From genes to psychoses and back: the role of the 5HT2α-receptor and prepulse inhibition in schizophrenia

go back to reference Anokhin AP, Heath AC, Myers E, Ralano A, Wood S (2003) Genetic influences on prepulse inhibition of startle reflex in humans. Neurosci Lett 353:45–48PubMedCrossRef Anokhin AP, Heath AC, Myers E, Ralano A, Wood S (2003) Genetic influences on prepulse inhibition of startle reflex in humans. Neurosci Lett 353:45–48PubMedCrossRef

go back to reference Cadenhead KS, Swerdlow NR, Shafer KM, Diaz M, Braff DL (2000) Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficits. Am J Psychiatry 157:1660–1668PubMedCrossRef Cadenhead KS, Swerdlow NR, Shafer KM, Diaz M, Braff DL (2000) Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficits. Am J Psychiatry 157:1660–1668PubMedCrossRef

go back to reference Golimbet VE, Lavrushina OM, Kaleda VG, Abramova LI, Lezheiko TV (2007) Supportive evidence for the association between the T102C 5-HTR2A gene polymorphism and schizophrenia: a large-scale case-control and family-based study. Eur Psychiatry 22:167–170PubMedCrossRef Golimbet VE, Lavrushina OM, Kaleda VG, Abramova LI, Lezheiko TV (2007) Supportive evidence for the association between the T102C 5-HTR2A gene polymorphism and schizophrenia: a large-scale case-control and family-based study. Eur Psychiatry 22:167–170PubMedCrossRef

go back to reference Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636–645PubMedCrossRef Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636–645PubMedCrossRef

go back to reference Hurlemann R, Matusch A, Kühn K-U, Berning J, Elmenhorst D, Winz O, Kölsch H, Zilles K, Wagner M, Maier W, Bauer A (2008) 5-HT2A receptor density is decreased in the at-risk mental state. Psychopharmacology 195:579–590PubMedCrossRef Hurlemann R, Matusch A, Kühn K-U, Berning J, Elmenhorst D, Winz O, Kölsch H, Zilles K, Wagner M, Maier W, Bauer A (2008) 5-HT2A receptor density is decreased in the at-risk mental state. Psychopharmacology 195:579–590PubMedCrossRef

go back to reference Kumari V, Soni W, Mathew VM, Sharma T (2000) Prepulse inhibition of the startle response in men with schizophrenia: effects of age of onset of illness, symptoms, and medication. Arch Gen Psychiatry 57:609–614PubMedCrossRef Kumari V, Soni W, Mathew VM, Sharma T (2000) Prepulse inhibition of the startle response in men with schizophrenia: effects of age of onset of illness, symptoms, and medication. Arch Gen Psychiatry 57:609–614PubMedCrossRef

go back to reference Meyer-Lindenberg A, Weinberger DR (2006) Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nature 7:818–827 Meyer-Lindenberg A, Weinberger DR (2006) Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nature 7:818–827

go back to reference O’Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, Hamshere M, Carroll L, Georgieva L, Dwyer S, Holmans P, Marchini JL, Spencer CC, Howie B, Leung HT, Hartmann AM, Möller HJ, Morris DW, Shi Y, Feng G, Hoffmann P, Propping P, Vasilescu C, Maier W, Rietschel M, Zammit S, Schumacher J, Quinn EM, Schulze TG, Williams NM, Giegling I, Iwata N, Ikeda M, Darvasi A, Shifman S, He L, Duan J, Sanders AR, Levinson DF, Gejman PV; Molecular Genetics of Schizophrenia Collaboration, Gejman PV, Sanders AR, Duan J, Levinson DF, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Cloninger CR, Cichon S, Nöthen MM, Gill M, Corvin A, Rujescu D, Kirov G, Owen MJ. (2008) Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 30 Jul 2008. [Epub ahead of print] O’Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, Hamshere M, Carroll L, Georgieva L, Dwyer S, Holmans P, Marchini JL, Spencer CC, Howie B, Leung HT, Hartmann AM, Möller HJ, Morris DW, Shi Y, Feng G, Hoffmann P, Propping P, Vasilescu C, Maier W, Rietschel M, Zammit S, Schumacher J, Quinn EM, Schulze TG, Williams NM, Giegling I, Iwata N, Ikeda M, Darvasi A, Shifman S, He L, Duan J, Sanders AR, Levinson DF, Gejman PV; Molecular Genetics of Schizophrenia Collaboration, Gejman PV, Sanders AR, Duan J, Levinson DF, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Cloninger CR, Cichon S, Nöthen MM, Gill M, Corvin A, Rujescu D, Kirov G, Owen MJ. (2008) Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 30 Jul 2008. [Epub ahead of print]

go back to reference Parsons MJ, D’Souza UM, Arranz M-J, Kerwin RW, Makoff AJ (2004) The -1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity. Biol Psychiatry 56:406–410PubMedCrossRef Parsons MJ, D’Souza UM, Arranz M-J, Kerwin RW, Makoff AJ (2004) The -1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity. Biol Psychiatry 56:406–410PubMedCrossRef

go back to reference Quednow BB, Wagner M, Westheide J, Beckmann K, Bliesener N, Maier W, Kühn K-U (2006) Sensorimotor gating and habituation of the startle response in schizophrenic patients randomly treated with amisulpride or olanzapine. Biol Psychiatry 59:536–545PubMedCrossRef Quednow BB, Wagner M, Westheide J, Beckmann K, Bliesener N, Maier W, Kühn K-U (2006) Sensorimotor gating and habituation of the startle response in schizophrenic patients randomly treated with amisulpride or olanzapine. Biol Psychiatry 59:536–545PubMedCrossRef

go back to reference Quednow BB, Frommann I, Berning J, Kühn KU, Maier W, Wagner M (2008) Impaired sensorimotor gating of the acoustic startle response in the prodrome of schizophrenia. Biol Psychiatry 29 May 2008 [Epub ahead of print] Quednow BB, Frommann I, Berning J, Kühn KU, Maier W, Wagner M (2008) Impaired sensorimotor gating of the acoustic startle response in the prodrome of schizophrenia. Biol Psychiatry 29 May 2008 [Epub ahead of print]

go back to reference Quednow BB, Kühn K-U, Mössner R, Schwab SG, Schuhmacher A, Maier W, Wagner M (2008) Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms. Biol Psychiatry 64:434–437PubMedCrossRef Quednow BB, Kühn K-U, Mössner R, Schwab SG, Schuhmacher A, Maier W, Wagner M (2008) Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms. Biol Psychiatry 64:434–437PubMedCrossRef

go back to reference Quednow BB, Wagner M, Mössner R, Maier W, Kühn K-U (2008) Sensorimotor gating of schizophrenia patients depends on catechol O-methyl-transferase Val158Met polymorphism. Schizophr Bull 17 July 2008 [Epub ahead of print] Quednow BB, Wagner M, Mössner R, Maier W, Kühn K-U (2008) Sensorimotor gating of schizophrenia patients depends on catechol O-methyl-transferase Val158Met polymorphism. Schizophr Bull 17 July 2008 [Epub ahead of print]

go back to reference Sanders AR, Duan J, Levinson DF, Shi J, He D, Hou C, Burrel GJ, Rice JP, Nertney DA, Olincy A, Rozic P, Vinogradov S, Buccola NG (2008) No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: Implications for psychiatric genetics. Am J Psychiatry 165:497–506PubMedCrossRef Sanders AR, Duan J, Levinson DF, Shi J, He D, Hou C, Burrel GJ, Rice JP, Nertney DA, Olincy A, Rozic P, Vinogradov S, Buccola NG (2008) No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: Implications for psychiatric genetics. Am J Psychiatry 165:497–506PubMedCrossRef

go back to reference Serretti A, Drago A, De Ronchi D (2007) HTR2A gene variants and psychiatric disorders: A review of current literature and selection on SNPs for future studies. Curr Med Chem 14:2053–2069PubMedCrossRef Serretti A, Drago A, De Ronchi D (2007) HTR2A gene variants and psychiatric disorders: A review of current literature and selection on SNPs for future studies. Curr Med Chem 14:2053–2069PubMedCrossRef

go back to reference Sullivan PF (2005) The genetics of schizophrenia. PLoS Med 2:e212PubMedCrossRef Sullivan PF (2005) The genetics of schizophrenia. PLoS Med 2:e212PubMedCrossRef

go back to reference Swerdlow NR, Geyer MA (1998) Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia. Schizophr Bull 24:285–301PubMed Swerdlow NR, Geyer MA (1998) Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia. Schizophr Bull 24:285–301PubMed

go back to reference Swerdlow NR, Braff DL, Geyer MA (2000) Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon. Behav Pharmacol 11:185–204PubMed Swerdlow NR, Braff DL, Geyer MA (2000) Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon. Behav Pharmacol 11:185–204PubMed

go back to reference Vollenweider FX, Csomor PA, Knappe B, Geyer MA, Quednow BB (2007) The effects of the preferential 5-HT2A agonist psilocybin on prepulse inhibition of startle in healthy human volunteers depend on interstimulus interval. Neuropsychopharmacology 32:1876–1887PubMedCrossRef Vollenweider FX, Csomor PA, Knappe B, Geyer MA, Quednow BB (2007) The effects of the preferential 5-HT2A agonist psilocybin on prepulse inhibition of startle in healthy human volunteers depend on interstimulus interval. Neuropsychopharmacology 32:1876–1887PubMedCrossRef

go back to reference Williams J, McGuffin P, Nothen M, Owen MJ, Spurlock G (1997) Meta-analysis of association between the 5-HT2a receptor T202C polymorphism and schizophrenia. Lancet 349:1221PubMedCrossRef Williams J, McGuffin P, Nothen M, Owen MJ, Spurlock G (1997) Meta-analysis of association between the 5-HT2a receptor T202C polymorphism and schizophrenia. Lancet 349:1221PubMedCrossRef