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European Journal of Pediatrics
Published in: European Journal of Pediatrics 6/2011

01-06-2011 | Short Report

Focal nodular hyperplasia of the liver after intensive treatment for pediatric cancer: is hematopoietic stem cell transplantation a risk factor?

Authors: Riccardo Masetti, Carlotta Biagi, Katharina Kleinschmidt, Arcangelo Prete, Federico Baronio, Antonio Colecchia, Davide Festi, Andrea Pession

Published in: European Journal of Pediatrics | Issue 6/2011

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Abstract

Focal nodular hyperplasia (FNH) is a benign hepatic lesion very rarely described in the pediatric population. It has been reported more frequently in patients treated for pediatric cancers with chemotherapy or hematopoietic stem cell transplantation. The use of high dosage of alkylating agents, the occurrence of venous occlusive disease, graft-versus-host disease, and other variables linked to the hematopoietic stem cell transplantation procedure can represent risk factors for the development of FNH in the pediatric age. The discovery of hepatic nodules in the follow-up of patients treated for malignancies suggests recurrence of disease and raises a diagnostic dilemma. Here we describe possible risk factors, clinical and radiological findings of eight pediatric patients who developed focal nodular hyperplasia after hematopoietic stem cell transplantation. The aim of this report is to provide useful diagnostic tools to facilitate accurate diagnosis of FNH and suggest a correct management of this benign lesion during postcancer follow-up.
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Metadata
Title
Focal nodular hyperplasia of the liver after intensive treatment for pediatric cancer: is hematopoietic stem cell transplantation a risk factor?
Authors
Riccardo Masetti
Carlotta Biagi
Katharina Kleinschmidt
Arcangelo Prete
Federico Baronio
Antonio Colecchia
Davide Festi
Andrea Pession
Publication date
01-06-2011
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 6/2011
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-010-1388-z

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