Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 1/2019

01-01-2019 | Retinal Disorders

Foveal microvascular anomalies on optical coherence tomography angiography and the correlation with foveal thickness and visual acuity in retinopathy of prematurity

Authors: Yen-Chih Chen, Yan-Ting Chen, San-Ni Chen

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 1/2019

Login to get access

Abstract

Purpose

To assess foveal microvascular structure and the correlation between foveal retinal thickness and best corrected visual acuity (BCVA) in children with retinopathy of prematurity (ROP).

Methods

This is a retrospective case-control study. A total 42 eyes in 23 patients with history of anti-vascular endothelial factor (VEGF) agent treatment and 51 eyes of 27 healthy age-matched subjects as the control group were analyzed. Foveal avascular zone (FAZ) and foveal vessel density (VD) were measured by optical coherence tomography angiography (OCT-A). Foveal thickness was measured by cross-sectional OCT. Correlations between FAZ area, foveal VD, foveal thickness, BCVA, gestational age (GA), and birth body weight (BBW) were performed.

Results

ROP children had a significantly smaller FAZ area and higher foveal VD, and the foveal thickness was significantly higher as compared to controls (all P < 0.0001). We noted a significant negative correlation between FAZ area and foveal thickness. In addition, a significant positive correlation between foveal VD and foveal thickness was identified. With regard to prematurity status, gestational age and birth body weight were both significantly correlated with FAZ area, foveal VD, and fovea inner retinal thickness. Multivariable analysis showed that thicker inner retinal thickness and higher superficial vascular density were associated with suboptimal visual acuity.

Conclusion

By using OCT-A, we identified significant foveal microvascular anomalies in ROP children. The correlation between the microvascular anomalies, central foveal thickness, and suboptimal visual acuity was also noted. Because of the retrospective nature, more studies are necessary to further establish the relationship.
Literature
1.
Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, Ferrara N (1993) Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362(6423):841–844CrossRef
2.
Pierce EA, Avery RL, Foley ED, Aiello LP, Smith LE (1995) Vascular endothelial growthfactor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci U S A 92(3):905–909CrossRefPubMedPubMedCentral
3.
Hartnett ME, Penn JS (2013) Mechanisms and management of retinopathy of prematurity. N Engl J Med 368(12):1162–1163PubMed
4.
Mintz-Hittner HA, Prager TC, Kretzer FL (1992) Visual acuity correlates with severity ofretinopathy of prematurity in untreated infants weighing 750 g or less at birth. Arch Ophthalmol 110(8):1087–1091CrossRefPubMed
5.
Mintz-Hittner HA, Knight-Nanan DM, Satriano DR, Kretzer FL (1999) A small foveal avascular zone may be an historic mark of prematurity. Ophthalmology 106(7):1409–1413CrossRefPubMed
6.
Ecsedy M, Szamosi A, Karkó C, Zubovics L, Varsányi B, Németh J, Récsán Z (2007) A comparison of macular structure imaged by optical coherence tomography in preterm and full-term children. Invest Ophthalmol Vis Sci 48:5207–5211CrossRefPubMed
7.
Vinekar A, Avadhani K, Sivakumar M, Mahendradas P, Kurian M, Braganza S, Shetty R, Shetty BK (2011) Understanding clinically undetected macular changes in early retinopathy of prematurity on spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci 52:5183–5188CrossRefPubMed
8.
Vinekar A, Mangalesh S, Jayadev C, Maldonado RS, Bauer N, Toth CA (2015) Retinal imaging of infants on spectral domain optical coherence tomography Biomed Res Int 782420
9.
Jia Y, Tan O, Tokayer J, Potsaid B, Wang Y, Liu JJ, Kraus MF, Subhash H, Fujimoto JG, Hornegger J, Huang D (2012) Split-spectrum amplitude-decorrelation angiographywith optical coherence tomography. Opt Express 20(4):4710–4725CrossRefPubMedPubMedCentral
10.
Spaide RF, Klancnik JM Jr, Cooney MJ (2015) Retinal vascular layers imaged byfluorescein angiography and optical coherence tomography angiography. JAMA Ophthalmol 133(1):45–50CrossRefPubMed
11.
Campbell JP, Nudleman E, Yang J, Tan O, Chan RVP, Chiang MF, Huang D, Liu G (2017) Handheld optical coherence tomography angiography and ultra-wide-field optical coherence tomography in retinopathy of prematurity. JAMA Ophthalmol 135(9):977–981CrossRefPubMedPubMedCentral
12.
Vinekar A, Chidambara L, Jayadev C, Sivakumar M, Webers CA, Shetty B (2016) Monitoring neovascularization in aggressive posterior retinopathy of prematurity using optical coherence tomography angiography. J AAPOS 20(3):271–274CrossRefPubMed
13.
Falavarjani KG, Iafe NA, Velez FG, Schwartz SD, Sadda SR, Sarraf D, Tsui I (2017) Optical coherence tomography angiography of the fovea in children born preterm. Retina 37(12):2289–2294CrossRefPubMed
14.
Nonobe N, Kaneko H,Ito Y,Takayama K,Kataoka K,Tsunekawa T,Matsuura T,Suzumura A,Shimizu H,Terasaki H (2017) Optical coherence tomographyangiography of the foveal avascular zone in children with a history of treatment-requiring retinopathy of prematurity. Retina DOI: https://​doi.​org/​10.​1097/​IAE.​0000000000001937​
15.
Kraus MF, Potsaid B, Mayer MA, Bock R, Baumann B, Liu JJ, Hornegger J, Fujimoto JG (2012) Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns. Biomed Opt Express 3(6):1182–1199CrossRefPubMedPubMedCentral
16.
Provis JM (2001) Development of the primate retinal vasculature. Prog Retin Eye Res 20(6):799–821CrossRefPubMed
17.
Engerman RL (1976) Development of the macular circulation. Invest Ophthalmol Vis Sci 15(10):835–840
18.
Springer AD, Hendrickson AE (2005) Development of the primate area of high acuity, 3: temporal relationships between pit formation, retinal elongation and cone packing. Vis Neurosci 22(2):171–185CrossRefPubMed
19.
Böhm MR, Hodes F, Brockhaus K, Hummel S, Schlatt S, Melkonyan H, Thanos S (2016) Is Angiostatin involved in physiological foveal Avascularity? Invest Ophthalmol Vis Sci 57(11):4536–4552CrossRefPubMed
20.
Springer AD, Hendrickson AE (2004) Development of the primate area of high acuity. 1. Use of finite element analysis models to identify mechanical variables affecting pit formation. Vis Neurosci 21:53–62CrossRefPubMed
21.
Wu WC, Lin RI, Shih CP, Wang NK, Chen YP, Chao AN, Chen KJ, Chen TL, Hwang YS, Lai CC, Huang CY, Tsai S (2012) Visual acuity, optical components, and macular abnormalities in patients with a history of retinopathy of prematurity. Ophthalmology 119(9):1907–1916CrossRefPubMed
22.
Gursoy H, Bilgec MD, Erol N, Basmak H, Colak E (2016) The macular findings on spectral-domain optical coherence tomography in premature infants with or without retinopathy of prematurity. Int Ophthalmol 36(4):591–600CrossRefPubMed
23.
Dubis AM, Subramaniam CD, Godara P, Carroll J, Costakos DM (2013) Subclinical macular findings in infants screened for retinopathy of prematurity with spectral-domain optical coherence tomography. Ophthalmology 120(8):1665–1671CrossRefPubMedPubMedCentral
24.
Wang J, Spencer R, Leffler JN, Birch EE (2012) Critical period for foveal fine structure in children with regressed retinopathy of prematurity. Retina 32(2):330–339CrossRefPubMed
25.
Pueyo V, González I, Altemir I, Pérez T, Gómez G, Prieto E, Oros D (2015) Microstructural changes in the retina related to prematurity. Am J Ophthalmol 159(4):797–802CrossRefPubMed
26.
Hammer DX, Iftimia NV, Ferguson RD, Bigelow CE, Ustun TE, Barnaby AM, Fulton AB (2008) Foveal fine structure in retinopathy of prematurity: an adaptive optics Fourier domain optical coherence tomography study. Invest Ophthalmol Vis Sci 49(5):2061–2070CrossRefPubMedPubMedCentral
27.
Yanni SE, Wang J, Chan M, Carroll J, Farsiu S, Leffler JN, Spencer R, Birch EE (2012) Foveal avascular zone and foveal pit formation after preterm birth. Br J Ophthalmol 96(7):961–966CrossRefPubMed
28.
Villegas VM, Capó H, Cavuoto K, McKeown CA, Berrocal AM (2014) Foveal structure-function correlation in children with history of retinopathy of prematurity. Am J Ophthalmol 158(3):508–512CrossRefPubMed
29.
Stoica F, Chirita-Emandi A, Andreescu N, Stanciu A, Zimbru CG, Puiu M (2017) Clinical relevance of retinal structure in children with laser-treated retinopathy of prematurity versus controls - using optical coherence tomography. Acta Ophthalmol. https://​doi.​org/​10.​1111/​aos.​13536
30.
Fieß A, Janz J, Schuster AK, Kölb-Keerl R, Knuf M, Kirchhof B, Muether PS, Bauer J (2017) Macular morphology in former preterm and full-term infants aged 4 to 10 years. Graefes Arch Clin Exp Ophthalmol 255:1433–1442CrossRefPubMed
31.
Shao Z, Dorfman AL, Seshadri S (2011) Choroidal involution is a key component of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci 52:6238–6248CrossRefPubMed
32.
33.
Magrath GN, Say EAT, Sioufi K, Ferenczy S, Samara WA, Shields CL (2017) Variability in foveal avascular zone and capillary density using optical coherence tomography angiography machines in healthy eyes. Retina 37(11):2102–2111CrossRefPubMed
34.
Carpineto P, Mastropasqua R, Marchini G, Toto L, Di Nicola M, Di Antonio L (2016) Reproducibility and repeatability of foveal avascular zone measurements in healthy subjects by optical coherence tomography angiography. Br J Ophthalmol 100(5):671–676CrossRefPubMed
35.
Chiang MF, Jiang L, Gelman R, Du Y (2007) Inter expert agreement of plus disease diagnosis in retinopathy of prematurity. Arch Ophthalmol 125:875–880CrossRefPubMed
36.
Wallace D, Quinn G, Freedman S, Chiang MF (2008) Agreement among pediatric ophthalmologists in diagnosing plus and pre-plus disease in retinopathy of prematurity. J AAPOS 12:352–356CrossRefPubMedPubMedCentral
37.
Koreen S, Gelman R, Martinez-Perez ME, Jiang L, Berrocal AM, Hess DJ, Flynn JT, Chiang MF (2007) Evaluation of a computer-based system for plus disease diagnosis in retinopathy of prematurity. Ophthalmology 114:e59–e67CrossRefPubMed
38.
Campbell JP, Ryan MC, LoreE TP, Ostmo S, Jonas K, Chan RVP, Chiang M (2016) Diagnostic discrepancies in retinopathy of prematurity classification. Ophthalmology 123:1795–1801CrossRefPubMedPubMedCentral
Metadata
Title
Foveal microvascular anomalies on optical coherence tomography angiography and the correlation with foveal thickness and visual acuity in retinopathy of prematurity
Authors
Yen-Chih Chen
Yan-Ting Chen
San-Ni Chen
Publication date
01-01-2019
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 1/2019
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-018-4162-y

Other articles of this Issue 1/2019

Graefe's Archive for Clinical and Experimental Ophthalmology 1/2019 Go to the issue

Letter to the Editor

ADenoVirus Initiative Study in Epidemiology (ADVISE)—results of a multicenter epidemiology study in Germany

Retinal Disorders

Choriocapillaris flow features and choroidal vasculature in the fellow eyes of patients with acute central serous chorioretinopathy

Basic Science

Activation of the sweet taste receptor T1R3 by sucralose attenuates VEGF-induced vasculogenesis in a cell model of the retinal microvascular endothelium

Glaucoma

Efficacy of glaucoma drainage devices in uveitic glaucoma and a meta-analysis of the literature

Letter to the Editor

Choroidal thickness changes stratified by outcome in real-world treatment of diabetic macular edema

Inflammatory Disorders

Relevance of erythrocyte sedimentation rate and C-reactive protein in patients with active uveitis