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European Archives of Psychiatry and Clinical Neuroscience

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Open Access 01-06-2012 | Editorial

From pathophysiological aspects towards unravelling the neurobiological background of cognitive deficits

Authors: Peter Falkai, Hans-Jürgen Möller

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 4/2012

Excerpt

Evidence-based medicine is supposed to be a conclusive summary of available empirical knowledge on certain medical issues and as such serving as the basis of guidelines and treatment recommendations. Meant to be self-explaining, the term actually appears to be crucial. It seems inconsistent and inconclusive since recommendations of single countries/institutions are based on different evidence measures—some derive evidence from meta-analyses, whereas others exclusively follow randomised controlled studies. In a philosophical side trip, Möller [1] critically highlights these internationally different measures upon which grading of evidence is levelled and claims a uniform evidence grading. …

Möller H-J (2011) How close is evidence to truth in evidence-based treatment of mental disorders?. Eur Arch Psychiatry Clin Neurosci. doi: 10.1007/s00406-011-0273-8

Helmreich I (2011) Sensitivity to changes during antidepressant treatment: a comparison of unidimensional subscales of the Inventory of depressive symptomatology (IDS-C) and the hamilton depression rating scale (HAMD) in patients with mild major, minor or subsyndromal depression. Eur Arch Psychiatry Clin Neurosci. doi: 10.1007/s00406-011-0263-x

Chiesa A (2011) Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder. Eur Arch Psychiatry Clin Neurosci. doi: 10.1007/s00406-011-0270-y

Kahl KG (2011) Prevalence of the metabolic syndrome in unipolar major Depression. Eur Arch Psychiatry Clin Neurosci. doi: 10.1007/s00406-011-0277-4

Jaddou HY (2011) Depression is associated with low levels of 25-hydroxyvitamin D among Jordanian adults: results from a national population survey. Eur Arch Psychiatry Clin Neurosci. doi: 10.1007/s00406-011-0265-8

Voss B (2011) Cholinergic blockade under working memory demands encountered by increased rehearsal strategies: evidence from fMRI in healthy subjects. Eur Arch Psychiatry Clin Neurosci. doi: 10.1007/s00406-011-0267-6

Likitjaroen Y (2011) Longitudinal changes of fractional anisotropy in Alzheimer’s disease patients treated with galantamine: a 12-month randomized, placebo-controlled, double-blinded study. Eur Arch Psychiatry Clin Neurosci. doi: 10.1007/s00406-011-0234-2

Konrad A (2011) White matter abnormalities and their impact on attentional performance in adult attention-deficit/hyperactivity disorder. Eur Arch Psychiatry Clin Neurosci. doi: 10.1007/s00406-011-0251-1

Title: From pathophysiological aspects towards unravelling the neurobiological background of cognitive deficits
Authors: Peter Falkai
Hans-Jürgen Möller
Publication date: 01-06-2012
Publisher: Springer-Verlag
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 4/2012
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-012-0324-9

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From pathophysiological aspects towards unravelling the neurobiological background of cognitive deficits

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Other articles of this Issue 4/2012

White matter abnormalities and their impact on attentional performance in adult attention-deficit/hyperactivity disorder

Sensitivity to changes during antidepressant treatment: a comparison of unidimensional subscales of the Inventory of Depressive Symptomatology (IDS-C) and the Hamilton Depression Rating Scale (HAMD) in patients with mild major, minor or subsyndromal depression

Cholinergic blockade under working memory demands encountered by increased rehearsal strategies: evidence from fMRI in healthy subjects

Depression is associated with low levels of 25-hydroxyvitamin D among Jordanian adults: results from a national population survey

Longitudinal changes of fractional anisotropy in Alzheimer’s disease patients treated with galantamine: a 12-month randomized, placebo-controlled, double-blinded study

How close is evidence to truth in evidence-based treatment of mental disorders?