Published in:
Open Access
01-12-2017 | Research
Free fatty acids and cardiovascular outcome: a Chinese cohort study on stable coronary artery disease
Authors:
Hui-Wen Zhang, Xi Zhao, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Jing Sun, Geng Liu, Qian Dong, Jian-Jun Li
Published in:
Nutrition & Metabolism
|
Issue 1/2017
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Excerpt
Coronary artery disease (CAD) is the leading cause of death in worldwide because of its adverse clinical outcomes. Free fatty acids (FFAs), also named as non-esterified fatty acids, have attracted considerable attention due to their predictive value in CAD [
1,
2]. FFAs are essential source of energy in human body originating from the adipose tissue, which provide 60%–70% of adenosine triphosphate to the heart cells. Interestingly, previous data have indicated that elevated plasma FFAs level can enhance oxidative stress, subsequently resulting in vascular endothelial dysfunction [
3‐
6] and inflammation [
7,
8]. Meanwhile, FFAs have been shown to influence the metabolize of lipids and glucose, which may aggravate the development of atherosclerosis and insulin resistance [
9,
10]. Therefore, FFAs have been regarded as a risk marker of diabetes, obesity and cardiovascular diseases. …
