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01-03-2010 | Poster presentation

Four-day sedation using sevoflurane: fluoride and renal function

Authors: K Wagner, A Becker, T Meier, H Kehnscherper, HM Benad

Published in: Critical Care | Special Issue 1/2010

Excerpt

Volatile anesthetics for sedation in the ICU are currently undergoing a revival, mainly due to the recent availability of a novel delivery system, the anesthetic conserving device (ACD). Cytochrome P450 metabolic degradation of isoflurane and sevoflurane leads to the generation of inorganic fluoride and hexafluoro isopropanol. Historically, data derived from methoxyfluorane defined a fluoride nephrotoxicity threshold of 50 μmol/l. Therefore, we investigated the feasibility and safety, focusing on kidney function, of 4-day sevoflurane-ACD sedation. …

Roehm , et al.: Anesth Analg. 2009, 108: 1848-5184. 10.1213/ane.0b013e3181a1988bCrossRef

Title: Four-day sedation using sevoflurane: fluoride and renal function
Authors: K Wagner
A Becker
T Meier
H Kehnscherper
HM Benad
Publication date: 01-03-2010
Publisher: BioMed Central
Published in: Critical Care / Issue Special Issue 1/2010
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc8715

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Four-day sedation using sevoflurane: fluoride and renal function

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Keynote webinar | Spotlight on medication adherence

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