A 78-years-old lady presented with intermittent fever for 1 month, twitching of the limbs, urinary incontinence and hematuria for 1 day. Laboratory tests showed hemoglobin of 89 g/L, total leukocyte count-21.83 × 109/L with 85% neutrophils. Total bilirubin (53.49 μmol/L) and indirect bilirubin (32.08 μmol/L) were elevated. The peripheral blood smear showed erythrophagocytosis by neutrophil and rare monocytes (Fig. 1a–c) as well as Dohle bodies and vacuolar degeneration within neutrophils (Fig. 1d).
Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.