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Clinical Oral Investigations

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01-06-2021 | Fibromatosis | Original Article

Hereditary gingival fibromatosis in children: a systematic review of the literature

Authors: Eirini Boutiou, Ioannis A. Ziogas, Dimitrios Giannis, Aikaterini-Elisavet Doufexi

Published in: Clinical Oral Investigations | Issue 6/2021

Abstract

Objectives

Hereditary gingival fibromatosis (HGF) is an uncommon, inherited condition with slow and progressive fibrous hyperplasia of the gingiva. Due to its association with mastication, speech, and occlusion problems, early diagnosis is important. We sought to summarize the available data regarding the epidemiology, clinical characteristics, and outcomes of children with HGF (< 18 years).

Methods

A systematic literature review of the MEDLINE and Cochrane Library databases was conducted with respect to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (end-of-search date: March 1, 2019).

Results

A total of 99 articles reporting on 146 patients were included. The mean age was 10.82 ± 3.93 years, and generalized gingival enlargement was seen in 97.16% (95% CI 92.69 to 99.14). Jaw, gingival, and teeth abnormalities; poor oral hygiene; eating; or speech difficulties were typical HGF-induced, while 60.90% had extraoral manifestations (95% CI 52.41 to 68.78). The disease was most commonly inherited in an autosomal dominant manner (88.41%, 95% CI 78.5 to 94.26), and about one-third of the patients had syndromic HGF (33.85%, 95% CI 23.50 to 46.00). Gingivectomy was performed in the majority of cases (91.15%, 95% CI 84.31 to 95.29), and recurrence was seen in 33.85% (95% CI 23.50 to 46.00).

Conclusion

HGF should be suspected in children with nodularity and gingival fibrosis, teeth abnormalities, or jaw distortion. Family history can help to establish the diagnosis.

Clinical relevance

More cases should focus on longer-term follow-up after gingivectomy as disease recurrence is not uncommon.

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Title: Hereditary gingival fibromatosis in children: a systematic review of the literature
Authors: Eirini Boutiou
Ioannis A. Ziogas
Dimitrios Giannis
Aikaterini-Elisavet Doufexi
Publication date: 01-06-2021
Publisher: Springer Berlin Heidelberg
Keyword: Fibromatosis
Published in: Clinical Oral Investigations / Issue 6/2021
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-020-03682-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Hereditary gingival fibromatosis in children: a systematic review of the literature

Abstract

Objectives

Methods

Results

Conclusion

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Clinical relevance

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