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Open Access 14-05-2024 | EM - REVIEW

Food contamination and cardiovascular disease: a narrative review

Authors: Gerardo Mancuso, Francesco Violi, Cristina Nocella

Published in: Internal and Emergency Medicine

Abstract

Cardiovascular disease is a significant cause of morbidity and mortality among non-communicable diseases worldwide. Evidence shows that a healthy dietary pattern positively influences many risk factors of cardiometabolic health, stroke, and heart disease, supported by the effectiveness of healthy diet and lifestyles for the prevention of CVD. High quality and safety of foods are prerequisites to ensuring food security and beneficial effects. Contaminants can be present in foods mainly because of contamination from environmental sources (water, air, or soil pollution), or artificially introduced by the human. Moreover, the cross-contamination or formation during food processing, food packaging, presence or contamination by natural toxins, or use of unapproved food additives and adulterants. Numerous studies reported the association between food contaminants and cardiovascular risk by demonstrating that (1) the cross-contamination or artificial sweeteners, additives, and adulterants in food processing can be the cause of the risk for major adverse cardiovascular events and (2) environmental factors, such as heavy metals and chemical products can be also significant contributors to food contamination with a negative impact on cardiovascular systems. Furthermore, oxidative stress can be a common mechanism that mediates food contamination-associated CVDs as substantiated by studies showing impaired oxidative stress biomarkers after exposure to food contaminants.This narrative review summarizes the data suggesting how food contaminants may elicit artery injury and proposing oxidative stress as a mediator of cardiovascular damage.

Vaduganathan M, Mensah GA, Turco JV, Fuster V, Roth GA (2022) The global burden of cardiovascular diseases and risk: a compass for future health. J Am Coll Cardiol 80(25):2361–2371. https://doi.org/10.1016/j.jacc.2022.11.005CrossRefPubMed

Mozaffarian D (2016) Dietary and policy priorities for cardiovascular disease, diabetes, and obesity: a omprehensive review. Circulation 133(2):187–225. https://doi.org/10.1161/CIRCULATIONAHA.115.018585.PubMedPMID:26746178;PubMedCentralPMCID:PMCPMC4814348CrossRefPubMedPubMedCentral

Fukuda K (2015) Food safety in a globalized world. Bull World Health Organ 93(4):212. https://doi.org/10.2471/BLT.15.154831CrossRefPubMedPubMedCentral

Monteiro CA, Cannon G, Levy RB, Moubarac JC, Louzada ML, Rauber F et al (2019) Ultra-processed foods: what they are and how to identify them. Public Health Nutr 22(5):936–941. https://doi.org/10.1017/S1368980018003762CrossRefPubMedPubMedCentral

Zhong GC, Gu HT, Peng Y, Wang K, Wu YQ, Hu TY et al (2021) Association of ultra-processed food consumption with cardiovascular mortality in the US population: long-term results from a large prospective multicenter study. Int J Behav Nutr Phys Act 18(1):21. https://doi.org/10.1186/s12966-021-01081-3CrossRefPubMedPubMedCentral

Guo L, Li F, Tang G, Yang B, Yu N, Guo F et al (2023) Association of ultra-processed foods consumption with risk of cardio-cerebrovascular disease: A systematic review and meta-analysis of cohort studies. Nutr Metab Cardiovasc Dis 33(11):2076–2088. https://doi.org/10.1016/j.numecd.2023.07.005CrossRefPubMed

Zhang X, Li X, Liu L, Hong F, Zhao H, Chen L et al (2021) Dose-response association between sugar- and artificially sweetened beverage consumption and the risk of metabolic syndrome: a meta-analysis of population-based epidemiological studies. Public Health Nutr 24(12):3892–3904. https://doi.org/10.1017/S1368980020003614CrossRefPubMed

Ruiz-Ojeda FJ, Plaza-Díaz J, Sáez-Lara MJ, Gil A (2019) Effects of sweeteners on the gut microbiota: a review of experimental studies and clinical trials. Adv Nutr 10:S31-s48. https://doi.org/10.1093/advances/nmy037CrossRefPubMedPubMedCentral

Jang W, Jeoung NH, Cho KH (2011) Modified apolipoprotein (apo) A-I by artificial sweetener causes severe premature cellular senescence and atherosclerosis with impairment of functional and structural properties of apoA-I in lipid-free and lipid-bound state. Mol Cells 31(5):461–470. https://doi.org/10.1007/s10059-011-1009-3CrossRefPubMedPubMedCentral

10.

Guru SK, Li Y, Savinova OV, Zhang Y (2022) Long-term consumption of artificial sweeteners does not affect cardiovascular health and survival in rats. PeerJ. https://doi.org/10.7717/peerj.13071CrossRefPubMedPubMedCentral

11.

Debras C, Chazelas E, Sellem L, Porcher R, Druesne-Pecollo N, Esseddik Y et al (2022) Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Sante cohort. BMJ. https://doi.org/10.1136/bmj-2022-071204CrossRefPubMedPubMedCentral

12.

Witkowski M, Nemet I, Alamri H, Wilcox J, Gupta N, Nimer N et al (2023) The artificial sweetener erythritol and cardiovascular event risk. Nat Med 29(3):710–718. https://doi.org/10.1038/s41591-023-02223-9CrossRefPubMedPubMedCentral

13.

Chen Z, Hu Y, Hu FB, Manson JE, Rimm EB, Doria A et al (2023) dietary glutamine and glutamate in relation to cardiovascular disease incidence and mortality in the united States Men and women with diabetes mellitus. J Nutr. https://doi.org/10.1016/j.tjnut.2023.08.031CrossRefPubMedPubMedCentral

14.

Singh K, Ahluwalia P (2012) Effect of monosodium glutamate on lipid peroxidation and certain antioxidant enzymes in cardiac tissue of alcoholic adult male mice. J Cardiovasc Dis Res 3(1):12–18. https://doi.org/10.4103/0975-3583.91595.PubMedPMID:22346139;PubMedCentralPMCID:PMCPMC3271674CrossRefPubMedPubMedCentral

15.

Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, Ley RE et al (2015) Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 519(7541):92–96. https://doi.org/10.1038/nature14232CrossRefPubMedPubMedCentral

16.

Sellem L, Srour B, Javaux G, Chazelas E, Chassaing B, Viennois E et al (2023) Food additive emulsifiers and risk of cardiovascular disease in the nutrinet-sante cohort: prospective cohort study. BMJ. https://doi.org/10.1136/bmj-2023-076058CrossRefPubMedPubMedCentral

17.

Zhang Q, Bai Y, Yang Z, Tian J, Meng Z (2015) The molecular mechanisms of sodium metabisulfite on the expression of K ATP and L-Ca2+ channels in rat hearts. Regul Toxicol Pharmacol 72(3):440–446. https://doi.org/10.1016/j.yrtph.2015.05.021CrossRefPubMed

18.

Cox S, Sandall A, Smith L, Rossi M, Whelan K (2021) Food additive emulsifiers: a review of their role in foods, legislation and classifications, presence in food supply, dietary exposure, and safety assessment. Nutr Rev 79(6):726–741. https://doi.org/10.1093/nutrit/nuaa038. (PubMed PMID: 32626902)CrossRefPubMed

19.

Sarion C, Codina GG, Dabija A (2021) Acrylamide in bakery Products: a review on health risks, legal regulations and strategies to reduce Its formation. Int J Environ Res Public Health 18(8):726–742. https://doi.org/10.3390/ijerph18084332CrossRef

20.

Huang M, Jiao J, Wang J, Chen X, Zhang Y. Associations of hemoglobin biomarker levels of acrylamide and all-cause and cardiovascular disease mortality among U.S. adults: National Health and Nutrition Examination Survey 2003-2006. Environ Pollut. 2018;238:852-8. Epub 20180410.1016/j.envpol.2018.03.109

21.

Martinez Steele E, Buckley JP, Monteiro CA (2023) Ultra-processed food consumption and exposure to acrylamide in a nationally representative sample of the US population aged 6 years and older. Prev Med. https://doi.org/10.1016/j.ypmed.2023.107598CrossRefPubMed

22.

Naruszewicz M, Daniewski M, Nowicka G, Kozlowska-Wojciechowska M (2003) Trans-unsaturated fatty acids and acrylamide in food as potential atherosclerosis progression factors. Based on own studies Acta Microbiol Pol. 52:75–81PubMed

23.

Zhang Y, Huang M, Zhuang P, Jiao J, Chen X, Wang J et al (2018) Exposure to acrylamide and the risk of cardiovascular diseases in the national health and nutrition examination survey 2003–2006. Environ Int 117:154–163. https://doi.org/10.1016/j.envint.2018.04.047CrossRefPubMed

24.

DeJarnett N, Conklin DJ, Riggs DW, Myers JA, O’Toole TE, Hamzeh I et al (2014) Acrolein exposure is associated with increased cardiovascular disease risk J Am Heart Assoc 3(4):154–163. https://doi.org/10.1161/JAHA.114.000934CrossRef

25.

Ranciere F, Lyons JG, Loh VH, Botton J, Galloway T, Wang T et al (2015) Bisphenol A and the risk of cardiometabolic disorders: a systematic review with meta-analysis of the epidemiological evidence. Environ Health 14:46. https://doi.org/10.1186/s12940-015-0036-5CrossRefPubMedPubMedCentral

26.

Juul F, Vaidean G, Parekh N (2021) Ultra-processed foods and cardiovascular diseases: potential mechanisms of action. Adv Nutr 12(5):1673–1680. https://doi.org/10.1093/advances/nmab049.PubMedPMID:33942057;PubMedCentralPMCID:PMCPMC8483964CrossRefPubMedPubMedCentral

27.

Song P, Wu L, Guan W (2015) Dietary nitrates, nitrites, and nitrosamines intake and the risk of gastric Ccncer: a meta-analysis. Nutrients 7(12):9872–9895. https://doi.org/10.3390/nu7125505CrossRefPubMedPubMedCentral

28.

Weitzberg E, Lundberg JO (2013) Novel aspects of dietary ntrate and human health. Annu Rev Nutr 33(1):129–159. https://doi.org/10.1146/annurev-nutr-071812-161159. (PubMed PMID: 23642194)CrossRefPubMed

29.

Ashworth A, Mitchell K, Blackwell JR, Vanhatalo A, Jones AM (2015) High-nitrate vegetable diet increases plasma nitrate and nitrite concentrations and reduces blood pressure in healthy women. Public Health Nutr 18(14):2669–2678. https://doi.org/10.1017/S1368980015000038CrossRefPubMedPubMedCentral

30.

Berry MJ, Justus NW, Hauser JI, Case AH, Helms CC, Basu S et al (2015) Dietary nitrate supplementation improves exercise performance and decreases blood pressure in COPD patients. Nitric Oxide 48:22–30. https://doi.org/10.1016/j.niox.2014.10.007CrossRefPubMed

31.

Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A (2015) Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension 65(2):320–327. https://doi.org/10.1161/HYPERTENSIONAHA.114.04675CrossRefPubMed

32.

Sheweita SA, El-Bendery HA, Mostafa MH (2014) Novel study on N-nitrosamines as risk factors of cardiovascular diseases. Biomed Res Int. https://doi.org/10.1155/2014/817019CrossRefPubMedPubMedCentral

33.

Lee BJ, Kim B, Lee K (2014) Air pollution exposure and cardiovascular disease. Toxicol Res 30(2):71–75. https://doi.org/10.5487/TR.2014.30.2.071.PubMedPMID:25071915;PubMedCentralPMCID:PMCPMC4112067CrossRefPubMedPubMedCentral

34.

Lamas GA, Bhatnagar A, Jones MR, Mann KK, Nasir K, Tellez-Plaza M et al (2023) Contaminant Metals as Cardiovascular Risk Factors: A Scientific Statement From the American Heart Association. J Am Heart Assoc. https://doi.org/10.1161/JAHA.123.029852CrossRefPubMedPubMedCentral

35.

Jarup L (2003) Hazards of heavy metal contamination. Br Med Bull 68:167–182. https://doi.org/10.1093/bmb/ldg032. (PubMed PMID: 14757716)CrossRefPubMed

36.

Moon K, Guallar E, Navas-Acien A (2012) Arsenic exposure and cardiovascular disease: an updated systematic review. Curr Atheroscler Rep 14(6):542–555. https://doi.org/10.1007/s11883-012-0280-x.PubMedPMID:22968315;PubMedCentralPMCID:PMCPMC3483370CrossRefPubMedPubMedCentral

37.

Navas-Acien A, Sharrett AR, Silbergeld EK, Schwartz BS, Nachman KE, Burke TA et al (2005) Arsenic exposure and cardiovascular disease: a systematic review of the epidemiologic evidence. Am J Epidemiol 162(11):1037–1049. https://doi.org/10.1093/aje/kwi330CrossRefPubMed

38.

Wang CH, Hsiao CK, Chen CL, Hsu LI, Chiou HY, Chen SY et al (2007) A review of the epidemiologic literature on the role of environmental arsenic exposure and cardiovascular diseases. Toxicol Appl Pharmacol 222(3):315–326. https://doi.org/10.1016/j.taap.2006.12.022CrossRefPubMed

39.

Gump BB, Heffernan K, Brann LS, Hill DT, Labrie-Cleary C, Jandev V et al (2023) Exposure to arsenic and subclinical cardiovascular disease in 9- to 11-year-old children, syracuse, New York. JAMA Netw Open. https://doi.org/10.1001/jamanetworkopen.2023.21379CrossRefPubMedPubMedCentral

40.

Neisi A, Farhadi M, Cheraghian B, Dargahi A, Ahmadi M, Takdastan A et al (2024) Consumption of foods contaminated with heavy metals and their association with cardiovascular disease (CVD) using GAM software (cohort study). Heliyon. https://doi.org/10.1016/j.heliyon.2024.e24517CrossRefPubMedPubMedCentral

41.

Khaleda L, Begum SK, Apu MAR, Chowdhury RH, Alam MJ, Datta A et al (2024) Arsenic-induced cardiovascular diseases and their correlation with mitochondrial DNA copy number, deletion, and telomere length in bangladeshi population. Cardiovasc Toxicol 24(1):27–40. https://doi.org/10.1007/s12012-023-09812-7CrossRefPubMed

42.

Sobenin IA, Zhelankin AV, Mitrofanov KY, Sinyov VV, Sazonova MA, Postnov AY et al (2015) Mutations of mitochondrial DNA in atherosclerosis and atherosclerosis-related diseases. Curr Pharm Des 21(9):1158–1163. https://doi.org/10.2174/1381612820666141013133000. (PubMed PMID: 25312735)CrossRefPubMed

43.

Yin H, Pickering JG (2023) Telomere length: implications for atherogenesis. Curr Atheroscler Rep 25(3):95–103. https://doi.org/10.1007/s11883-023-01082-6CrossRefPubMedPubMedCentral

44.

Yan YZ, Hu YH, Guo H, Lin KQ (2022) Burden of cardiovascular disease attributable to dietary lead exposure in adolescents and adults in China. Sci Total Environ. https://doi.org/10.1016/j.scitotenv.2022.156315CrossRefPubMedPubMedCentral

45.

Sanders T, Liu Y, Buchner V, Tchounwou PB (2009) Neurotoxic effects and biomarkers of lead exposure: a review. Rev Environ Health 24(1):15–45. https://doi.org/10.1515/reveh.2009.24.1.15.PubMedPMID:19476290;PubMedCentralPMCID:PMCPMC2858639CrossRefPubMedPubMedCentral

46.

Prozialeck WC, Edwards JR (2012) Mechanisms of cadmium-induced proximal tubule injury: new insights with implications for biomonitoring and therapeutic interventions. J Pharmacol Exp Ther 343(1):2–12. https://doi.org/10.1124/jpet.110.166769CrossRefPubMedPubMedCentral

47.

Akesson A, Bjellerup P, Lundh T, Lidfeldt J, Nerbrand C, Samsioe G et al (2006) Cadmium-induced effects on bone in a population-based study of women. Environ Health Perspect 114(6):830–834. https://doi.org/10.1289/ehp.8763.PubMedPMID:16759980;PubMedCentralPMCID:PMCPMC1480481CrossRefPubMedPubMedCentral

48.

Fagerberg B, Barregard L (2021) Review of cadmium exposure and smoking-independent effects on atherosclerotic cardiovascular disease in the general population. J Intern Med 290(6):1153–1179. https://doi.org/10.1111/joim.13350CrossRefPubMed

49.

van der Voet GB, Todorov TI, Centeno JA, Jonas W, Ives J, Mullick FG (2007) Metals and health: a clinical toxicological perspective on tungsten and review of the literature. Mil Med 172(9):1002–1005. https://doi.org/10.7205/milmed.172.9.1002. (PubMed PMID: 17937367)CrossRefPubMed

50.

Wu Y, Meng Y, Yi W, Pan R, Liang Y, Li Y et al (2023) The ratio of monocyte count and high-density lipoprotein cholesterol mediates the association between urinary tungsten and cardiovascular disease: a study from NHANES 2005–2018. Environ Sci Pollut Res Int 30(36):85930–85939. https://doi.org/10.1007/s11356-023-28214-4CrossRefPubMed

51.

Paduraru E, Iacob D, Rarinca V, Rusu A, Jijie R, Ilie OD et al (2022) Comprehensive Review Regarding Mercury Poisoning and Its Complex Involvement in Alzheimer’s Disease. Int J Mol Sci 23(4):85930–85939. https://doi.org/10.3390/ijms23041992CrossRef

52.

Naess S, Aakre I, Lundebye AK, Ornsrud R, Kjellevold M, Markhus MW et al (2020) Mercury, lead, arsenic, and cadmium in Norwegian seafood products and consumer exposure. Food Addit Contam Part B Surveill 13(2):99–106. https://doi.org/10.1080/19393210.2020.1735533CrossRefPubMed

53.

Lazovic M, Tomovic V, Vasiljevic I, Kecojevic I, Tomovic M, Martinovic A et al (2022) Cadmium, lead, mercury, and arsenic in fresh fruits and fruit products intended for human consumption in the Republic of Serbia, 2015–2017. Food Addit Contam Part B Surveill 15(4):283–291. https://doi.org/10.1080/19393210.2022.2106313CrossRefPubMed

54.

Alfarhan M, Jafari E, Narayanan SP (2020) Acrolein: A Potential Mediator of Oxidative Damage in Diabetic Retinopathy. Biomolecules 10(11):283–291. https://doi.org/10.3390/biom10111579CrossRef

55.

Moghe A, Ghare S, Lamoreau B, Mohammad M, Barve S, McClain C et al (2015) Molecular mechanisms of acrolein toxicity: relevance to human disease. Toxicol Sci 143(2):242–255. https://doi.org/10.1093/toxsci/kfu233.PubMedPMID:25628402;PubMedCentralPMCID:PMCPMC4306719CrossRefPubMedPubMedCentral

56.

Yoshida M, Higashi K, Kobayashi E, Saeki N, Wakui K, Kusaka T et al (2010) Correlation between images of silent brain infarction, carotid atherosclerosis and white matter hyperintensity, and plasma levels of acrolein, IL-6 and CRP. Atherosclerosis 211(2):475–479. https://doi.org/10.1016/j.atherosclerosis.2010.03.031CrossRefPubMed

57.

Crowley LN, Le BL, Cicalo C, Brown J, Li Y, Kim YJ et al (2022) Acrolein, an environmental toxicant and its applications to in vivo and in vitro atherosclerosis models: An update. Environ Toxicol Pharmacol. https://doi.org/10.1016/j.etap.2022.103890CrossRefPubMed

58.

Zirak MR, Mehri S, Karimani A, Zeinali M, Hayes AW, Karimi G (2019) Mechanisms behind the atherothrombotic effects of acrolein, a review. Food Chem Toxicol 129:38–53. https://doi.org/10.1016/j.fct.2019.04.034CrossRefPubMed

59.

Henning RJ, Johnson GT, Coyle JP, Harbison RD (2017) Acrolein can cause cardiovascular disease: a review. Cardiovasc Toxicol 17(3):227–236. https://doi.org/10.1007/s12012-016-9396-5. (PubMed PMID: 28084565)CrossRefPubMed

60.

Cui W, Wu X, Feng D, Luo J, Shi Y, Guo W et al (2021) Acrolein induces systemic coagulopathy via autophagy-dependent secretion of von willebrand factor in mice after traumatic brain injury. Neurosci Bull 37(8):1160–1175. https://doi.org/10.1007/s12264-021-00681-0CrossRefPubMedPubMedCentral

61.

Xu Y, Wu L, Chen A, Xu C, Feng Q (2018) Protective effects of olive leaf extract on acrolein-exacerbated myocardial infarction via an endoplasmic reticulum stress pathway. Int J Mol Sci 19(2):1160–1175. https://doi.org/10.3390/ijms19020493CrossRef

62.

Perez CM, Hazari MS, Ledbetter AD, Haykal-Coates N, Carll AP, Cascio WE et al (2015) Acrolein inhalation alters arterial blood gases and triggers carotid body-mediated cardiovascular responses in hypertensive rats. Inhal Toxicol 27(1):54–63. https://doi.org/10.3109/08958378.2014.984881.PubMedPMID:25600140;PubMedCentralPMCID:PMCPMC4767015CrossRefPubMedPubMedCentral

63.

White SS, Birnbaum LS (2009) An overview of the effects of dioxins and dioxin-like compounds on vertebrates, as documented in human and ecological epidemiology. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 27(4):197–211. https://doi.org/10.1080/10590500903310047.PubMedPMID:19953395;PubMedCentralPMCID:PMCPMC2788749CrossRefPubMedPubMedCentral

64.

Heimstad ES, Gronstol G, Hetland KT, Alarcon JM, Rylander C, Mariussen E (2015) A survey of dioxin-like contaminants in fish from recreational fishing. Environ Monit Assess 187(8):509. https://doi.org/10.1007/s10661-015-4728-7CrossRefPubMed

65.

Bernhoft RA (2012) Mercury toxicity and treatment: a review of the literature. J Environ Public Health. https://doi.org/10.1155/2012/460508CrossRefPubMedPubMedCentral

66.

Fiolet T, Nicolas G, Casagrande C, Horvath Z, Frenoy P, Weiderpass E et al (2024) Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and mortality: EPIC cohort study in 9 European countries. Int J Hyg Environ Health. https://doi.org/10.1016/j.ijheh.2023.114287CrossRefPubMed

67.

Bergkvist C, Berglund M, Glynn A, Julin B, Wolk A, Akesson A (2016) Dietary exposure to polychlorinated biphenyls and risk of myocardial infarction in men - A population-based prospective cohort study. Environ Int 88:9–14. https://doi.org/10.1016/j.envint.2015.11.020CrossRefPubMed

68.

Bergkvist C, Kippler M, Larsson SC, Berglund M, Glynn A, Wolk A et al (2014) Dietary exposure to polychlorinated biphenyls is associated with increased risk of stroke in women. J Intern Med 276(3):248–259. https://doi.org/10.1111/joim.12194CrossRefPubMed

69.

Donat-Vargas C, Gea A, Sayon-Orea C, de la Fuente-Arrillaga C, Martinez-Gonzalez MA, Bes-Rastrollo M (2015) Association between dietary intake of polychlorinated biphenyls and the incidence of hypertension in a Spanish cohort: the Seguimiento Universidad de Navarra project. Hypertension 65(4):714–721. https://doi.org/10.1161/HYPERTENSIONAHA.114.04435CrossRefPubMed

70.

Donat-Vargas C, Moreno-Franco B, Laclaustra M, Sandoval-Insausti H, Jarauta E, Guallar-Castillon P (2020) Exposure to dietary polychlorinated biphenyls and dioxins, and its relationship with subclinical coronary atherosclerosis: The Aragon Workers’ Health Study. Environ Int. https://doi.org/10.1016/j.envint.2019.105433CrossRefPubMed

71.

Biswas SK (2016) Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox? Oxid Med Cell Longev 2016:5698931. https://doi.org/10.1155/2016/5698931CrossRefPubMedPubMedCentral

72.

Quetglas-Llabres MM, Monserrat-Mesquida M, Bouzas C, Mateos D, Ugarriza L, Gomez C et al (2023) Oxidative stress and inflammatory biomarkers are related to high intake of ultra-processed food in old adults with metabolic syndrome. Antioxidants 12(8):5698931. https://doi.org/10.3390/antiox12081532CrossRef

73.

Shi Y, Zhu H, Wang F, Chen S, Xu K, Wang L et al (2022) Daily variability in urinary artificial sweeteners and Its association with oxidative stress biomarkers. J Agric Food Chem 70(44):14264–14271. https://doi.org/10.1021/acs.jafc.2c04692CrossRefPubMed

74.

Cammisotto V, Nocella C, Bartimoccia S, Sanguigni V, Francomano D, Sciarretta S et al (2021) The Role of antioxidants supplementation in clinical practice: focus on cardiovascular risk factors. Antioxidants (Basel). 10(2):5698931. https://doi.org/10.3390/antiox10020146CrossRef

75.

Kundu N, Domingues CC, Patel J, Aljishi M, Ahmadi N, Fakhri M et al (2020) Sucralose promotes accumulation of reactive oxygen species (ROS) and adipogenesis in mesenchymal stromal cells. Stem Cell Res Ther 11(1):250. https://doi.org/10.1186/s13287-020-01753-0CrossRefPubMedPubMedCentral

76.

Griebsch LV, Theiss EL, Janitschke D, Erhardt VKJ, Erhardt T, Haas EC et al (2023) Aspartame and Its metabolites cause oxidative stress and mitochondrial and lipid alterations in SH-SY5Y Cells. Nutrients 15(6):250. https://doi.org/10.3390/nu15061467CrossRef

77.

Pan X, Wu X, Yan D, Peng C, Rao C, Yan H (2018) Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-kappaB pathways regulated by MAPKs. Toxicol Lett 288:55–64. https://doi.org/10.1016/j.toxlet.2018.02.002CrossRefPubMed

78.

Touvier M, da Costa Louzada ML, Mozaffarian D, Baker P, Juul F, Srour B (2023) Ultra-processed foods and cardiometabolic health: public health policies to reduce consumption cannot wait. BMJ. https://doi.org/10.1136/bmj-2023-075294CrossRefPubMedPubMedCentral

Title: Food contamination and cardiovascular disease: a narrative review
Authors: Gerardo Mancuso
Francesco Violi
Cristina Nocella
Publication date: 14-05-2024
Publisher: Springer International Publishing
Published in: Internal and Emergency Medicine
Print ISSN: 1828-0447
Electronic ISSN: 1970-9366
DOI: https://doi.org/10.1007/s11739-024-03610-x

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