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Aesthetic Plastic Surgery

Published in:

01-10-2013 | Original Article

Fractional Carbon Dioxide Laser and Acoustic-Pressure Ultrasound for Transepidermal Delivery of Cosmeceuticals: A Novel Method of Facial Rejuvenation

Authors: M. A. Trelles, F. M. Leclère, P. A. Martínez-Carpio

Published in: Aesthetic Plastic Surgery | Issue 5/2013

Abstract

Background

This study aimed to determine the efficacy and safety of a new facial rejuvenation procedure that combines a fractional carbon dioxide (CO₂) laser, an ultrasound emitter, and a cosmeceutical preparation to be applied intraoperatively.

Methods

A split-face, double-blind randomized prospective study of 14 patients was designed, in which one half of the face was treated with a fractional CO₂ laser, with the other half receiving the same laser and acoustic pressure ultrasound for transepidermal delivery of cosmeceuticals. Two semiquantitative scales and two visual analog scales were completed to evaluate the efficacy of each treatment. The results were assessed on the basis of photographs taken before treatment and then after 1, 2, and 6 months afterward. Potential adverse effects and complications were recorded.

Results

Both treatments achieved significant improvements in all parameters evaluated (p < 0.001). The combined ultrasound and cosmeceutical treatment had better scores for reduced fine lines and wrinkles as well as for overall facial aging at 6 months (p < 0.01), with nearly 80 % overall improvement in facial aging. The treatment was well tolerated, and no unexpected adverse effects were observed. The majority of the patients (86 %) stated that they were satisfied or very satisfied with their results.

Conclusion

One session of fractional ablative CO₂ laser and acoustic pressure ultrasound technology for transepidermal delivery of cosmeceuticals is an effective method for treating facial rejuvenation.

Level of Evidence III

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Title: Fractional Carbon Dioxide Laser and Acoustic-Pressure Ultrasound for Transepidermal Delivery of Cosmeceuticals: A Novel Method of Facial Rejuvenation
Authors: M. A. Trelles
F. M. Leclère
P. A. Martínez-Carpio
Publication date: 01-10-2013
Publisher: Springer US
Published in: Aesthetic Plastic Surgery / Issue 5/2013
Print ISSN: 0364-216X
Electronic ISSN: 1432-5241
DOI: https://doi.org/10.1007/s00266-013-0176-3

At a glance: The STEP trials

Springer Medicine

Fractional Carbon Dioxide Laser and Acoustic-Pressure Ultrasound for Transepidermal Delivery of Cosmeceuticals: A Novel Method of Facial Rejuvenation

Abstract

Background

Methods

Results

Conclusion

Level of Evidence III

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Level of Evidence III

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