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01-01-2015 | Correspondence

Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts

Authors: Manuel Schweighauser, Mehtap Bacioglu, Sarah K. Fritschi, Derya R. Shimshek, Philipp J. Kahle, Yvonne S. Eisele, Mathias Jucker

Published in: Acta Neuropathologica | Issue 1/2015

Excerpt

Compelling evidence suggests that in a variety of neurodegenerative diseases the induction and spreading of proteinaceous lesions involve a prion-like seeding mechanism [5]. Experimentally and for Alzheimer’s disease (AD), it has been shown that cerebral β-amyloidosis can be instigated in susceptible hosts [i.e., young amyloid precursor protein (APP) transgenic (tg) mice] by the intracerebral injections of diluted extracts from β-amyloid-laden brains of aged APP tg mice or AD patients. The β-amyloid-inducing agent in the inoculate is an aggregated form of the amyloid-β peptide (Aβ) [8]. Remarkably, we recently reported that extracts of formaldehyde-fixed brains of aged APP tg mice or AD patients also induces cerebral β-amyloidosis [2]. Thus, Aβ seeds share one of the most remarkable attributes of prions, namely the resistance to inactivation by formaldehyde. …

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Title: Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts
Authors: Manuel Schweighauser
Mehtap Bacioglu
Sarah K. Fritschi
Derya R. Shimshek
Philipp J. Kahle
Yvonne S. Eisele
Mathias Jucker
Publication date: 01-01-2015
Publisher: Springer Berlin Heidelberg
Published in: Acta Neuropathologica / Issue 1/2015
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-014-1360-5

At a glance: The STEP trials

Springer Medicine

Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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