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Critical Care
Published in: Critical Care 1/2010

01-03-2010 | Poster presentation

Fibrinogen in dilutional coagulopathy: a dose study in pigs

Authors: J Martini, S Maisch, W Martini, W Streif, D Fries

Published in: Critical Care | Special Issue 1/2010

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Excerpt

Dilutional coagulopathy following massive bleeding is the result of clotting factor dilution and impaired fibrin polymerization after infusion of colloidal plasma expanders. Although fibrinogen has been clinically used to treat dilutional coagulopathy [1, 2], the effects of fibrinogen dosages on normalizing coagulation function is unclear. This study investigated the effect of six different fibrinogen dosages (range: 37.5 to 600 mg/kg) on ROTEM® parameters and overall blood loss in a pig model for dilutional coagulopathy. …
Literature
1.
Fenger-Eriksen C, et al.: J Thromb Haemost. 2009, 75: 795-802. 10.1111/j.1538-7836.2009.03331.xCrossRef
2.
Mittermayr M, et al.: Anesth Analg. 2007, 105: 905-917. 10.1213/01.ane.0000280481.18570.27CrossRef
Metadata
Title
Fibrinogen in dilutional coagulopathy: a dose study in pigs
Authors
J Martini
S Maisch
W Martini
W Streif
D Fries
Publication date
01-03-2010
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 1/2010
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc8601

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