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Published in: Intensive Care Medicine 5/2020

01-05-2020 | Editorial

Focus on the frail and elderly: who should have a trial of ICU treatment?

Authors: Otavio T. Ranzani, Bruno A. M. P. Besen, Margaret S. Herridge

Published in: Intensive Care Medicine | Issue 5/2020

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Excerpt

Very old intensive care patients (VIPs ≥ 80 years of age) are vulnerable. They may deteriorate and develop multiple organ dysfunction rapidly, before having clarified their explicit goals of care to their caretakers and without an understanding of longer term patient-centered outcomes [13]. Intensive care unit (ICU) admission of such patients ‘just for monitoring’ may culminate in clinical deterioration before determination of the direction of future care. VIPs are subject to different triage practices across ICUs [1, 2, 4]. This underscores the need to determine which VIP might benefit from ICU admission and how such decisions may be informed by patient preferences and societal preferences for elderly and ageing patients [1, 2, 5, 6]. …
Literature
1.
go back to reference Guidet B, de Lange DW, Flaatten H (2018) Should this elderly patient be admitted to the ICU? Intensive Care Med 44:1926–1928CrossRef Guidet B, de Lange DW, Flaatten H (2018) Should this elderly patient be admitted to the ICU? Intensive Care Med 44:1926–1928CrossRef
2.
go back to reference Flaatten H, de Lange DW, Artigas A, Bin D, Moreno R, Christensen S, Joynt GM, Bagshaw SM, Sprung CL, Benoit D, Soares M, Guidet B (2017) The status of intensive care medicine research and a future agenda for very old patients in the ICU. Intensive Care Med 43:1319–1328CrossRef Flaatten H, de Lange DW, Artigas A, Bin D, Moreno R, Christensen S, Joynt GM, Bagshaw SM, Sprung CL, Benoit D, Soares M, Guidet B (2017) The status of intensive care medicine research and a future agenda for very old patients in the ICU. Intensive Care Med 43:1319–1328CrossRef
3.
go back to reference Vink EE, Azoulay E, Caplan A, Kompanje EJO, Bakker J (2018) Time-limited trial of intensive care treatment: an overview of current literature. Intensive Care Med 44:1369–1377CrossRef Vink EE, Azoulay E, Caplan A, Kompanje EJO, Bakker J (2018) Time-limited trial of intensive care treatment: an overview of current literature. Intensive Care Med 44:1369–1377CrossRef
4.
go back to reference Guidet B, Leblanc G, Simon T, Woimant M, Quenot JP, Ganansia O, Maignan M, Yordanov Y, Delerme S, Doumenc B, Fartoukh M, Charestan P, Trognon P, Galichon B, Javaud N, Patzak A, Garrouste-Orgeas M, Thomas C, Azerad S, Pateron D, Boumendil A, Network I-CS (2017) Effect of systematic intensive care unit triage on long-term mortality among critically ill elderly patients in France: a randomized clinical trial. JAMA 318:1450–1459CrossRef Guidet B, Leblanc G, Simon T, Woimant M, Quenot JP, Ganansia O, Maignan M, Yordanov Y, Delerme S, Doumenc B, Fartoukh M, Charestan P, Trognon P, Galichon B, Javaud N, Patzak A, Garrouste-Orgeas M, Thomas C, Azerad S, Pateron D, Boumendil A, Network I-CS (2017) Effect of systematic intensive care unit triage on long-term mortality among critically ill elderly patients in France: a randomized clinical trial. JAMA 318:1450–1459CrossRef
5.
go back to reference Forte DN, Kawai F, Cohen C (2018) A bioethical framework to guide the decision-making process in the care of seriously ill patients. BMC Med Ethics 19:78CrossRef Forte DN, Kawai F, Cohen C (2018) A bioethical framework to guide the decision-making process in the care of seriously ill patients. BMC Med Ethics 19:78CrossRef
6.
go back to reference Flaatten H, Oeyen S, deLange DW (2018) Predicting outcomes in very old ICU patients: time to focus on the past? Intensive Care Med 44:1344–1345CrossRef Flaatten H, Oeyen S, deLange DW (2018) Predicting outcomes in very old ICU patients: time to focus on the past? Intensive Care Med 44:1344–1345CrossRef
7.
go back to reference Valley TS, Sjoding MW, Ryan AM, Iwashyna TJ, Cooke CR (2015) Association of intensive care unit admission with mortality among older patients with pneumonia. JAMA 314:1272–1279CrossRef Valley TS, Sjoding MW, Ryan AM, Iwashyna TJ, Cooke CR (2015) Association of intensive care unit admission with mortality among older patients with pneumonia. JAMA 314:1272–1279CrossRef
8.
go back to reference Harris S, Singer M, Sanderson C, Grieve R, Harrison D, Rowan K (2018) Impact on mortality of prompt admission to critical care for deteriorating ward patients: an instrumental variable analysis using critical care bed strain. Intensive Care Med 44:606–615CrossRef Harris S, Singer M, Sanderson C, Grieve R, Harrison D, Rowan K (2018) Impact on mortality of prompt admission to critical care for deteriorating ward patients: an instrumental variable analysis using critical care bed strain. Intensive Care Med 44:606–615CrossRef
9.
go back to reference Zampieri FG, Iwashyna TJ, Viglianti EM, Taniguchi LU, Viana WN, Costa R, Correa TD, Moreira CEN, Maia MO, Moralez GM, Lisboa T, Ferez MA, Freitas CEF, de Carvalho CB, Mazza BF, Lima MFA, Ramos GV, Silva AR, Bozza FA, Salluh JIF, Soares M, Investigators OS (2018) Association of frailty with short-term outcomes, organ support and resource use in critically ill patients. Intensive Care Med 44:1512–1520CrossRef Zampieri FG, Iwashyna TJ, Viglianti EM, Taniguchi LU, Viana WN, Costa R, Correa TD, Moreira CEN, Maia MO, Moralez GM, Lisboa T, Ferez MA, Freitas CEF, de Carvalho CB, Mazza BF, Lima MFA, Ramos GV, Silva AR, Bozza FA, Salluh JIF, Soares M, Investigators OS (2018) Association of frailty with short-term outcomes, organ support and resource use in critically ill patients. Intensive Care Med 44:1512–1520CrossRef
10.
go back to reference Flaatten H, Clegg A (2018) Frailty: we need valid and reliable tools in critical care. Intensive Care Med 44:1973–1975CrossRef Flaatten H, Clegg A (2018) Frailty: we need valid and reliable tools in critical care. Intensive Care Med 44:1973–1975CrossRef
11.
go back to reference Muscedere J, Waters B, Varambally A, Bagshaw SM, Boyd JG, Maslove D, Sibley S, Rockwood K (2017) The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis. Intensive Care Med 43:1105–1122CrossRef Muscedere J, Waters B, Varambally A, Bagshaw SM, Boyd JG, Maslove D, Sibley S, Rockwood K (2017) The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis. Intensive Care Med 43:1105–1122CrossRef
12.
go back to reference Guidet B, Flaatten H, Boumendil A, Morandi A, Andersen FH, Artigas A, Bertolini G, Cecconi M, Christensen S, Faraldi L, Fjolner J, Jung C, Marsh B, Moreno R, Oeyen S, Ohman CA, Pinto BB, Soliman IW, Szczeklik W, Valentin A, Watson X, Zafeiridis T, De Lange DW, Group VIPs (2018) Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit. Intensive Care Med 44:1027–1038CrossRef Guidet B, Flaatten H, Boumendil A, Morandi A, Andersen FH, Artigas A, Bertolini G, Cecconi M, Christensen S, Faraldi L, Fjolner J, Jung C, Marsh B, Moreno R, Oeyen S, Ohman CA, Pinto BB, Soliman IW, Szczeklik W, Valentin A, Watson X, Zafeiridis T, De Lange DW, Group VIPs (2018) Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit. Intensive Care Med 44:1027–1038CrossRef
13.
go back to reference Bagshaw SM, Adhikari NKJ, Burns KEA, Friedrich JO, Bouchard J, Lamontagne F, McIntrye LA, Cailhier JF, Dodek P, Stelfox HT, Herridge M, Lapinsky S, Muscedere J, Barton J, Griesdale D, Soth M, Ambosta A, Lebovic G, Wald R, Canadian Critical Care Trials G (2019) Selection and receipt of kidney replacement in critically ill older patients with AKI. Clin J Am Soc Nephrol 14:496–505CrossRef Bagshaw SM, Adhikari NKJ, Burns KEA, Friedrich JO, Bouchard J, Lamontagne F, McIntrye LA, Cailhier JF, Dodek P, Stelfox HT, Herridge M, Lapinsky S, Muscedere J, Barton J, Griesdale D, Soth M, Ambosta A, Lebovic G, Wald R, Canadian Critical Care Trials G (2019) Selection and receipt of kidney replacement in critically ill older patients with AKI. Clin J Am Soc Nephrol 14:496–505CrossRef
14.
go back to reference Mentzelopoulos SD, Slowther AM, Fritz Z, Sandroni C, Xanthos T, Callaway C, Perkins GD, Newgard C, Ischaki E, Greif R, Kompanje E, Bossaert L (2018) Ethical challenges in resuscitation. Intensive Care Med 44:703–716CrossRef Mentzelopoulos SD, Slowther AM, Fritz Z, Sandroni C, Xanthos T, Callaway C, Perkins GD, Newgard C, Ischaki E, Greif R, Kompanje E, Bossaert L (2018) Ethical challenges in resuscitation. Intensive Care Med 44:703–716CrossRef
15.
go back to reference Herridge MS, Chu LM, Matte A, Tomlinson G, Chan L, Thomas C, Friedrich JO, Mehta S, Lamontagne F, Levasseur M, Ferguson ND, Adhikari NK, Rudkowski JC, Meggison H, Skrobik Y, Flannery J, Bayley M, Batt J, Santos CD, Abbey SE, Tan A, Lo V, Mathur S, Parotto M, Morris D, Flockhart L, Fan E, Lee CM, Wilcox ME, Ayas N, Choong K, Fowler R, Scales DC, Sinuff T, Cuthbertson BH, Rose L, Robles P, Burns S, Cypel M, Singer L, Chaparro C, Chow CW, Keshavjee S, Brochard L, Hebert P, Slutsky AS, Marshall JC, Cook D, Cameron JI, Investigators RP, Canadian Critical Care Trials G (2016) The RECOVER program: disability risk groups and 1-year outcome after 7 or more days of mechanical ventilation. Am J Respir Crit Care Med 194:831–844CrossRef Herridge MS, Chu LM, Matte A, Tomlinson G, Chan L, Thomas C, Friedrich JO, Mehta S, Lamontagne F, Levasseur M, Ferguson ND, Adhikari NK, Rudkowski JC, Meggison H, Skrobik Y, Flannery J, Bayley M, Batt J, Santos CD, Abbey SE, Tan A, Lo V, Mathur S, Parotto M, Morris D, Flockhart L, Fan E, Lee CM, Wilcox ME, Ayas N, Choong K, Fowler R, Scales DC, Sinuff T, Cuthbertson BH, Rose L, Robles P, Burns S, Cypel M, Singer L, Chaparro C, Chow CW, Keshavjee S, Brochard L, Hebert P, Slutsky AS, Marshall JC, Cook D, Cameron JI, Investigators RP, Canadian Critical Care Trials G (2016) The RECOVER program: disability risk groups and 1-year outcome after 7 or more days of mechanical ventilation. Am J Respir Crit Care Med 194:831–844CrossRef
16.
go back to reference Guidet B, de Lange DW, Boumendil A, Leaver S, Watson X, Boulanger C, Szczeklik W, Artigas A, Morandi A, Andersen F, Zafeiridis T, Jung C, Moreno R, Walther S, Oeyen S, Schefold JC, Cecconi M, Marsh B, Joannidis M, Nalapko Y, Elhadi M, Fjolner J, Flaatten H, Group VIPs (2020) The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study. Intensive Care Med 46:57–69CrossRef Guidet B, de Lange DW, Boumendil A, Leaver S, Watson X, Boulanger C, Szczeklik W, Artigas A, Morandi A, Andersen F, Zafeiridis T, Jung C, Moreno R, Walther S, Oeyen S, Schefold JC, Cecconi M, Marsh B, Joannidis M, Nalapko Y, Elhadi M, Fjolner J, Flaatten H, Group VIPs (2020) The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study. Intensive Care Med 46:57–69CrossRef
Metadata
Title
Focus on the frail and elderly: who should have a trial of ICU treatment?
Authors
Otavio T. Ranzani
Bruno A. M. P. Besen
Margaret S. Herridge
Publication date
01-05-2020
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 5/2020
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-020-05963-1

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