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01-12-2005 | Commentary

Fine-tuning insulin and nitric oxide signalling by turning up the AMPs: new insights into AMP-activated protein kinase signalling

Authors: Y. C. Long, J. R. Zierath

Published in: Diabetologia | Issue 12/2005

Excerpt

The regulation of glucose homeostasis is critical for the proper functioning of the body. Unsurprisingly, multiple molecular pathways have evolved to regulate glucose uptake and nutrient metabolism. Under postprandial conditions, when plasma glucose is elevated, insulin stimulates glucose uptake in skeletal muscle, adipose tissue and the heart via activation of phosphatidylinositol 3-kinase (PI3-kinase). The anabolic action of insulin also increases glycogen synthesis via inactivation of glycogen synthase kinase 3 (GSK3), and protein synthesis by stimulation of mammalian target of rapamycin (mTOR). …

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Title: Fine-tuning insulin and nitric oxide signalling by turning up the AMPs: new insights into AMP-activated protein kinase signalling
Authors: Y. C. Long
J. R. Zierath
Publication date: 01-12-2005
Publisher: Springer-Verlag
Published in: Diabetologia / Issue 12/2005
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-005-0032-3

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