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Clinical and Molecular Allergy
Published in: Clinical and Molecular Allergy 1/2018

Open Access 01-12-2018 | Review

Focus on the agents most frequently responsible for perioperative anaphylaxis

Authors: E. Di Leo, P. Delle Donne, G. F. Calogiuri, L. Macchia, E. Nettis

Published in: Clinical and Molecular Allergy | Issue 1/2018

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Abstract

Adverse reactions (ARs) to drugs administered during general anesthesia may be very severe and life-threatening, with a mortality rate ranging from 3 to 9%. The adverse reactions to drugs may be IgE and non-IgE-mediated. Neuromuscular blocking agents (NMBA) represent the first cause of perioperative reactions during general anesthesia followed by latex, antibiotics, hypnotic agents, opioids, colloids, dyes and antiseptics (chlorhexidine). All these substances (i.e. NMBA, anesthetics, antibiotics, latex devices) may cause severe systemic non-IgE-mediated reactions or fatal anaphylactic events even in the absence of any evident risk factor in the patient’s anamnesis. For this reason, in order to minimize perioperative anaphylactic reactions, it is important to have rapid, specific, sensitive in vitro diagnostic tests able to confirm the clinical diagnosis of acute anaphylaxis.
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Metadata
Title
Focus on the agents most frequently responsible for perioperative anaphylaxis
Authors
E. Di Leo
P. Delle Donne
G. F. Calogiuri
L. Macchia
E. Nettis
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Clinical and Molecular Allergy / Issue 1/2018
Electronic ISSN: 1476-7961
DOI
https://doi.org/10.1186/s12948-018-0094-7

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