Top

Published in:

01-10-2011 | American Society of Breast Surgeons

Focused Ultrasound Ablation for the Treatment of Breast Cancer

Author: David R. Brenin, MD

Published in: Annals of Surgical Oncology | Issue 11/2011

Abstract

Advances in technology and changes in our understanding of tumor biology have allowed breast cancer treatment to evolve toward less disfiguring procedures. Noninvasive ablative therapy is a natural continuation of this trend. The following paper presents the concepts underpinning focused ultrasound ablation therapy for the treatment of breast cancer and reviews the investigative experience to date in the evaluation of this promising technique.

Available only for authorised users

Graham SJ, Chen L, Leitch M, Peters RD, Bronskill MJ, Foster FS, Henkelman RM, Plewes DB. Quantifying tissue damage due to focused ultrasound heating observed by MRI. Magn Reson Med. 1999;41:321–8.PubMedCrossRef

Hill CR, ter Haar GR. High intensity focused ultrasound: potential for cancer treatment. Br J Radiol. 1995;68:1296–303.PubMedCrossRef

Wu F, et al. Pathological changes in human malignant carcinoma treated with high-intensity focused ultrasound. Ultrasound Med Biol. 2001;27:1099–106.PubMedCrossRef

Wu F, Wang Z-B, Cao Y-D, Chen W-Z, Bai J, Zou J-Z, Zhu H. A randomized clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer. Br J Cancer. 2003;89:2227–33.PubMedCrossRef

Wu F, Wang Z-B, Zhu H, Chen W-Z, Zou J-Z, Bai J, Li K-Q, Jin C-B, Xie F-L, Su H-B. Extracorporeal high intensity focused ultrasound treatment for patients with breast cancer. Breast Cancer Res Treat. 2005;92:51–60.PubMedCrossRef

Furusawa H, Namba K, Thomsen S, Akiyama F, Bendet A, Tanaka C, Yasuda Y, Nakahara H. Magnetic resonance-guided focused ultrasound surgery of breast cancer: reliability and effectiveness. J Am Coll Surg. 2006;203:54–63.PubMedCrossRef

Gambos EC, Kacher DF, Furusawa H, Namba K. Breast focused ultrasound surgery with magnetic resonance guidance. Top Magn Reson Imaging. 2006;17:181–8.CrossRef

Gianfelice D, Khiat A, Amara M, Belblidia A, Boulanger Y. MR imaging-guided focused US ablation of breast cancer: histopathologic assessment of effectiveness-initial experience. Radiology. 2003;227:849–55.PubMedCrossRef

Gianfelice D, Khait A, Boulanger Y, Amara M, Beblidia A. Feasibility of magnetic resonance imaging-guided focused ultrasound surgery as an adjunct to tamoxifen therapy in high-risk surgical patients with breast carcinoma. J Vasc Interv Radiol. 2003;14:1275–82.PubMed

10.

Gianfelice D, Khiat A, Amara M, Belblindia A, Boulanger Y. MR imaging-guided focused ultrasound surgery of breast cancer: correlation of dynamic contrast-enhanced MRI with histopathological findings. Breast Cancer Res Treat. 2003;82:93–101.PubMedCrossRef

11.

Zippel DB, Papa MZ. The use of MR imaging guided focused ultrasound in breast cancer patients; a preliminary phase one study and review. Breast Cancer. 2005;12:32–8.PubMedCrossRef

12.

Khiat A, Gianfelice D, Amara M, Boulanger Y. Influence of post-treatment delay on the evaluation of the response to focused ultrasound surgery of breast cancer by dynamic contrast enhanced MRI. Br J Radiol. 2006;79:308–14.PubMedCrossRef

13.

Furusawa H, Namba K, Nakahara H, Tanaka C, Yasuda Y, Hirabara E, Imahariyama M, Komaki K. The evolving non-surgical ablation of breast cancer: MR guided focused ultrasound (MRgFUS). Breast Cancer. 2007;14:55–8.PubMedCrossRef

14.

Furusawa H. Treatment of breast cancer. Plenary session presented at the second international symposium on MR-guided focused ultrasound, October 2010, Washington, DC.

15.

Wu F, Wang Z-B, Cao Y-D, Zhu X-Q, Zhy H, Chen W-Z, Zou J-Z. Wide local ablation of localized breast cancer using high intensity focused ultrasound. J Surg Oncol. 2007;96:130–6.PubMedCrossRef

16.

Holland R, Veling SHJ, Mravunac M, Hendriks JHCL. Histologic multifocality of Tis, T1-2 breast carcinomas: implications for clinical trials of breast-conserving surgery. Cancer. 1985;56:979–90.PubMedCrossRef

17.

Bland KL, Gass J, Klimberg VS. Radiofrequency, cryoablation, and other modalities for breast cancer ablation. Surg Clin North Am. 2007;87:539–50.PubMedCrossRef

18.

Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, Jeong JH, Wolmark N. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347:1233–41.PubMedCrossRef

19.

Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, Agular M, Marubini E. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347:1227–32.PubMedCrossRef

20.

ACRIN 6674.

Title: Focused Ultrasound Ablation for the Treatment of Breast Cancer
Author: David R. Brenin, MD
Publication date: 01-10-2011
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 11/2011
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-011-2011-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Focused Ultrasound Ablation for the Treatment of Breast Cancer

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 11/2011

Lumpectomy Cavity Shaved Margins Do Not Impact Re-excision Rates in Breast Cancer Patients

A Look into the Ductoscope: Its Role in Pathologic Nipple Discharge

Potential Impact of USPSTF Recommendations on Early Diagnosis of Breast Cancer

Mammography in 40-Year-Old Women: What Difference Does It Make? The Potential Impact of the U.S. Preventative Services Task Force (USPSTF) Mammography Guidelines

Accuracy of Clinical Examination, Digital Mammogram, Ultrasound, and MRI in Determining Postneoadjuvant Pathologic Tumor Response in Operable Breast Cancer Patients

Lymph Node Ratio Should Be Considered for Incorporation into Staging for Breast Cancer