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BMC Neurology
Published in: BMC Neurology 1/2007

Open Access 01-12-2007 | Research article

Fibrinogen gamma-A chain precursor in CSF: a candidate biomarker for Alzheimer's disease

Authors: Joung Wook Lee, Hong Namkoong, Hyun Kee Kim, Sanghee Kim, Dong Whi Hwang, Hae Ri Na, Seon-Ah Ha, Jae-Ryong Kim, Jin Woo Kim

Published in: BMC Neurology | Issue 1/2007

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Abstract

Background

Cerebrospinal fluid (CSF) may be valuable for exploring protein markers for the diagnosis of Alzheimer's disease (AD). The prospect of early detection and treatment, to slow progression, holds hope for aging populations with increased average lifespan. The aim of the present study was to investigate candidate CSF biological markers in patients with mild cognitive impairment (MCI) and AD and compare them with age-matched normal control subjects.

Methods

We applied proteomics approaches to analyze CSF samples derived from 27 patients with AD, 3 subjects with MCI and 30 controls. The AD group was subdivided into three groups by clinical severity according to clinical dementia rating (CDR), a well known clinical scale for dementia.

Results

We demonstrated an elevated level of fibrinogen gamma-A chain precursor protein in CSF from patients with mild cognitive impairment and AD compared to the age-matched normal subjects. Moreover, its expression was more prominent in the AD group than in the MCI and correlated with disease severity and progression. In contrast, fibrinogen gamma-A chain precursor protein was detected very low in the age-matched normal group.

Conclusion

These findings suggest that the CSF level of fibrinogen gamma-A chain precursor may be a candidate biomarker for AD.
Appendix
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Metadata
Title
Fibrinogen gamma-A chain precursor in CSF: a candidate biomarker for Alzheimer's disease
Authors
Joung Wook Lee
Hong Namkoong
Hyun Kee Kim
Sanghee Kim
Dong Whi Hwang
Hae Ri Na
Seon-Ah Ha
Jae-Ryong Kim
Jin Woo Kim
Publication date
01-12-2007
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2007
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/1471-2377-7-14

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