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Child's Nervous System
Published in: Child's Nervous System 7/2017

01-07-2017 | Case Report

Finding of IDH1 R132H mutation in histologically non-neoplastic glial tissue changes surgical strategies, a case report

Authors: Christian Baastrup Søndergaard, David Scheie, Astrid Marie Sehested, Jane Skjøth-Rasmussen

Published in: Child's Nervous System | Issue 7/2017

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Abstract

Introduction

In 2016, the WHO classification of diffuse astrocytoma began to include isocitrate dehydrogenase (IDH) mutation in addition to histology.

Results

We here demonstrate a case where a 14-year-old boy presented with a parietal tumor with no histological evidence of neoplasia but with an IDH1 mutation. Due to the IDH1 R132H mutation, the patient was diagnosed with diffuse astrocytoma WHO grade II and underwent successful gross total resection of this near-eloquently located tumor.

Conclusion

This case exemplifies how inclusion of immunohistochemistry in tumor classification alters surgical strategy and might improve accuracy and time to diagnosis.
Literature
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Metadata
Title
Finding of IDH1 R132H mutation in histologically non-neoplastic glial tissue changes surgical strategies, a case report
Authors
Christian Baastrup Søndergaard
David Scheie
Astrid Marie Sehested
Jane Skjøth-Rasmussen
Publication date
01-07-2017
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 7/2017
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-017-3348-7

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