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01-02-2006 | Case Report

Follicular dendritic cell tumor of the mediastinum: expression of fractalkine and SDF-1α as mast cell chemoattractants

Authors: Catherine Guettier, Pierre Validire, Dominique Emilie, Viviane Tricottet, Mylène Sebagh, Aurora Anjo, Jean-Louis Misset, Michel Reynes

Published in: Virchows Archiv | Issue 2/2006

Abstract

Follicular dendritic cell tumor (FDCT) is a rare tumor mainly located in laterocervical lymph nodes. We report one case of mediastinal FDCT associated with a history of bullous skin disease and clinically obvious immunosuppression. This tumor was characterized by heavy mast cell infiltration. Mast cells were in close relationship with tumor cells as demonstrated by ultrastructural examination and their presence are probably related with the strong expression of mast cell chemoattractants as fraktalkine and stromal cell-derived factor-1α by tumor cells. The long follow-up period of more than 17 years allowed to us assess the relatively indolent evolution of this tumor characterized by three slowly growing local recurrences without metastasis.

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Title: Follicular dendritic cell tumor of the mediastinum: expression of fractalkine and SDF-1α as mast cell chemoattractants
Authors: Catherine Guettier
Pierre Validire
Dominique Emilie
Viviane Tricottet
Mylène Sebagh
Aurora Anjo
Jean-Louis Misset
Michel Reynes
Publication date: 01-02-2006
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 2/2006
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-005-0143-8

At a glance: The STEP trials

Springer Medicine

Follicular dendritic cell tumor of the mediastinum: expression of fractalkine and SDF-1α as mast cell chemoattractants

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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