Skip to main content
Top
Published in: BMC Oral Health 1/2021

Open Access 01-12-2021 | Fibromatosis | Case report

Seven-year follow-up of a patient with hereditary gingival fibromatosis treated with a multidisciplinary approach: case report

Authors: Ning Li, Wenfang Wang, Yuanyuan Sun, Hongning Wang, Tiejun Wang

Published in: BMC Oral Health | Issue 1/2021

Login to get access

Abstract

Background

Hereditary gingival fibromatosis (HGF) is rare in clinical practice, and the long-term results of the combined orthodontic-periodontal treatment of HGF are rarely reported.

Case presentation

This study reports for the first time the results of seven years of follow-up in a seven-year-old girl with HGF. The diagnosis was confirmed by clinical signs, family history and histopathological examination. First, periodontal scaling and oral hygiene reinforcement were performed regularly in the mixed dentition stage. Next, gingivoplasty was performed on the permanent dentition. Two months after the surgery, treatment with fixed orthodontic appliances was conducted. The teeth were polished on a monthly basis, and oral hygiene was reinforced to control gingival enlargement. Gingival hypertrophy recurred slightly, and gingivectomies were performed in the months following the start of orthodontic treatment. Follow-up was performed for 24 months with orthodontic retention, and gingival enlargement remained stable after the combined treatment.

Conclusions

The risk of gingival hyperplasia recurrence during and after orthodontic treatment is high, but satisfying long-term outcomes can be achieved with gingivectomy, malocclusion correction, and regular follow-up maintenance.
Literature
1.
go back to reference Kather J, Salgado MA, Salgado UF, Cortelli JR, Pallos D. Clinical and histomorphometric characteristics of three different families with hereditary gingival fibromatosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105(3):348–52.CrossRef Kather J, Salgado MA, Salgado UF, Cortelli JR, Pallos D. Clinical and histomorphometric characteristics of three different families with hereditary gingival fibromatosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105(3):348–52.CrossRef
2.
go back to reference Kelekis-Cholakis A, Wiltshire WA, Birek C. Treatment and long-term follow-up of a patient with hereditary gingival fibromatosis: a case report. J Can Dent Assoc. 2002;68(5):290–4.PubMed Kelekis-Cholakis A, Wiltshire WA, Birek C. Treatment and long-term follow-up of a patient with hereditary gingival fibromatosis: a case report. J Can Dent Assoc. 2002;68(5):290–4.PubMed
3.
go back to reference Bayram Y, White JJ, Elcioglu N, et al. REST final-exontruncating mutations cause hereditary gingival fibromatosis. Am J Hum Genet. 2017;101(1):149–56.CrossRef Bayram Y, White JJ, Elcioglu N, et al. REST final-exontruncating mutations cause hereditary gingival fibromatosis. Am J Hum Genet. 2017;101(1):149–56.CrossRef
4.
go back to reference Resende EP, Xavier MT, Matos S, Antunes AC, Silva HC. Nonsyndromic hereditary gingival fibromatosis: Characterization of a family and review of genetic etiology. Spec Care Dentist. 2020;40(3):320–8.CrossRef Resende EP, Xavier MT, Matos S, Antunes AC, Silva HC. Nonsyndromic hereditary gingival fibromatosis: Characterization of a family and review of genetic etiology. Spec Care Dentist. 2020;40(3):320–8.CrossRef
5.
go back to reference Michaud PL, Patel A. Hereditary gingival fibromatosis with extreme ridge thickness and insufficient interarch distance: a clinical report of surgical and prosthetic management. J Prosthet Dent. 2016;116(1):15–20.CrossRef Michaud PL, Patel A. Hereditary gingival fibromatosis with extreme ridge thickness and insufficient interarch distance: a clinical report of surgical and prosthetic management. J Prosthet Dent. 2016;116(1):15–20.CrossRef
6.
go back to reference Martelli-Junior H, Lemos DP, Silva CO, et al. Hereditary gingival fibromatosis: report of a five-generation family using cellular proliferation analysis. J Periodontol. 2005;76(12):2299–305.CrossRef Martelli-Junior H, Lemos DP, Silva CO, et al. Hereditary gingival fibromatosis: report of a five-generation family using cellular proliferation analysis. J Periodontol. 2005;76(12):2299–305.CrossRef
7.
go back to reference Gao Q, Yang K, Chen D, Song Y, Qiao W, Sun X, Meng L, Bian Z. Antifibrotic potential of MiR-335-3p in hereditary gingival fibromatosis. J Dent Res. 2019;98(10):1140–9.CrossRef Gao Q, Yang K, Chen D, Song Y, Qiao W, Sun X, Meng L, Bian Z. Antifibrotic potential of MiR-335-3p in hereditary gingival fibromatosis. J Dent Res. 2019;98(10):1140–9.CrossRef
8.
go back to reference Iizuka S, Abdullah C, Buschman MD, et al. The role of Tks adap- tor proteins in invadopodia formation, growth and metastasis of melanoma. Oncotarget. 2016;7(48):78473–86.CrossRef Iizuka S, Abdullah C, Buschman MD, et al. The role of Tks adap- tor proteins in invadopodia formation, growth and metastasis of melanoma. Oncotarget. 2016;7(48):78473–86.CrossRef
9.
go back to reference Bekhouche M, Leduc C, Dupont L, et al. Determination of the substrate repertoire of ADAMTS 2,3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-β signaling as primary targets. FASEB J. 2016;30(5):1741–56.CrossRef Bekhouche M, Leduc C, Dupont L, et al. Determination of the substrate repertoire of ADAMTS 2,3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-β signaling as primary targets. FASEB J. 2016;30(5):1741–56.CrossRef
10.
go back to reference Shi J, Lin W, Li X, Zhang F, Hong X. Hereditary gingival fibromatosis: a three-generation case and pathogenic mechanism research on progress of the disease. J Periodontol. 2011;82(7):1089–95.CrossRef Shi J, Lin W, Li X, Zhang F, Hong X. Hereditary gingival fibromatosis: a three-generation case and pathogenic mechanism research on progress of the disease. J Periodontol. 2011;82(7):1089–95.CrossRef
11.
go back to reference Almiñana-Pastor PJ, Buitrago-Vera PJ, Alpiste-Illueca FM, Catalá-Pizarro M. Hereditary gingival fibromatosis: Characteristics and treatment approach. J Clin Exp Dent. 2017;9(4):e599–602.PubMedPubMedCentral Almiñana-Pastor PJ, Buitrago-Vera PJ, Alpiste-Illueca FM, Catalá-Pizarro M. Hereditary gingival fibromatosis: Characteristics and treatment approach. J Clin Exp Dent. 2017;9(4):e599–602.PubMedPubMedCentral
12.
go back to reference Häkkinen L, Csiszar A. Hereditary gingival fibromatosis: characteristics and novel putative pathogenic mechanisms. J Dent Res. 2007;86(1):25–34.CrossRef Häkkinen L, Csiszar A. Hereditary gingival fibromatosis: characteristics and novel putative pathogenic mechanisms. J Dent Res. 2007;86(1):25–34.CrossRef
13.
go back to reference Boutiou E, Ziogas IA, Giannis D, Doufexi AE. Hereditary gingival fibromatosis in children: a systematic review of the literature. Clin Oral Investig. 2021;25(6):3599–607.CrossRef Boutiou E, Ziogas IA, Giannis D, Doufexi AE. Hereditary gingival fibromatosis in children: a systematic review of the literature. Clin Oral Investig. 2021;25(6):3599–607.CrossRef
14.
go back to reference Jose A, Butler A, Payne D, et al. A randomised clinical study to evaluate the efficacy of alcohol-free or alcohol-containing mouthrinses with chlorhexidine on gingival bleeding. Br Dent J. 2015;219(3):125–30.CrossRef Jose A, Butler A, Payne D, et al. A randomised clinical study to evaluate the efficacy of alcohol-free or alcohol-containing mouthrinses with chlorhexidine on gingival bleeding. Br Dent J. 2015;219(3):125–30.CrossRef
15.
go back to reference Moorrees CF, Fanning EA, Hunt EE Jr. Age variation of formation stages for ten permanent teeth. J Dent Res. 1963;42:1490–502.CrossRef Moorrees CF, Fanning EA, Hunt EE Jr. Age variation of formation stages for ten permanent teeth. J Dent Res. 1963;42:1490–502.CrossRef
16.
go back to reference Ramer M, Marrone J, Stahl B, Burakoff R. Hereditary gingival fibromatosis: identification, treatment, control. J Am Dent Assoc. 1996;127(4):493–5.CrossRef Ramer M, Marrone J, Stahl B, Burakoff R. Hereditary gingival fibromatosis: identification, treatment, control. J Am Dent Assoc. 1996;127(4):493–5.CrossRef
17.
go back to reference Guglielmi F, Staderini E, Iavarone F, Di Tonno L, Gallenzi P. Zimmermann-laband-1 syndrome: clinical, histological, and proteomic findings of a 3-year-old patient with hereditary gingival fibromatosis. Biomedicines. 2019;7(3):48.CrossRef Guglielmi F, Staderini E, Iavarone F, Di Tonno L, Gallenzi P. Zimmermann-laband-1 syndrome: clinical, histological, and proteomic findings of a 3-year-old patient with hereditary gingival fibromatosis. Biomedicines. 2019;7(3):48.CrossRef
18.
go back to reference Ramakrishnan T, Kaur M. Multispeciality approach in the management of patient with hereditary gingival fibromatosis: 1-year followup: a case report. Int J Dent. 2010;2010:575979.CrossRef Ramakrishnan T, Kaur M. Multispeciality approach in the management of patient with hereditary gingival fibromatosis: 1-year followup: a case report. Int J Dent. 2010;2010:575979.CrossRef
19.
go back to reference Coletta RD, Graner E. Hereditary gingival fibromatosis: a systematic review. J Periodontol. 2006;77(5):753–64.CrossRef Coletta RD, Graner E. Hereditary gingival fibromatosis: a systematic review. J Periodontol. 2006;77(5):753–64.CrossRef
20.
go back to reference Yussif NM, Abdul Aziz MA. Towards the targeted management of hereditary gingival fibromatosis. Med Hypotheses. 2018;121:188–90.CrossRef Yussif NM, Abdul Aziz MA. Towards the targeted management of hereditary gingival fibromatosis. Med Hypotheses. 2018;121:188–90.CrossRef
21.
go back to reference Gandhi M, Tandon S, Sharma M, et al. Nonsyndromic gingival fibromatosis: a rare case report. Int J Clin Pediatr Dent. 2018;11(3):250–3.CrossRef Gandhi M, Tandon S, Sharma M, et al. Nonsyndromic gingival fibromatosis: a rare case report. Int J Clin Pediatr Dent. 2018;11(3):250–3.CrossRef
22.
go back to reference Bittencourt LP, Campos V, Moliterno L, et al. Hereditary gingival fibromatosis: review of the literature and a case report. Quintessence Int. 2000;31(6):415–8.PubMed Bittencourt LP, Campos V, Moliterno L, et al. Hereditary gingival fibromatosis: review of the literature and a case report. Quintessence Int. 2000;31(6):415–8.PubMed
23.
go back to reference Gonalves CF, Mundim AP, Fernando R, et al. Hereditary gingival fibromatosis: a case report with seven-year follow-up. Acta Stomatol Croat. 2018;52(3):254–8.CrossRef Gonalves CF, Mundim AP, Fernando R, et al. Hereditary gingival fibromatosis: a case report with seven-year follow-up. Acta Stomatol Croat. 2018;52(3):254–8.CrossRef
24.
go back to reference Clocheret K, Dekeyser C, Carels C, Willems G. Idiopathic gingival hyperplasia and orthodontic treatment: a case report. J Orthod. 2003;30(1):13–9.CrossRef Clocheret K, Dekeyser C, Carels C, Willems G. Idiopathic gingival hyperplasia and orthodontic treatment: a case report. J Orthod. 2003;30(1):13–9.CrossRef
25.
go back to reference Gawron K, Lazarz-Bartyzel K, Kowalska A, et al. Fibroblasts from recurrent fibrotic overgrowths reveal high rate of proliferation in vitro findings from the study of hereditary and idiopathic gingival fibromatosis. Connect Tissue Res. 2019;60(1):29–39.CrossRef Gawron K, Lazarz-Bartyzel K, Kowalska A, et al. Fibroblasts from recurrent fibrotic overgrowths reveal high rate of proliferation in vitro findings from the study of hereditary and idiopathic gingival fibromatosis. Connect Tissue Res. 2019;60(1):29–39.CrossRef
Metadata
Title
Seven-year follow-up of a patient with hereditary gingival fibromatosis treated with a multidisciplinary approach: case report
Authors
Ning Li
Wenfang Wang
Yuanyuan Sun
Hongning Wang
Tiejun Wang
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2021
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-021-01830-7

Other articles of this Issue 1/2021

BMC Oral Health 1/2021 Go to the issue