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01-10-2011 | Letter

Fish oil and sepsis: we still need more trials

Author: Flavia R Machado

Published in: Critical Care | Issue 5/2011

Excerpt

I read with concern the recently published article by Pontes-Arruda and colleagues addressing eicosapentaenoic acid/γ-linolenic acid (EPA/GLA) use in septic patients [1]. …

Pontes-Arruda A, Martins LF, de Lima SM, Isola AM, Toledo D, Rezende E, Maia M, Magnan GB, Investigating Nutritional Therapy with EPA, GLA and Antioxidants Role in Sepsis Treatment (INTERSEPT) Study Group: Enteral nutrition with eicosapentaenoic acid, γ-linolenic acid and antioxidants in the early treatment of sepsis: results from a multicenter, prospective, randomized, double-blinded, controlled study: the INTERSEPT study. Crit Care 2011, 15: R144. 10.1186/cc10267PubMedCentralCrossRefPubMed

Early Versus Delayed Enteral Feeding and Omega-3 Fatty Acid/Antioxidant Supplementation for Treating People with Acute Lung Injury or Acute Respiratory Distress Syndrome (The EDEN-Omega Study)[http://www.clinicaltrials.gov/ct2/show/record/NCT00609180?term=eden+omega&rank=1]

Gadek JE, DeMichele SJ, Karlstad MD, Pacht ER, Donahoe M, Albertson TE, Van Hoozen C, Wennberg AK, Nelson JL, Noursalehi M: Effect of enteral feeding with eicosapentaenoic acid, γ-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Enteral Nutrition in ARDS Study Group. Crit Care Med 1999, 27: 1409-1420. 10.1097/00003246-199908000-00001CrossRefPubMed

Singer P, Theilla M, Fisher H, Gibstein L, Grozovski E, Cohen J: Benefit of an enteral diet enriched with eicosapentaenoic acid and γ-linolenic acid in ventilated patients with acute lung injury. Crit Care Med 2006, 34: 1033-1038. 10.1097/01.CCM.0000206111.23629.0ACrossRefPubMed

Pontes-Arruda A, Aragão AM, Albuquerque JD: The effects of enteral feeding with eicosapentaenoic acid, γ-linolenic acid and antioxidants in mechanically ventilated patients with severe sepsis and septic shock. Crit Care Med 2006, 34: 2325-2333. 10.1097/01.CCM.0000234033.65657.B6CrossRefPubMed

Pontes-Arruda A, Demichele S, Seth A, Singer P: The use of an inflammationmodulating diet in patients with acute lung injury or acute respiratory distress syndrome: a meta-analysis of outcome data. JPEN J Parenter Enteral Nutr 2008, 32: 596-605. 10.1177/0148607108324203CrossRefPubMed

Martindale RG, McClave SA, Vanek VW, McCarthy M, Roberts P, Taylor B, Ochoa JB, Napolitano L, Cresci G, American College of Critical Care Medicine; ASPEN Board of Directors: Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition: executive summary. Crit Care Med 2009, 37: 1757-1761. 10.1097/CCM.0b013e3181a40116CrossRefPubMed

Kreymann KG, Berger MM, Deutz NEP, Hiesmayr M, Jolliet P, Kazandjiev G, Nitenberg G, van den Berghe G, Wernerman J: ESPEN guidelines on enteral nutrition: intensive care. Clin Nutr 2006, 25: 210-223. 10.1016/j.clnu.2006.01.021CrossRefPubMed

Title: Fish oil and sepsis: we still need more trials
Author: Flavia R Machado
Publication date: 01-10-2011
Publisher: BioMed Central
Published in: Critical Care / Issue 5/2011
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc10431

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