPubMed
2.
Allinen M, Beroukhim R, Cai L, et al: Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell. 2004, 6: 17-32. 10.1016/j.ccr.2004.06.010.CrossRefPubMed
Metadata
Title
Functional analysis of normal and DCIS modified breast myoepithelial cells
Authors
M Allen
K Mulligan
S Clark
I Hart
JF Marshall
JL Jones
Publication date
01-11-2006
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 2/2006
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1569

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