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Journal of the Association for Research in Otolaryngology

Published in:

10-05-2023 | General research

Finite-Element Modelling Based on Optical Coherence Tomography and Corresponding X-ray MicroCT Data for Three Human Middle Ears

Authors: Marzieh Golabbakhsh, Xuan Wang, Dan MacDougall, Joshua Farrell, Thomas Landry, W. Robert J. Funnell, Robert Adamson

Published in: Journal of the Association for Research in Otolaryngology | Issue 3/2023

Abstract

Purpose

Optical coherence tomography (OCT) is an emerging imaging modality which is non-invasive, can be employed in vivo, and can record both anatomy and vibrations. The purpose here is to explore the application of finite-element (FE) modelling to OCT data.

Methods

We recorded vibrations for three human cadaver middle ears using OCT. We also have X-ray microCT images from the same ears. Three FE models were built based on geometries obtained from the microCT images. The material properties and boundary conditions of the models were obtained from previously reported studies.

Results

Tympanic-membrane (TM) vibration patterns were computed for the three models and compared with the patterns measured using OCT. Frequency responses were also computed for all three models for several locations in the middle ear and compared with the OCT displacements and with the literature. The three models were compared with each other in terms of geometry and function. Parameter sensitivity analyses were done and the results were compared among the models and with the literature. The simulated TM displacement patterns are qualitatively similar to the OCT results. The simulated displacements are closer to the OCT results for 500 Hz and 1 kHz but the differences are greater at 2 kHz.

Conclusion

This study provides an initial look at the combined use of OCT measurements and FE modelling based on subject-specific anatomy. The geometries and parameters of the existing FE models could be modified for individual patients in the future to help identify abnormalities in the middle ear.

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Title: Finite-Element Modelling Based on Optical Coherence Tomography and Corresponding X-ray MicroCT Data for Three Human Middle Ears
Authors: Marzieh Golabbakhsh
Xuan Wang
Dan MacDougall
Joshua Farrell
Thomas Landry
W. Robert J. Funnell
Robert Adamson
Publication date: 10-05-2023
Publisher: Springer US
Published in: Journal of the Association for Research in Otolaryngology / Issue 3/2023
Print ISSN: 1525-3961
Electronic ISSN: 1438-7573
DOI: https://doi.org/10.1007/s10162-023-00899-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Finite-Element Modelling Based on Optical Coherence Tomography and Corresponding X-ray MicroCT Data for Three Human Middle Ears

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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